Скрининг сердечно-сосудистой системы футбольных арбитров перед игрой: клинические результаты и опыт

Arbitrii de fotbal sunt supuși unui efort fizic analogic sportivilor profesioniști în timpul meciului, totodată aceştia sunt implicați intens în cantonamentul săptămânal înainte de meci. Prin urmare, arbitrii de fotbal, asemeni sportivilor, riscă să facă moarte subită cardiacă (MSC), cauzată de insuficiența cardiacă de bază.Футбольные арбитры испытывают аналогичные физические нагрузки как и профессиональные игроки во время матча, а также они часто подвергаются долгосрочной интенсивной недельной подготовке перед матчем. Следовательно, судьи одинаково подвержены риску внезапной сердечной смерти (ВСС) из-за основных сердечных расстройств

Strut coverage and vessel wall response to zotarolimus-eluting and bare-metal stents implanted in patients with ST-segment elevation myocardial infarction: The OCTAMI (Optical Coherence Tomography in Acute Myocardial Infarction) study

Objectives Using optical coherence tomography, we assessed the proportion of uncovered struts at 6-month follow-up in zotarolimus-eluting stents (ZES), specifically Endeavor (Medtronic CardioVascular, Santa Rosa, California) stents, and identical bare-metal stents (BMS) implanted in patients with ST-segment elevation myocardial infarction (STEMI). Background Sirolimus-and paclitaxel-eluting stents implanted in STEMI have been associated with delayed healing and incomplete strut coverage. ZES are associated with a more complete and uniform strut coverage in stable patients, but whether this holds true also after STEMI is unknown. Methods Forty-four patients with STEMI who underwent primary PCI were randomized to ZES or BMS (3:1 randomization). Angiographic, intravascular ultrasound, and optical coherence tomography follow-up was conducted at 6 months and clinical follow-up at 1 year. All images were analyzed by an independent core laboratory that was blind to stent assignments. Results There were no differences between ZES and BMS in percentage of uncovered struts (median: 0.00% [interquartile range (IQR): 0.00% to 1.78%] vs. 1.98% [IQR: 0.21% to 7.33%], p = 0.13), maximum length of uncovered segments (0.00 [IQR: 0.00 to 1.19] mm vs. 1.38 [IQR: 0.65 to 3.30] mm, p = 0.10), percentage of malapposed struts (0.00% [IQR: 0.00% to 0.23%] vs. 0.15% [IQR: 0.00% to 5.81%], p = 0.16), and maximum length of malapposed segments (0.00 [IQR: 0.00 to 0.67] mm vs. 0.33 [IQR: 0.00 to 2.55] mm, p = 0.20). Neointimal response was similar between ZES and BMS (332 [IQR: 240 to 429] =m vs. 186 [IQR: 136 to 348] =m, p = 0.99) and evenly distributed. No late acquired malapposition was observed in both groups. There were no deaths, myocardial infarction, or stent thromboses at 1 year. Conclusions This optical coherence tomography study found no difference in strut coverage and similar vessel response to ZES, when compared with identical BMS, implanted during primary percutaneous coronary intervention in STEMI patients. (Six-Month Coverage and Vessel Wall Response of the Zotarolimus Drug-Eluting Stent Implanted in AMI Assessed by Optical Coherence Tomography [OCTAMI]; NCT00704561) © 2010 BY THE AMERICAN COLLEGE OF CARDIOLOGY FOUNDATION

Examination of the In Vivo Mechanisms of Late Drug-Eluting Stent Thrombosis Findings From Optical Coherence Tomography and Intravascular Ultrasound Imaging

Objectives This study investigated the role of uncovered stent struts on late stent thrombosis (LST) after drug-eluting stent (DES) implantation with optical coherence tomography (OCT). Background Autopsy studies have identified delayed healing and lack of endothelialization of DES struts as the hallmarks of LST. DES strut coverage has not previously been examined in vivo in patients with LST. Methods We studied 54 patients, including 18 with DES LST (median 615 days after implant) undergoing emergent percutaneous coronary interventions and 36 matched DES control subjects undergoing routine repeat OCT and intravascular ultrasound (IVUS) who did not experience LST for >= 3 years. Thrombus aspiration was performed during emergent percutaneous coronary intervention before OCT and IVUS assessment. Results By OCT, patients with LST-compared with control subjects had a higher percentage of uncovered (median [interquartile range]) (12.27 [5.50 to 23.33] vs. 4.14 [3.00 to 6.22], p < 0.001) and malapposed (4.60 [1.85 to 7.19] vs. 1.81 [0.00 to 2.99], p < 0.001) struts. The mean neointimal thickness was similar in the 2 groups (0.23 +/- 0.17 mm vs. 0.17 +/- 0.09 mm, p = 0.28). By IVUS, stent expansion was comparable in the 2 groups, although positive remodeling was increased in patients with LST (mean vessel cross-section area 19.4 +/- 5.8 mm(2) vs. 15.1 +/- 4.6 mm(2), p = 0.003). Thrombus aspiration demonstrated neutrophils and eosinophils in most cases. By multivariable analysis, the length of segment with uncovered stent struts by OCT and the remodeling index by IVUS were independent predictors of LST. Conclusions In this in vivo case-controlled study, the presence of uncovered stent struts as assessed by OCT and positive vessel remodeling as imaged by IVUS were associated with LST after DES. (J Am Coll Cardiol Intv 2012;5:12-20) (C) 2012 by the American College of Cardiology Foundatio

ნიადაგის რადონის და ჰაერის ელექტროგამტარობის კავშირი მიწისძვრებთან

განხილულია საქართველოს პირობებში მიწისძვრების ეფექტი ნიადაგის რადონის შემცველობის და ჰაერის ელექტროგამტარობის ცვალებადობაშ

Serial Assessment of Coronary Artery Response to Paclitaxel-Eluting Stents Using Optical Coherence Tomography

Background-The paucity of longitudinal, serial high-resolution imaging studies has limited our understanding of in vivo arterial response to drug-eluting stents. We sought to investigate the human coronary response to paclitaxel-eluting stent implantation, using serial optical coherence tomography assessments. Methods and Results-Thirty patients with at least 2 significant coronary lesions in different vessels were treated with a paclitaxel-eluting stent. The most severe stenosis (lesion A) was treated at the initial procedure, and the second target vessel (lesion B) was stented 3 months later. Optical coherence tomography was performed at baseline, 3-, and 9-month follow-up for lesions A and baseline and 6 months for lesions B. Prespecified end points were percent of uncovered and malapposed struts over time. In lesions A, uncovered struts were 3.77 +/- 4.94% and 3.02 +/- 4.35% at 3 versus 9 months (P = NS). Malapposed struts were 3.55 +/- 5.16% at post-procedure, 1.51 +/- 3.52% at 3 months, and 0.60 +/- 1.82% at 9 months (P < 0.05, at 3 versus 9 months). Strut-level neointimal thickness was 0.19 +/- 0.09 mm and 0.20 +/- 0.11 mm (P = NS) over time. Newly acquired malapposition was detected in 10.4% and 3.3% of 2.5-mm segments at 3- and 9-month follow-up. In lesions B, uncovered struts were 2.91 +/- 5.47% at 6-months. Malapposed struts were 4.94 +/- 6.70% post-procedure and 1.01 +/- 3.11% at 6 months (P<0.01), with 0.19 +/- 0.09-mm neointimal thickness at follow-up. Conclusions-Optical coherence tomography imaging suggested the first 3 months to be the period with most biological activity after paclitaxel-eluting stent implantation, when the proliferative reaction mainly occurs and malapposition resolves. A less active, yet continuous, dynamic arterial response, with resolution and development of malapposition, occurs through 9 months post-treatment

დუშეთის ობსერვატორიაზე დაფიქსირებული გეომაგნიტური ველის ვარიაციები (იანვარი - ივნისი 2013)

Georgia is a part of the far-extending seismically active region, which includes the whole Caucasus, Northern parts of Turkey, Bulgaria, etc. These territories witnessed several intense destructive earthquakes. Thus carrying out possible short-term prognosis of earthquakes is very important for the country. The statistic evidence for reliability of the geomagnetic precursor is based on the distributions of the time difference between occurred and predicted earthquakes for the period January-June of 2013 for Dusheti region. Before strong earthquake magnetic precursors denoted by many authors, but must to say, that more of them don’t satisfy stern criterions. For estimation of the geomagnetic variations as reliable precursor it was discovered the specific time analysis for digital definition of Geomagnetic Quake and proposed way for interval defined from the extremum of local tide variations. The method of earthquake’s predictions are based on the correlation between geomagnetic quakes and the incoming minimum (or maximum) of tidal gravitational potential. The geomagnetic quake is defined as a jump of day mean value of geomagnetic field one minute standard deviation measured at least 2.5 times per second. The probability time window for the incoming earthquake or earthquakes is approximately ± 1 day for the tidal minimum and for the maximum- ± 2 days

Optical Coherence Tomography Assessment of In Vivo Vascular Response After Implantation of Overlapping Bare-Metal and Drug-Eluting Stents

Objectives We designed a randomized trial exploiting optical coherence tomography (OCT) to assess coverage and apposition of overlapping bare-metal stents (BMS) and drug-eluting stents (DES) in human coronary arteries. Background Overlapping DES impair healing in animals. Optical coherence tomography allows accurate in vivo assessment of stent strut coverage and apposition. Methods Seventy-seven patients with long coronary stenoses were randomized to overlapping sirolimus-eluting stents (SES), paclitaxel-eluting stents (PES), zotarolimus-eluting stents (ZES), or BMS. The primary goal of the study was to determine the rate of uncovered/malapposed strut; in overlap versus nonoverlap segments, according to stent type, at 6-month follow-up with OCT. Results A total of 53,047 struts were analyzed. The rate of uncovered/malapposed struts was 1.5 +/- 3.4% and 0.6 +/- 2.7% in overlap versus nonoverlap BMS (p = NS), respectively, and 4.3 +/- 11% and 3.6 +/- 8% in overlap versus nonoverlap DES (p = NS), respectively. There were no differences in the rates of uncovered/malapposed struts between overlapping BMS and DES, likely due to law frequency of uncovered/malapposed struts in ZES (0.1 +/- 0.4%), which offset the higher rates observed in SES (6.7 +/- 9.6%) and PES (6.7 +/- 16.5%, p < 0.05). Overlap segments showed greater neointimal volume obstruction versus nonoverlap segments in all DES (p < 0.05 for all DES types). Strut-level neointimal thickness at overlap and nonoverlap segments were lowest in SES (0.16 +/- 0.1 mm and 0.12 +/- 0.1 mm, respectively) compared with PES (0.27 +/- 0.1 mm and 0.20 +/- 0.1 mm, respectively), ZES (0.40 +/- 0.16 mm and 0.33 +/- 0.13 mm, respectively), and BMS (0.55 +/- 0.31 mm and 0.53 +/- 0.25 mm, respectively, p < 0.05). Conclusions As assessed by OCT the impact of DES on vascular healing was similar at overlapping and nonoverlapping sites. However, strut malapposition, coverage pattern, and neointimal hyperplasia differ significantly according to DES type. (Optical Coherence Tomography for Drug Eluting Stent Safety [ODESSA]; NCT00693030) (J Am Coll Cardiol Intv 2010;3:531-9) (C) 2010 by the American College of Cardiology Foundatio

Study of Stress Variation in the Lithosphere by Multidisciplinary Monitoring

მიწისძვრის წინამორბედების გამოვლინება წარმოადგენს გლობალურ ამოცანას. სტატიაში განხილულია მიწისძვრის მომზადების პროცესში გამოვლენილი ანომალიები. ამ მიზნით დამუშავებულ იქნა ჰიდროდინამიური მომიტორინგის ქსელიდან მიღებული წყლის დონისა და ატმოსფერული წნევის მონაცემები, ასევე დუშეთის გეომაგნიტური ობსერვატორიის მონაცემები. შედეგად, გამოვლინდა მიწისძვრების წინამორბედი ანომალიები და დადასტურდა შემუშავებული დამუშავების მეთოდის მაღალი მგრძნობელობა გეოდინამიკური პროცესების მიმართ.Determination of earthquake precursors is a task of global importance. The article deals about detected anomalies during preparation of average grade earthquake. For this purpose was developed data of the water level and atmospheric pressure from the Hydrodynamic monitoring network, as well as data from Dusheti geomagnetic observatory. Has fixed the hidrogeodeformation field variation caused by the earthquake preparation process and reflection of the critical stress in the water level and abnormal variations of the magnetic field. As a result, have been identified preliminary anomalies and has been confirmed high sensitivity to the geodynamic processes

ბაკურიანის პლატოს საინჟინრო-გეოლოგიური და ჰიდროგეოლოგიური პირობების გამოკვლევა ელექტროძიების ექსპრესმეთოდით IPI2WIN პროგრამული უზრუნველყოფის გამოყენებით

ელექტროძიების ექსპრეს-მეთოდით პროგრამული უზრუნველყოფის IPI2WIN გამოყენებით კვლევის მიზანს წარმოადგენს ბაკურიანის პლატოზე გავრცელებული ნალექების საინჟინრო-გეოლოგიური და ჰიდროგეოლოგიური პირობების დაზუსტება ცენტრალური პროფილის მაგალითზე. IPI2WIN პროგრამული უზრუნველყოფით მიღებული კუთრი ელექტრული წინაღობის ჭრილი კარგ თანხვედრაშია ტრადიციული პალეტური ინტერპრეტაციის შედეგად მიღებულ (I-I’) გეოელექტრულ ჭრილთან

ჰაერის ელექტროგამტარობის ცვალებადობა, როგორც ატმოსფეროს სისუფთავის ფაქტორის

ჩატარებულია ჰაერის ელექტროგამტარობის საშუალო თვიური მნიშვნელობების, როგორც ატმოსფეროს სისუფთავის ფაქტორის, ცვალებადობის გამოკვლევა და შეფასებულია მისი გავლენა ადამიანის ჯანმრთელობაზ