Endoscopic Biliary Drainage Using Guidewire Cannulation in a Case with Severe Duodenal Stenosis Caused by Duodenal Undifferentiated Carcinoma

We present a case of duodenal carcinoma, 12 cm in size, with severe stenosis at the second portion of the duodenum. When the patient developed obstructive jaundice, it was impossible to perform endoscopic biliary drainage by standard cannulation due to the stenosis, but was succeeded by wire-guided cannulation using papillotome. Histology of the tumor showed undifferentiated carcinoma without differentiation to any specific cell type. Systemic chemotherapy was started with 5-FU, leucovorin and oxaliplatin. Biliary stent worked well until the patient succumbed three months after. Herein we demonstrate the new advantage of wire-guided cannulation in case of duodenal stenosis

Autoimmune Pancreatitis Accompanied by Cholecystitis, Periaortitis and Pseudotumors of the Liver

A variety of extrapancreatic lesions have been associated with autoimmune pancreatitis (AIP), and these lesions can be difficult to diagnose. We report a patient referred to Shizuoka Cancer Center with the diagnosis of a possible biliary carcinoma with liver metastasis who was shown to have AIP accompanied by pseudotumors of liver. Clinical imaging revealed diffuse enlargement of the head of the pancreas with irregular narrowing of the main pancreatic duct and inferior common bile duct, multiple liver masses, mediastinal lymphadenopathy, and thickening of the wall of the gallbladder and abdominal aorta. Cytology and biopsy from the pancreaticobiliary tract was negative for malignancy. Serum carcinoembryonic antigen (CEA) and carbohydrate antigen (CA19-9) levels were in the normal range, but soluble interleukin 2 receptor (sIL2R), IgG4 and antinuclear antibody were abnormally high (sIL2R: 2,550 U/ml; IgG4: 764 mg/dl). Corticosteroid therapy was effective and these abnormal findings all improved. This case demonstrates the clinical importance of AIP accompanied by other systemic disorders in the differential diagnosis of patients with a pancreatic mass lesion

ラット灌流肝のブロモクリプチン消失過程に対するチトクロームP450 3A代謝系の寄与およびフリーラジカル産生系のおよぼす影響の薬物動態学的評価

京都大学0048新制・課程博士博士(医学)甲第6802号医博第1902号新制||医||666(附属図書館)15874UT51-97-H186京都大学大学院医学研究科社会医学系専攻(主査)教授 中尾 一和, 教授 清野 裕, 教授 福井 有公学位規則第4条第1項該当Doctor of Medical ScienceKyoto UniversityDA

The current status of Open Access in biomedical field: the comparison of countries relating to the impact of national policies

The purpose of the article is to show the current status of Open Access (OA) in biomedical field, and compare some countries such as the U.S., the U.K. and Japan in terms of the OA situation. There are controversies about the definition of OA. After examining the requirements about OA, we recognized OA as the situation in which researchers could read the full text of articles in unrestricted way. In order to investigate the current situation of OA, 4,756 articles were sampled randomly from articles published between January and September in 2005 and indexed in PubMed. The main results are as follows: 1) The rate of OA articles was 25%, and 75% of all the articles were available online including electronic subscription journal articles. 2) The means of OA was classified into five types. Among them, the rate of OA articles by “OA and Hybrid OA journals” was overwhelming (more than 70%), and that of PMC was 26.2%. The rates of OA articles by “institutional repositories” and “authors’ personal sites” were considerably low (6.0% and 4.9% respectively). 3) When comparing the rates of OA articles by countries, Belgium ranked the first with 41.7%. The five countries indicated more than 30% in OA articles: Canada and India (38.7%), Brazil (36.4%), Australia (30.8%), and the U.S. (30.7%). Each country was different in the means of OA. 4) We explored the rates of OA for two groups; one group consists of articles published in journals with an impact factor (IF), and the other consists of articles published in journals without IF. The rate of OA for the group of articles in journals with IF is 20.6%, and that of articles in journals without IF is 30.8%

Current status of open access in biomedical field-the comparison of countries related to the impact of national policies

The purpose of the article is to show the current status of Open Access (OA) in biomedical field, and compare some countries such as the U.S., the U.K. and Japan in terms of the OA situation. There are controversies about the definition of OA. After examining the requirements about OA, we recognized OA as the situation in which researchers could read the full text of articles in unrestricted way. In order to investigate the current situation of OA, 4,756 articles were sampled randomly from articles published between January and September in 2005 and indexed in PubMed. The main results are as follows: 1) The rate of OA articles was 25%, and 75% of all the articles were available online including electronic subscription journal articles. 2) The means of OA was classified into five types. Among them, the rate of OA articles by “OA and Hybrid OA journals” was overwhelming (more than 70%), and that of PMC was 26.2%. The rates of OA articles by “institutional repositories” and “authors’ personal sites” were considerably low (6.0% and 4.9% respectively). 3) When comparing the rates of OA articles by countries, Belgium ranked the first with 41.7%. The five countries indicated more than 30% in OA articles: Canada and India (38.7%), Brazil (36.4%), Australia (30.8%), and the U.S. (30.7%). Each country was different in the means of OA. 4) We explored the rates of OA for two groups; one group consists of articles published in journals with IF, and the other consists of articles published in journals without IF. The rate of OA for the group of articles in journals with IF is 20.6%, and that of articles in journals without IF is 30.8%

Remarkable growth of open access in the biomedical field: analysis of PubMed articles from 2006 to 2010.

INTRODUCTION: This study clarifies the trends observed in open access (OA) in the biomedical field between 2006 and 2010, and explores the possible explanations for the differences in OA rates revealed in recent surveys. METHODS: The study consists of a main survey and two supplementary surveys. In the main survey, a manual Google search was performed to investigate whether full-text versions of articles from PubMed were freely available. Target samples were articles published in 2005, 2007, and 2009; the searches were performed a year after publication in 2006, 2008, and 2010, respectively. Using the search results, we classified the OA provision methods into seven categories. The supplementary surveys calculated the OA rate using two search functions on PubMed: "LinkOut" and "Limits." RESULTS: The main survey concluded that the OA rate increased significantly between 2006 and 2010: the OA rate in 2010 (50.2%) was twice that in 2006 (26.3%). Furthermore, majority of OA articles were available from OA journal (OAJ) websites, indicating that OAJs have consistently been a significant contributor to OA throughout the period. OA availability through the PubMed Central (PMC) repository also increased significantly. OA rates obtained from two supplementary surveys were lower than those found in the main survey. "LinkOut" could find only 40% of OA articles in the main survey. DISCUSSION: OA articles in the biomedical field have more than a 50% share. OA has been achieved through OAJs. The reason why the OA rates in our surveys are different from those in recent surveys seems to be the difference in sampling methods and verification procedures

Number of sample articles for each survey.

<p>Number of sample articles for each survey.</p