High energy nucleon-nucleon and pion-nucleon collision model for nuclear cascade Final technical report

Development of model for description of nucleon-nucleon and pion-nucleon collisions at high energy and Monte Carlo description of Nucleor Cascad

2005 Nutrient and Sediment Monitoring Report Ballard Creek Near Arkansas/Oklahoma Line

The Illinois River Basin has experienced water quality impairment from non-point source pollution for many years. This fact was well documented in the State of Arkansas\u27 Water Quality Assessment report, the Soil Conservation Service River Basin Study, and several University of Arkansas studies. Thirty-seven sub-watersheds have been identified by the SCS in the Arkansas portion of the Illinois River basin. In the Arkansas portion of the Basin, the Illinois River, Evansville Creek, Baron Fork, Cincinnati Creek, Muddy Fork, Moores Creek, Clear Creek, Osage Creek and Flint Creek were all classified as not supporting their designated use as primary contact recreation streams. The identified causes of the impairment were: sediment, bacteria and nutrients. In 1997, the University of Arkansas completed a project that estimated the phosphorus loading from each of the thirty-seven sub-watersheds. This project also prioritized watersheds for implementation work based on phosphorus loads, nitrogen loads and total suspended solids loads per unit area. The thirty-seven sub-watersheds were grouped into Low (16), Medium (10) and High (11) categories based on phosphorus loadings. The selection of a sub-watershed for targeted intensive voluntary BMP implementation was based on the following criteria: a) the sub-watershed had to be above the current median value for phosphorus loading, b) there would be no sewage treatment plant in the sub-watershed, and c) land user interest. The Upper Ballard Creek watershed met all these requirements. The watershed covers 6700 hectares. The creek is listed in the High category with a unit area loading of 1.75 kg. per hectare per year. The median value for the thirty-seven watersheds was 0.73 kg. per hectare per year

Smashing New Results on Aspectual Framing: How People Talk About Car Accidents

How do people describe events they have witnessed? What role does linguistic aspect play in this process? To provide answers to these questions, we conducted an experiment on aspectual framing. In our task, people were asked to view videotaped vehicular accidents and to describe what happened (perfective framing) or what was happening (imperfective framing). Our analyses of speech and gesture in retellings show that the form of aspect used in the question differentially influenced the way people conceptualized and described actions. Questions framed with imperfective aspect resulted in more motion verbs (e.g., driving), more reckless language (e.g., speeding), and more iconic gestures (e.g., path gesture away from the body to show travel direction) than did questions framed with perfective aspect. Our research contributes novel insights on aspect and the construal of events, and on the semantic potency of aspect in leading questions. The findings are consistent with core assumptions in cognitive linguistics, including the proposal that linguistic meaning, including grammatical meaning, is dynamic and grounded in perceptual and cognitive experience

U-drawing of Fortiform 1050 third generation steels. Numerical and experimental results

Elasto–plastic behavior of the third generation Fortiform 1050 steel has been analysed using cyclic tension–compression tests. At the same time, the pseudo elastic modulus evolution with plastic strain was analysed using cyclic loading and unloading tests. From the experiments, it was found that the cyclic behavior of the steel is strongly kinematic and elastic modulus decrease with plastic strain is relevant for numerical modelling. In order to numerically analyse a U-Drawing process, strip drawing tests have been carried out at different contact pressures and Filzek model has been used to fit the experimental data and implement a pressure dependent friction law in Autoform software. Finally, numerical predictions of springback have been compared with the experimentally ones obtained using a sensorized UDrawing tooling. Different material and contact models have been examined and most influencing parameters have been identified to model the forming of these new steels

Designing Shared Decision-Making Interventions for Dissemination and Sustainment: Can Implementation Science Help Translate Shared Decision Making Into Routine Practice

Shared decision making (SDM) is not widely practiced in routine care due to a variety of organizational, provider, patient, and contextual factors. This article explores how implementation science-which encourages attention to the multilevel contextual factors that influence the adoption, implementation, and sustainment of health care practices-can provide useful insights for increasing SDM use in routine practice. We engaged with stakeholders representing different organizations and geographic locations over three phases: 1) multidisciplinary workgroup meeting comprising researchers and clinicians (n = 11); 2) survey among a purposive sample of 47 patient advocates, clinicians, health care system leaders, funders, policymakers, and researchers; and 3) working session among diverse stakeholders (n = 30). The workgroup meeting identified priorities for action and research, which included targeting multiple audiences and levels, shifting culture toward valuing and supporting SDM, and considering contextual factors influencing SDM implementation. Survey respondents provided recommendations for increasing adoption, implementation, and maintenance of SDM in practice including providing tools to support SDM, obtaining stakeholders\u27 involvement, and raising awareness of the importance of SDM. Stakeholders in the working session provided recommendations on the design of a guide for implementation of SDM in clinical settings, strategies to disseminate educational curricula on SDM, and strategies to influence policies to increase SDM use. These specific recommendations serve as a call to action to pursuing specific promising strategies aimed at increasing SDM use in practice and enhance understanding of the perspectives of diverse stakeholders at multiple levels from an implementation science perspective that appear fruitful for further study and application

Perspectives of scientists on disseminating research findings to non-research audiences

BACKGROUND: Little is known about practices used to disseminate findings to non-research, practitioner audiences. This study describes the perspectives, experience and activities of dissemination & implementation (D&I) scientists around disseminating their research findings. METHODS: The study explored D&I scientists\u27 experiences and recommendations for assessment of dissemination activities to non-research audiences. Existing list serves were used to recruit scientists. Respondents were asked three open-ended questions on an Internet survey about dissemination activities, recommendations for changing evaluation systems and suggestions to improve their own dissemination of their work. RESULTS: Surveys were completed by 159 scientists reporting some training, funding and/or publication history in D&I. Three themes emerged across each of the three open-ended questions. Question 1 on evaluation generated the themes of: 1a) promotional review; 1b) funding requirements and 1c) lack of acknowledgement of dissemination activities. Question 2 on recommended changes generated the themes of: 2a) dissemination as a requirement of the academic promotion process; 2b) requirement of dissemination plan and 2c) dissemination metrics. Question 3 on personal changes to improve dissemination generated the themes of: 3a) allocation of resources for dissemination activities; 3b) emerging dissemination channels and 3c) identify and address issues of priority for stakeholders. CONCLUSIONS: Our findings revealed different types of issues D&I scientists encounter when disseminating findings to clinical, public health or policy audiences and their suggestions to improve the process. Future research should consider key requirements which determine academic promotion and grant funding as an opportunity to expand dissemination efforts

Investigation of translocation, DNA unwinding, and protein displacement by NS3h, the helicase domain from the Hepatitis C virus helicase

Helicases are motor proteins that are involved in DNA and RNA metabolism, replication, recombination, transcription and repair. The motors are powered by ATP binding and hydrolysis. Hepatitis C virus encodes a helicase called non-structural protein (NS3). NS3 possesses protease and helicase activities on its N-terminal and C-terminal domains respectively. The helicase domain of NS3 protein is referred as NS3h. In vitro, NS3h catalyzes RNA and DNA unwinding in a 3’ to -5’ direction. The directionality for unwinding is thought to arise in part from the enzyme's ability to translocate along DNA, but translocation has not been shown explicitly. We examined the DNA translocase activity of NS3h by using single-stranded oligonucleotide substrates containing a fluorescent probe on the 5’ end. NS3h can bind to the ssDNA and in the presence of ATP, move towards the 5’-end. When the enzyme encounters the fluorescent probe, a fluorescence change is observed that allows translocation to be characterized. Under conditions that favor binding of one NS3h per DNA substrate (100 nM NS3h, 200 nM oligonucleotide) we find that NS3h translocates on ssDNA at a rate of 46 ± 5 nt s−1 and that it can move for 230 ± 60 nt before dissociating from the DNA. The translocase activity of some helicases is responsible for displacing proteins that are bound to DNA. We studied protein displacement by using a ssDNA oligonucleotide covalently linked to biotin on the 5’-end. Upon addition of streptavidin, a ‘protein-block’ was placed in the pathway of the helicase. Interestingly, NS3h was unable to displace streptavidin from the end of the oligonucleotide, despite its ability to translocate along the DNA. The DNA unwinding activity of NS3h was examined using a 22 bp duplex DNA substrate under conditions that were identical to those used to study translocation. NS3h exhibited little or no DNA unwinding under single cycle conditions, supporting the conclusion that NS3h is a relatively poor helicase in its monomeric form, as has been reported. In summary, NS3h translocates on ssDNA as a monomer, but the translocase activity does not correspond to comparable DNA unwinding activity or protein-displacement activity under identical conditions