Association of genome-wide variants with plasma fT4 concentrations.

<p>SNPs that passed QC are plotted on the x-axis according to their chromosomal position against their–log10(<i>p</i>-value). The results were considered genome-wide significant with a <i>p</i><5·10⁻⁸ and a replication threshold was set at <i>p</i><1·10⁻⁶.</p

Effects of genetic variants known to associate with plasma TSH or fT4 concentrations.

<p>Effects from studies in adults compared to the effects of the variants in the cohort from the Danish Childhood Obesity Biobank (TDCOB). Effect sizes are shown in standard deviations (SD) of the rank-normalized TSH or fT4 distribution with 95% confidence intervals. EA is the Effect Allele (from the literature). I² is the measure for heterogeneity between the TDCOB cohort and literature. p(Hetro) is the p-value for the heterogeneity.</p

Lead SNPs from the discovery-, replication- and meta-analyses.

<p>Lead SNPs from the discovery-, replication- and meta-analyses.</p

Association of genome-wide variants with plasma TSH concentrations.

<p>SNPs are plotted on the x-axis according to their chromosomal position against the–log10(<i>p</i>-value). The results were considered genome-wide significant with a <i>p</i><5·10⁻⁸. A threshold for replication was set at <i>p</i><1·10⁻⁶.</p