Accelerated wound healing phenotype in Interleukin 12/23 deficient mice

Background: The concept that a strong inflammatory response involving the full complement of cytokines and other mediators is critical for unimpaired healing has been challenged by wound healing studies using transgenic and knockout (KO) mice. The present study explored the effect of abrogation of the p40 subunit, which is shared by the pro-inflammatory cytokines interleukin (IL)-12 and IL-23, on wound closure of excisional oral mucosal wounds

Inclusive nonresonant multilepton probes of new phenomena at s\sqrt{s} = 13 TeV

An inclusive search for nonresonant signatures of beyond the standard model (SM) phenomena in events with three or more charged leptons, including hadronically decaying $\tau$ leptons, is presented. The analysis is based on a data sample corresponding to an integrated luminosity of 138 fb$^{-1}$ of proton-proton collisions at $\sqrt{s}$ = 13 TeV, collected by the CMS experiment at the LHC in 2016-2018. Events are categorized based on the lepton and b-tagged jet multiplicities and various kinematic variables. Three scenarios of physics beyond the SM are probed, and signal-specific boosted decision trees are used for enhancing sensitivity. No significant deviations from the background expectations are observed. Lower limits are set at 95% confidence level on the mass of type-III seesaw heavy fermions in the range 845-1065 GeV for various decay branching fraction combinations to SM leptons. Doublet and singlet vector-like $\tau$ lepton extensions of the SM are excluded for masses below 1045 GeV and in the mass range 125-150 GeV, respectively. Scalar leptoquarks decaying exclusively to a top quark and a lepton are excluded below 1.12-1.42 TeV, depending on the lepton flavor. For the type-III seesaw as well as the vector-like doublet model, these constraints are the most stringent to date. For the vector-like singlet model, these are the first constraints from the LHC experiments. Detailed results are also presented to facilitate alternative theoretical interpretations

Inclusive nonresonant multilepton probes of new phenomena at s\sqrt{s} = 13 TeV

An inclusive search for nonresonant signatures of beyond the standard model (SM) phenomena in events with three or more charged leptons, including hadronically decaying $\tau$ leptons, is presented. The analysis is based on a data sample corresponding to an integrated luminosity of 138 fb$^{-1}$ of proton-proton collisions at $\sqrt{s}$ = 13 TeV, collected by the CMS experiment at the LHC in 2016-2018. Events are categorized based on the lepton and b-tagged jet multiplicities and various kinematic variables. Three scenarios of physics beyond the SM are probed, and signal-specific boosted decision trees are used for enhancing sensitivity. No significant deviations from the background expectations are observed. Lower limits are set at 95% confidence level on the mass of type-III seesaw heavy fermions in the range 845-1065 GeV for various decay branching fraction combinations to SM leptons. Doublet and singlet vector-like $\tau$ lepton extensions of the SM are excluded for masses below 1045 GeV and in the mass range 125-150 GeV, respectively. Scalar leptoquarks decaying exclusively to a top quark and a lepton are excluded below 1.12-1.42 TeV, depending on the lepton flavor. For the type-III seesaw as well as the vector-like doublet model, these constraints are the most stringent to date. For the vector-like singlet model, these are the first constraints from the LHC experiments. Detailed results are also presented to facilitate alternative theoretical interpretations

First evidence for off-shell production of the Higgs boson and measurement of its width

The first evidence for off-shell Higgs production is reported in the final state with two Z bosons decaying into either four charged leptons (muons or electrons), or two charged leptons and two neutrinos, and a measurement of the Higgs boson width is performed. Results are based on data from the CMS experiment at the LHC at a center-of-mass energy of 13 TeV, corresponding to an integrated luminosity of up to 140 fb$^{-1}$. The total rate of off-shell Higgs boson production beyond the Z boson pair production threshold, relative to its standard model expectation, is constrained to the interval [0.0061, 2.0] at 95% confidence level. The scenario with no off-shell production is excluded at 99.97% confidence level (3.6 standard deviations). The width of the Higgs boson is extracted as $\Gamma_{\mathrm{H}}$ = 3.2$_{-1.7}^{+2.4}$ MeV, in agreement with the standard model expectation of 4.1 MeV. The data are also used to set new constraints on anomalous Higgs boson couplings to W and Z boson pairs

Search for resonances decaying to three W bosons in the hadronic final state in proton-proton collisions at s\sqrt{s} = 13 TeV

A search for Kaluza-Klein excited vector boson resonances, W$_\mathrm{KK}$, decaying in cascade to three W bosons via a scalar radion R, W$_\mathrm{KK}$$\to$ WR $\to$ WWW, with two or three massive jets is presented. The search is performed with proton-proton collision data recorded at $\sqrt{s}$ = 13 TeV, collected by the CMS experiment at the CERN LHC, during 2016-2018, corresponding to an integrated luminosity of 138 fb$^{-1}$. Two final states are simultaneously probed, one where the two W bosons produced by the R decay are reconstructed as separate, large-radius, massive jets, and one where they are merged in a single large-radius jet. The data observed are in agreement with the standard model expectations. Limits are set on the product of the W$_\mathrm{KK}$ resonance cross section and branching fraction to three W bosons in an extended warped extra-dimensional model and are the first of their kind at the LHC

Measurement of the inclusive and differential ttˉγ\mathrm{t\bar{t}}\gamma cross sections in the dilepton channel and effective field theory interpretation in proton-proton collisions at s\sqrt{s} =13 TeV

International audienceThe production cross section of a top quark pair in association with a photon is measured in proton-proton collisions in the decay channel with two oppositely charged leptons (e$^{±}$μ$^{∓}$, e$^{+}$e$^{−}$, or μ$^{+}$μ$^{−}$). The measurement is performed using 138 fb$^{−1}$ of proton-proton collision data recorded by the CMS experiment at $\sqrt{s}$ = 13 TeV during the 2016–2018 data-taking period of the CERN LHC. A fiducial phase space is defined such that photons radiated by initial-state particles, top quarks, or any of their decay products are included. An inclusive cross section of 175.2 ± 2.5(stat) ± 6.3(syst) fb is measured in a signal region with at least one jet coming from the hadronization of a bottom quark and exactly one photon with transverse momentum above 20 GeV. Differential cross sections are measured as functions of several kinematic observables of the photon, leptons, and jets, and compared to standard model predictions. The measurements are also interpreted in the standard model effective field theory framework, and limits are found on the relevant Wilson coefficients from these results alone and in combination with a previous CMS measurement of the t$\overline{t}$γ production process using the lepton+jets final state.[graphic not available: see fulltext

Observation of triple J/ψ\psi meson production in proton-proton collisions at s\sqrt{s} = 13 TeV

The first observation of the simultaneous production of three J/$\psi$ mesons in proton-proton (pp) collisions is presented, based on a data sample collected by the CMS experiment at a center-of-mass energy of 13 TeV and corresponding to an integrated luminosity of 133 fb$^{-1}$. The pp $\to$ J/$\psi\,$J/$\psi\,$J/$\psi\,$X process is observed with a significance above five standard deviations in final states with three $\mu^+\mu^-$ pairs. The measured inclusive fiducial cross section of $\sigma$(pp $\to$ J/$\psi\,$J/$\psi\,$J/$\psi\,$X)= 272$^{+141}_{-104}$ (stat) $\pm$ 17 (syst) fb is compared to theoretical expectations for the production of three J/$\psi$ mesons in single- (SPS), double- (DPS), and triple- (TPS) parton scatterings. Assuming factorization of multiple hard-scattering probabilities in terms of SPS cross sections, the measured process is found to be dominated by DPS and TPS contributions, and an effective DPS cross section, related to the transverse distribution of partons in the proton, of $\sigma_\mathrm{eff,DPS}$ = 2.7$^{+1.4}_{-1.0}$ (exp) ${}^{+1.5}_{-1.0}$ (theo) mb is determined

First evidence for off-shell production of the Higgs boson and measurement of its width

The first evidence for off-shell Higgs production is reported in the final state with two Z bosons decaying into either four charged leptons (muons or electrons), or two charged leptons and two neutrinos, and a measurement of the Higgs boson width is performed. Results are based on data from the CMS experiment at the LHC at a center-of-mass energy of 13 TeV, corresponding to an integrated luminosity of up to 140 fb$^{-1}$. The total rate of off-shell Higgs boson production beyond the Z boson pair production threshold, relative to its standard model expectation, is constrained to the interval [0.0061, 2.0] at 95% confidence level. The scenario with no off-shell production is excluded at 99.97% confidence level (3.6 standard deviations). The width of the Higgs boson is extracted as $\Gamma_{\mathrm{H}}$ = 3.2$_{-1.7}^{+2.4}$ MeV, in agreement with the standard model expectation of 4.1 MeV. The data are also used to set new constraints on anomalous Higgs boson couplings to W and Z boson pairs

Measurement of the inclusive and differential ttˉγ\mathrm{t\bar{t}}\gamma cross sections in the dilepton channel and effective field theory interpretation in proton-proton collisions at s\sqrt{s} =13 TeV

The production cross section of a top quark pair in association with a photon is measured in proton-proton collisions in the decay channel with two oppositely charged leptons (e$^\pm\mu^\mp$, e$^+$e$^-$, or $\mu^+\mu^-$). The measurement is performed using 138 fb$^{-1}$ of proton-proton collision data recorded by the CMS experiment at $\sqrt{s}$ =13 TeV during the 2016-2018 data-taking period of the CERN LHC. A fiducial phase space is defined such that photons radiated by initial-state particles, top quarks, or any of their decay products are included. An inclusive cross section of 173.5 $\pm$ 2.5 (stat) $\pm$ 6.3 (syst) fb is measured in a signal region with at least one jet coming from the hadronization of a bottom quark and exactly one photon with transverse momentum above 20 GeV. Differential cross sections are measured as functions of several kinematic observables of the photon, leptons, and jets, and compared to standard model predictions. The measurements are also interpreted in the standard model effective field theory framework, and limits are found on the relevant Wilson coefficients from these results alone and in combination with a previous CMS measurement of the $\mathrm{t\bar{t}}\gamma$ production process using the lepton+jets final state