Research of the relationship between the economic macroindicators of singleindustry city and aggregated indicators of small business

The report describes the research of dependencies between socio-economic macroindicators of the monogorod Yurga and the financial and economic indicators of small enterprises

Medium-chain acyl-CoA dehydrogenase deficiency in gene-targeted mice

Medium-chain acyl-CoA dehydrogenase (MCAD) deficiency is the most common inherited disorder of mitochondrial fatty acid β-oxidation in humans. To better understand the pathogenesis of this disease, we developed a mouse model for MCAD deficiency (MCAD-/-) by gene targeting in embryonic stem (ES) cells. The MCAD-/- mice developed an organic aciduria and fatty liver, and showed profound cold intolerance at 4 °C with prior fasting. The sporadic cardiac lesions seen in MCAD-/- mice have not been reported in human MCAD patients. There was significant neonatal mortality of MCAD -/- pups demonstrating similarities to patterns of clinical episodes and mortality in MCAD-deficient patients. The MCAD-deficient mouse reproduced important aspects of human MCAD deficiency and is a valuable model for further analysis of the roles of fatty acid oxidation and pathogenesis of human diseases involving fatty acid oxidation. © 2005 Tolwani et al

Examination of macro- and microelements distribution between total extract and fractions for nootropic plant-derived raw material Alfredia cernua

The paper dwells on a quantitative determination of macro- and microelements in the ethanol Alfredia cernua extract and its chloroform, ethyl acetate, and butanol fractions. The distribution of macro- and microelements in the extract and fractions was investigated to further study of the interrelation between chemical composition and nootropic activity Alfredia cernua. It is shown that B, Fe, and Sn is mainly accumulated in butanol and Si, P, Al - in chloroform fraction respectively, but most macro- and microelements remain in the ethanol extract

МЕТОДИЧНІ ВКАЗІВКИ ДО ПРАКТИЧНИХ ЗАНЯТЬ З НАВЧАЛЬНОЇ ДИСЦИПЛІНИ «ОСОБЛИВОСТІ ПЕРЕКЛАДУ ХУДОЖНІХ ТВОРІВ»

Подано методичні вказівки до практичних занять магістрів з курсу «Особливості перекладу художніх творів», які містять перелік основних питань, які повинні бути опрацьовані та засвоєні студентом, перелік літератури для опрацювання матеріалу. Призначено для магістрів з напрямку підготовки 6.020303 «Філологія», спеціальності 8.02030304 «Переклад»

Организация работ по охране труда и оценка рисков работников нефтегазодобывающего предприятия

Несмотря на усовершенствование технологических процессов и вводимые меры по обеспечению безопасности труда, на предприятиях существует тенденция к снижению себестоимости продукции. В связи с этим увеличивается вероятность возникновения производственных рисков на промышленных предприятиях, которые рассмотрены в данной работе на примере нефтегазодобывающего управления "Федоровскнефть".Despite the improvement of technological processes and the introduction of measures to ensure labor safety, there is a tendency at enterprises to reduce the cost of production. In this connection, the probability of occurrence of industrial risks in industrial enterprises is increased, which are considered in this work by the example of oil and gas production department "Fedorovskneft"

Асинхронный электропривод шахтного вентилятора

В данной работе были рассмотрены общие вопросы шахтной вентиляции, приведены основные типы шахтных вентиляторов и требования к ним. В работе произведен расчёт и исследование электропривода вентилятора. Смоделированы и исследованы переходные процессы регулируемого электропривода в среде Matlab SimulinkIn this work the common questions of mine ventilation were considered, the main types of mine fans and the requirement to them are given. In work calculation and a research of the electric drive of the fan is made. Transient phenomenons of the adjustable electric drive in the environment of Matlab Simulink are simulated and investigate

Moonlighting Newborn Screening Markers: The Incidental Discovery of a Second-Tier Test for Pompe Disease

Purpose: To describe a novel biochemical marker in dried blood spots suitable to improve the specificity of newborn screening for Pompe disease. Methods: The new marker is a ratio calculated between the creatine/creatinine (Cre/Crn) ratio as the numerator and the activity of acid α-glucosidase (GAA) as the denominator. Using Collaborative Laboratory Integrated Reports (CLIR), the new marker was incorporated in a dual scatter plot that can achieve almost complete segregation between Pompe disease and false-positive cases. Results: The (Cre/Crn)/GAA ratio was measured in residual dried blood spots of five Pompe cases and was found to be elevated (range 4.41–13.26; 99%ile of neonatal controls: 1.10). Verification was by analysis of 39 blinded specimens that included 10 controls, 24 samples with a definitive classification (16 Pompe, 8 false positives), and 5 with genotypes of uncertain significance. The CLIR tool showed 100% concordance of classification for the 24 known cases. Of the remaining five cases, three p.V222M homozygotes, a benign variant, were classified by CLIR as false positives; two with genotypes of unknown significance, one likely informative, were categorized as Pompe disease. Conclusion: The CLIR tool inclusive of the new ratio could have prevented at least 12 of 13 (92%) false-positive outcomes