Getting the youth back to the land: Community-based collaborative Archaeology at Tl’ches

Tl’ches is an island group in the Salish Sea near present-day Victoria. As Songhees Nation reserve land, it is an archetypal Cultural Keystone Place that has been inhabited by Lekwungen-speaking families for generations. Ongoing community-based archaeological and ethnoecology research regards this archipelago as an ecosystem shaped by millennia of indigenous resource management and subsistence practices. An ongoing collaborative research project is centred on the community value of “getting the youth back to the land,” and combining community knowledge and priorities with archaeological and historical ecology data and methods. Together we explore indigenous soils, blue camas and spring bank clover root gardens, and a complex of pre-contact and post-contact villages. Importantly, youth are increasingly involved in not just learning, but in contributing to research goals, methods, and practice. Tl’ches offers a complex and robust Lekwungen and environmental record—it is an eco-cultural legacy of sustainable Indigenous inhabitation and management. In effect, it is also simultaneously a place of co-discovery and shared knowledge production

Clinical relevance of host immunity in breast cancer: from TILs to the clinic.

The clinical relevance of the host immune system in breast cancer has long been unexplored. Studies developed over the past decade have highlighted the biological heterogeneity of breast cancer, prompting researchers to investigate whether the role of the immune system in this malignancy is similar across different molecular subtypes of the disease. The presence of high levels of lymphocytic infiltration has been consistently associated with a more-favourable prognosis in patients with early stage triple-negative and HER2-positive breast cancer. These infiltrates seem to reflect favourable host antitumour immune responses, suggesting that immune activation is important for improving survival outcomes. In this Review, we discuss the composition of the immune infiltrates observed in breast cancers, as well as data supporting the clinical relevance of host antitumour immunity, as represented by lymphocytic infiltration, and how this biomarker could be used in the clinical setting. We also discuss the rationale for enhancing immunity in breast cancer, including early data on the efficacy of T-cell checkpoint inhibition in this setting.SCOPUS: re.jinfo:eu-repo/semantics/publishe