23 research outputs found
Clinical Characteristics and Outcomes of Very Elderly Patients With Atrial Fibrillation at High Bleeding Risk - The Fushimi AF Registry
Introduction to Community Service-Learning (SRCL 1000)
Introduction to Community Service-Learning is a general elective open to first to fourth year international and domestic students from a variety of disciplines across campus. Every fall and winter semester each student volunteers at one of 30 local not-for-profit organizations for a full semester. Students are required to complete 24 hours of service as part of their course work. In this poster session, 16 not-for-profit organizations will be represented by 27 SRCL 1000 students. They will demonstrate personal reflections on their service experiences, how their experiences connect to the course work and their organizations, and what they will take back to their own communities after the course is over.
Students representing the following Kamloops not-for-profit organizations:
Active Care Services: Nolan Fenrich
St. John Ambulance: Damilola Abiyo and Ryuki Furuta
Overlander Residential Care: Glory Amukamara
Ponderosa Lodge: Rahab Kariuki
The Kamloops Food Bank: Yu Cao, Surkamal Singh Jhand, Xiangzhong Kong and Ruotong Shi
The ReStore – Habitat for Humanity: Dion Maborekhe, Fengyi Yang and Haonan Deng
Kamloops Immigrant Services: Dipak Parmar
Maple Leaf School: Qian Wang and Mengyao Zhu
BC SPCA: Dawei Xu
TRU Sustainability Office: Akash Ghosh, Takaya Hirose, Jihoon Kim and Kosuke Masunaga
TRU Horticulture: Ols Buta
TRU The X Radio: Marie Gabriela Jimenez and MD Majharul Islam Sabuj
Beattie School of the Arts: Makoto Iida
Gemstone Care Center: Tirth Panchal
Chartwell Ridgepointe: Sakina Shikama
Sikh Temple: Gurpreet Pua
Crystalline Graphdiyne Nanosheets Produced at a Gas/Liquid or Liquid/Liquid Interface
Synthetic two-dimensional
polymers, or bottom-up nanosheets, are
ultrathin polymeric frameworks with in-plane periodicity. They can
be synthesized in a direct, bottom-up fashion using atomic, ionic,
or molecular components. However, few are based on carbon–carbon
bond formation, which means that there is a potential new field of
investigation into these fundamentally important chemical bonds. Here,
we describe the bottom-up synthesis of all-carbon, π-conjugated
graphdiyne nanosheets. A liquid/liquid interfacial protocol involves
layering a dichloromethane solution of hexaethynylbenzene on an aqueous
layer containing a copper catalyst at room temperature. A multilayer
graphdiyne (thickness, 24 nm; domain size, >25 ÎĽm) emerges
through
a successive alkyne–alkyne homocoupling reaction at the interface.
A gas/liquid interfacial synthesis is more successful. Sprinkling
a very small amount of hexaethynylbenzene in a mixture of dichloromethane
and toluene onto the surface of the aqueous phase at room temperature
generated single-crystalline graphdiyne nanosheets, which feature
regular hexagonal domains, a lower degree of oxygenation, and uniform
thickness (3.0 nm) and lateral size (1.5 ÎĽm)
Crystalline Graphdiyne Nanosheets Produced at a Gas/Liquid or Liquid/Liquid Interface
Synthetic two-dimensional
polymers, or bottom-up nanosheets, are
ultrathin polymeric frameworks with in-plane periodicity. They can
be synthesized in a direct, bottom-up fashion using atomic, ionic,
or molecular components. However, few are based on carbon–carbon
bond formation, which means that there is a potential new field of
investigation into these fundamentally important chemical bonds. Here,
we describe the bottom-up synthesis of all-carbon, π-conjugated
graphdiyne nanosheets. A liquid/liquid interfacial protocol involves
layering a dichloromethane solution of hexaethynylbenzene on an aqueous
layer containing a copper catalyst at room temperature. A multilayer
graphdiyne (thickness, 24 nm; domain size, >25 ÎĽm) emerges
through
a successive alkyne–alkyne homocoupling reaction at the interface.
A gas/liquid interfacial synthesis is more successful. Sprinkling
a very small amount of hexaethynylbenzene in a mixture of dichloromethane
and toluene onto the surface of the aqueous phase at room temperature
generated single-crystalline graphdiyne nanosheets, which feature
regular hexagonal domains, a lower degree of oxygenation, and uniform
thickness (3.0 nm) and lateral size (1.5 ÎĽm)
Gamma-glutamyltransferase activity in exosomes as a potential marker for prostate cancer
Abstract Background Exosomes or extracellular vesicles have the potential as a diagnostic marker for various diseases including cancer. In order to identify novel exosomal markers for prostate cancer (PC), we performed proteomic analysis of exosomes isolated from PC cell lines and examined the usefulness of the marker in patients. Methods Exosomes isolated by differential centrifugation from the culture medium of androgen-dependent LNCaP prostate cancer cell line and its sublines of partially androgen-independent C4, androgen-independent C4–2 and bone metastatic C4–2B were subjected to iTRAQ-based proteomic analysis. Exosomes were also isolated by immunocapture and separated by size exclusion chromatography and density gradient centrifugation. Protein expression was determined by Western blot analysis. GGT activity was measured using a fluorescent probe, γ-glutamyl hydroxymethyl rhodamine green (gGlu-HMRG). Immunohistochemical analysis of tissues was performed using anti-GGT1 antibody. Results Among proteins upregulated in C4–2 and C4–2B cells than in LNCaP cells, we focused on gamma-glutamyltransferase 1 (GGT1), a cell-surface enzyme that regulates the catabolism of extracellular glutathione. The levels of both GGT1 large and small subunits were elevated in exosomes isolated from C4–2 and C4–2B cells by differential centrifugation and by immunocapture with anti-CD9 or -prostate-specific membrane antigen (PSMA) antibody. In cell lysates and exosomes, GGT1 expression correlated with GGT activity. Size exclusion chromatography of human serum demonstrated the presence of GGT activity and GGT1 subunits in fractions positive for CD9. Density gradient centrifugation revealed the co-presence of GGT1 subunits with CD9 in exosomes isolated by differential centrifugation from human serum. Since GGT activity correlated with GGT1 expression in serum exosomes isolated by differential centrifugation, we measured serum exosomal GGT activity in patients. Unexpectedly, we found that serum exosomal GGT activity was significantly higher in PC patients than in benign prostatic hyperplasia (BPH) patients. In support of this finding, immunohistochemical analysis showed increased GGT1 expression in PC tissues compared with BPH tissues. Conclusions Our results suggest that serum exosomal GGT activity could be a useful biomarker for PC