Introducing the Quantum Research Kernels: Lessons from Classical Parallel Computing

Quantum computing represents a paradigm shift for computation requiring an entirely new computer architecture. However, there is much that can be learned from traditional classical computer engineering. In this paper, we describe the Parallel Research Kernels (PRK), a tool that was very useful for designing classical parallel computing systems. The PRK are simple kernels written to expose bottlenecks that limit classical parallel computing performance. We hypothesize that an analogous tool for quantum computing, Quantum Research Kernels (QRK), may similarly aid the co-design of software and hardware for quantum computing systems, and we give a few examples of representative QRKs.Comment: 2 page

Ischemic Postconditioning during Cardiopulmonary Resuscitation Improves Acute Outcomes in a Porcine Model of Prolonged Cardiac Arrest

University of Minnesota Ph.D. dissertation. August 2017. Major: Integrative Biology and Physiology. Advisor: Demetri Yannopoulos. 1 computer file (PDF); ix, 133 pages.Cardiac arrest (CA) is the cessation of blood flow due to electrical or mechanical failure of the heart resulting in whole-body ischemia. Out-of-hospital CA (OHCA) is a medical emergency occurring in approximately 350,000 people in the United States each year with a survival rate of 5-15%. Mechanical improvements to cardiopulmonary resuscitation (CPR) as well as organizing a systems-based approach to resuscitation have resulted in only modest improvements in survival. Novel resuscitation strategies are necessary to improve survival following OHCA. Two phases of injury are associated with prolonged ischemia: an initial injury during untreated ischemia, followed by paradoxical damage that occurs upon reperfusion. During CA, ischemic injury occurs prior to resuscitation efforts, whereas reperfusion injury begins when CPR is initiated. The extent and development of reperfusion injury during resuscitation following OHCA is poorly characterized. Postconditioning, a suite of strategies applied after a lethal ischemia to mitigate reperfusion injury, can attenuate infarct size and organ dysfunction in the heart and brain when applied early during reperfusion. Following a CA, reperfusion is initiated with CPR. Thus, postconditioning strategies are predicted to have the greatest efficacy when applied during CPR for the treatment of CA. Ischemic postconditioning (IPC), a technique of non-lethal pauses in blood flow during early reperfusion, has demonstrated protection of vital organs after focal ischemia. The ability to protect multiple organs makes IPC an appealing therapeutic for the whole-body ischemia of CA. Further, IPC is ideal for CA because controlled pauses in reperfusion can be accomplished simply by interrupting continuous chest compressions. The central hypothesis of this work is that IPC implemented at the initiation of CPR can improve cardiac and neurologic recovery after prolonged CA. This work details experiments investigating the feasibility and efficacy of implementing a simple IPC strategy at the onset of CPR to mitigate organ and mitochondrial dysfunction following prolonged ventricular fibrillation (VF) CA. In a porcine model, IPC drastically improved cardiac function and neurologically favorable survival after 15 minutes of VF CA. IPC also improved hemodynamics during CPR and increased cardiac mitochondrial function in the acute phase of resuscitation. A combination of IPC with other postconditioning strategies promoted cardiac and neurologic recovery after 17 minutes of untreated VF CA, a duration not previously compatible with positive outcomes in a porcine model. The mechanisms that mediate cardiac and neurologic protection remain undetermined, though evidence suggests increased coronary perfusion pressure during resuscitation is necessary and sufficient to restore acute cardiac mitochondrial function after prolonged VF CA. These experiments highlight the impact of early CPR interventions on long-term outcomes, and emphasize the importance of continued innovation in resuscitation therapies. Every incremental improvement to resuscitation care has the potential to save thousands of lives

Period and chemical evolution of SC stars

The SC and CS stars are thermal-pulsing AGB stars with C/O ratio close to unity. Within this small group, the Mira variable BH Cru recently evolved from spectral type SC (showing ZrO bands) to CS (showing weak C2). Wavelet analysis shows that the spectral evolution was accompanied by a dramatic period increase, from 420 to 540 days, indicating an expanding radius. The pulsation amplitude also increased. Old photographic plates are used to establish that the period before 1940 was around 490 days. Chemical models indicate that the spectral changes were caused by a decrease in stellar temperature, related to the increasing radius. There is no evidence for a change in C/O ratio. The evolution in BH Cru is unlikely to be related to an on-going thermal pulse. Periods of the other SC and CS stars, including nine new periods, are determined. A second SC star, LX Cyg, also shows evidence for a large increase in period, and one further star shows a period inconsistent with a previous determination. Mira periods may be intrinsically unstable for C/O ~ 1; possibly because of a feedback between the molecular opacities, pulsation amplitude, and period. LRS spectra of 6 SC stars suggest a feature at wavelength > 15 micron, which resembles one recently attributed to the iron-sulfide troilite. Chemical models predict a large abundance of FeS in SC stars, in agreement with the proposed association.Comment: 14 pages, 20 figures. MNRAS, 2004, accepted for publication. Janet Mattei, one of the authors, died on 22 March, 2004. This paper is dedicated to her memor

A New Era in Extragalactic Background Light Measurements: The Cosmic History of Accretion, Nucleosynthesis and Reionization

(Brief Summary) What is the total radiative content of the Universe since the epoch of recombination? The extragalactic background light (EBL) spectrum captures the redshifted energy released from the first stellar objects, protogalaxies, and galaxies throughout cosmic history. Yet, we have not determined the brightness of the extragalactic sky from UV/optical to far-infrared wavelengths with sufficient accuracy to establish the radiative content of the Universe to better than an order of magnitude. Among many science topics, an accurate measurement of the EBL spectrum from optical to far-IR wavelengths, will address: What is the total energy released by stellar nucleosynthesis over cosmic history? Was significant energy released by non-stellar processes? Is there a diffuse component to the EBL anywhere from optical to sub-millimeter? When did first stars appear and how luminous was the reionization epoch? Absolute optical to mid-IR EBL spectrum to an astrophysically interesting accuracy can be established by wide field imagingat a distance of 5 AU or above the ecliptic plane where the zodiacal foreground is reduced by more than two orders of magnitude.Comment: 7 pages; Science White Paper for the US Astro 2010-2020 Decadal Survey. If interested in further community-wide efforts on this topic please contact the first autho

Ketone Ester Treatment Improves Cardiac Function and Reduces Pathologic Remodeling in Preclinical Models of Heart Failure

BACKGROUND: Accumulating evidence suggests that the failing heart reprograms fuel metabolism toward increased utilization of ketone bodies and that increasing cardiac ketone delivery ameliorates cardiac dysfunction. As an initial step toward development of ketone therapies, we investigated the effect of chronic oral ketone ester (KE) supplementation as a prevention or treatment strategy in rodent heart failure models. METHODS: Two independent rodent heart failure models were used for the studies: transverse aortic constriction/myocardial infarction (MI) in mice and post-MI remodeling in rats. Seventy-five mice underwent a prevention treatment strategy with a KE comprised of hexanoyl-hexyl-3-hydroxybutyrate KE (KE-1) diet, and 77 rats were treated in either a prevention or treatment regimen using a commercially available β-hydroxybutyrate-(R)-1,3-butanediol monoester (DeltaG; KE-2) diet. RESULTS: The KE-1 diet in mice elevated β-hydroxybutyrate levels during nocturnal feeding, whereas the KE-2 diet in rats induced ketonemia throughout a 24-hour period. The KE-1 diet preventive strategy attenuated development of left ventricular dysfunction and remodeling post-transverse aortic constriction/MI (left ventricular ejection fraction±SD, 36±8 in vehicle versus 45±11 in KE-1; P=0.016). The KE-2 diet therapeutic approach also attenuated left ventricular dysfunction and remodeling post-MI (left ventricular ejection fraction, 41±11 in MI-vehicle versus 61±7 in MI-KE-2; P<0.001). In addition, ventricular weight, cardiomyocyte cross-sectional area, and the expression of ANP (atrial natriuretic peptide) were significantly attenuated in the KE-2-treated MI group. However, treatment with KE-2 did not influence cardiac fibrosis post-MI. The myocardial expression of the ketone transporter and 2 ketolytic enzymes was significantly increased in rats fed KE-2 diet along with normalization of myocardial ATP levels to sham values. CONCLUSIONS: Chronic oral supplementation with KE was effective in both prevention and treatment of heart failure in 2 preclinical animal models. In addition, our results indicate that treatment with KE reprogrammed the expression of genes involved in ketone body utilization and normalized myocardial ATP production following MI, consistent with provision of an auxiliary fuel. These findings provide rationale for the assessment of KEs as a treatment for patients with heart failure

Is abdominal wall contraction important for normal voiding in the female rat?

BACKGROUND: Normal voiding behavior in urethane-anesthetized rats includes contraction of the abdominal wall striated muscle, similar to the visceromotor response (VMR) to noxious bladder distension. Normal rat voiding requires pulsatile release of urine from a pressurized bladder. The abdominal wall contraction accompanying urine flow may provide a necessary pressure increment for normal efficient pulsatile voiding. This study aimed to evaluate the occurrence and necessity of the voiding-associated abdominal wall activity in urethane-anesthetized female rats METHODS: A free-voiding model was designed to allow assessment of abdominal wall activity during voiding resulting from physiologic bladder filling, in the absence of bladder or urethral instrumentation. Physiologic diuresis was promoted by rapid intravascular hydration. Intercontraction interval (ICI), voided volumes and EMG activity of the rectus abdominis were quantified. The contribution of abdominal wall contraction to voiding was eliminated in a second group of rats by injecting botulinum-A (BTX, 5 U) into each rectus abdominis to induce local paralysis. Uroflow parameters were compared between intact free-voiding and BTX-prepared animals. RESULTS: Abdominal wall response is present in free voiding. BTX preparation eliminated the voiding-associated EMG activity. Average per-void volume decreased from 1.8 ml to 1.1 ml (p < 0.05), and reduced average flow from 0.17 ml/sec to 0.11 ml/sec (p < 0.05). Intercontraction interval (ICI) was not changed by BTX pretreatment. CONCLUSION: The voiding-associated abdominal wall response is a necessary component of normal voiding in urethane anesthetized female rats. As the proximal urethra may be the origin of the afferent signaling which results in the abdominal wall response, the importance of the bladder pressure increment due to this response may be in maintaining a normal duration intermittent pulsatile high frequency oscillatory (IPHFO)/flow phase and thus efficient voiding. We propose the term Voiding-associated Abdominal Response (VAR) for the physiologic voiding-associated EMG/abdominal wall response, to distinguish it from the visceromotor response (VMR) to noxious bladder distension

Post-conditioning to improve cardiopulmonary resuscitation

International audienc