Direct demonstration of circulating currents in a controllable π\pi-SQUID generated by a 0 to π\pi transition of the weak links

A controllable $\pi$-SQUID is a DC SQUID with two controllable $\pi$-junctions as weak links. A controllable $\pi$-junction consists of a superconducting - normal metal - superconducting Josephson junction with two additional contacts to the normal region of the junction. By applying a voltage $V_c$ over these contacts it is possible to control the sate of the junction, i.e. a conventional (0) state or a $\pi$-state, depending on the magnitude of $V_c$. We demonstrate experimentally that, by putting one junction into a $\pi$-state, a screening current is generated around the SQUID loop at integer external flux. To be able to do this, we have fabricated controllable $\pi$-junctions, based on Cu-Nb or Ag-Nb, in a new geometry. We show that at 1.4 K only the Nb-Ag device shows the transition to a $\pi$-state as a function of $V_c$ consistent with theoretical predictions. In a controllable $\pi$ SQUID based on Nb-Ag we observe, a part from a screening current at integer external flux, a phase shift of $\pi$ of the $V_{SQUID}-B$ oscillations under suitable current bias, depending on the magnitude of $V_c$.Comment: 11 pages, 12 figures, subm. to Phys. Rev.

Solutions of a particle with fractional δ\delta-potential in a fractional dimensional space

A Fourier transformation in a fractional dimensional space of order \la (0<\la\leq 1) is defined to solve the Schr\"odinger equation with Riesz fractional derivatives of order \a. This new method is applied for a particle in a fractional $\delta$-potential well defined by V(x) =- \gamma\delta^{\la}(x), where $\gamma>0$ and \delta^{\la}(x) is the fractional Dirac delta function. A complete solutions for the energy values and the wave functions are obtained in terms of the Fox H-functions. It is demonstrated that the eigen solutions are exist if 0< \la<\a. The results for \la= 1 and \a=2 are in exact agreement with those presented in the standard quantum mechanics

Genome-Wide Association Study for Type 2 Diabetes in Indians Identifies a New Susceptibility Locus at 2q21

Indians undergoing socioeconomic and lifestyle transitions will be maximally affected by epidemic of type 2 diabetes (T2D). We conducted a two-stage genome-wide association study of T2D in 12,535 Indians, a less explored but high-risk group. We identified a new type 2 diabetes–associated locus at 2q21, with the lead signal being rs6723108 (odds ratio 1.31; P = 3.32 3 1029 ). Imputation analysis refined the signal to rs998451 (odds ratio 1.56; P = 6.3 3 10212) within TMEM163 that encodes a probable vesicular transporter in nerve terminals. TMEM163 variants also showed association with decreased fasting plasma insulin and homeostatic model assessment of insulin resistance, indicating a plausible effect through impaired insulin secretion. The 2q21 region also harbors RAB3GAP1 and ACMSD; those are involved in neurologic disorders. Forty-nine of 56 previously reported signals showed consistency in direction with similar effect sizes in Indians and previous studies, and 25 of them were also associated (P , 0.05). Known loci and the newly identified 2q21 locus altogether explained 7.65% variance in the risk of T2D in Indians. Our study suggests that common susceptibility variants for T2D are largely the same across populations, but also reveals a population-specific locus and provides further insights into genetic architecture and etiology of T2D

Adolescent inhalant abuse results in adrenal dysfunction and a hypermetabolic phenotype with persistent growth impairments

Abstract not availableRose Crossin, Zane B. Andrews, Natalie A. Sims, Terence Pang, Michael Mathai, Jonathan H. Gooi, Aneta Stefanidis, Brian J. Oldfield, Andrew J. Lawrence, Jhodie R. Dunca