Variation of IC₅₀ against Dd2 with exposure time.

<p>IC₅₀ after 24 hours in blue; IC50 after 48 hours in red. The IC50 values presented were obtained from two distinct experiments run in duplicate each.</p

2D structures of the isolated compounds.

<p>DES1-Quercitrin, DES2-Afzelin, DES3-Quercetin, DES4-methyl 3,4,5-trihydroxybenzoate ; DES5-Sitosterol 3-O-β-D-glucopyranoside sterol .</p

Cycloartane and Friedelane Triterpenoids from the Leaves of <i>Caloncoba glauca</i> and Their Evaluation for Inhibition of 11β-Hydroxysteroid Dehydrogenases

Five new triterpenoids, caloncobic acids A and B (<b>1</b> and <b>2</b>), caloncobalactones A and B (<b>3</b> and <b>4</b>), and glaucalactone (<b>5</b>), along with the known compounds 3β,21β-dihydroxy-30-nor-(D:A)-friedo-olean-20(29)-en-27-oic acid (<b>6</b>) and acetyltrichadenic acid B (<b>7</b>), were isolated from the leaves of <i>Caloncoba glauca</i>. The structures of <b>1</b>–<b>5</b> were elucidated using spectroscopic methods. Compounds <b>1</b>–<b>7</b> were evaluated for their inhibitory activities against two isozymes of 11β-hydroxysteroid dehydrogenase (11β-HSD1 and 11β-HSD2). Compounds <b>1</b> and <b>2</b> exhibited strong inhibitory activities against mouse (EC₅₀ 132 and 13 nM) and human (EC₅₀ 105 and 72 nM) 11β-HSD1

Additional file 1: of Antimicrobial and antioxidant activities of triterpenoid and phenolic derivatives from two Cameroonian Melastomataceae plants: Dissotis senegambiensis and Amphiblemma monticola

NMR and Mass spectra of isolated compounds from D. senegambiensis and A. monticola. (PDF 1113 kb

Two new flavone glycosides from the leaves of <i>Ochna afzelii</i> Oliv. (Ochnaceae)

Two new glycosylflavones, 6′′-O-acetyl-8-C-β-D-galactopyranosylchrysoeriol (1) and 8-C-β-D-galactopyranosylchrysoeriol (2) were isolated from the methanol extract of the leaves of Ochna afzelii Oliv., along with four known compounds namely 8-C-β-D-galactopyranosylapigenin (3), ochnaflavone (4), sitosterol-3-O-β-D-glucopyranoside (5) and D-mannitol (6). Isolation was performed chromatographically and the structures of the purified compounds were elucidated by analyzing their spectroscopic and mass spectrometric data. The antibacterial activity of extract, fractions, and compounds 1 − 4 was evaluated using broth microdilution method against Gram-positive and Gram-negative bacteria while the antioxidant capacity was performed using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) and the ferric reducing antioxidant power (FRAP) methods. The new flavones (1 and 2) displayed moderate antibacterial activities (MIC = 32 − 64 µg/mL) and weak antioxidant properties.</p