The Ursinus Weekly, March 13, 1961

U.N. official speaks on Africa • Aviation team to visit; Group on campus Mar. 22 • Two frosh girls complete Spring Festival court • Committee set up to plan first Parents Day • State Department seeks people for jobs • Mr. Barrie\u27s etchings chosen as Spring play • Listings for March job interviews are posted • Ursinus to host SPSEA convention on Sat., March 18 • WAA investigates insurance plan • Music fraternity invites three people to join • CAC to present second music night on March 18 • Archaeology & the Bible topic of Wed. Y program • Two one-act plays offered in Phila. • Four seniors accepted for teaching positions • Annual Weekly banquet to be held on Thursday • Business Club plans visit to Vic Chemical • Editorial: An unfortunate situation • Letters to the editor • Pleasure and the hedonists • Mistake of the misfits • Reviews: Senior show; Just how mad can you be? • Dryfoos elected to ASCD 1st team • Mermaids down Chestnut Hill • Alpha Phi Epsilon defeats South Hall 83-56 to capture intramural title • Girls downed by Beaver, beat West Chester gals • Chapel commentary • Greek gleaningshttps://digitalcommons.ursinus.edu/weekly/1336/thumbnail.jp

Observations of downwelling far-infrared emission at Table Mountain California made by the FIRST instrument

AbstractThe Far-Infrared Spectroscopy of the Troposphere (FIRST) instrument measured downwelling far-infrared (far-IR) and mid-infrared (mid-IR) atmospheric spectra from 200 to 800cm−1 at Table Mountain, California (elevation 2285m). Spectra were recorded during a field campaign conducted in early autumn 2012, subsequent to a detailed laboratory calibration of the instrument. Radiosondes launched coincident with the FIRST observations provide temperature and water vapor profiles for model simulation of the measured spectra. Results from the driest day of the campaign (October 19, with less than 3mm precipitable water) are presented here. Considerable spectral development is observed between 400 and 600cm−1. Over 90% of the measured radiance in this interval originates within 2.8km of the surface. The existence of temperature inversions close to the surface necessitates atmospheric layer thicknesses as fine as 10m in the radiative transfer model calculations. A detailed assessment of the uncertainties in the FIRST measurements and in the model calculations shows that the measured radiances agree with the model radiance calculations to within their combined uncertainties. The uncertainties in modeled radiance are shown to be larger than the measurement uncertainties. Overall, the largest source of uncertainty is in the water vapor concentration used in the radiative transfer calculations. Proposed new instruments with markedly higher measurement accuracy than FIRST will be able to measure the far-IR spectrum to much greater accuracy than it can be computed. As such, accurate direct measurements of the far-IR, and not solely calculations, are essential to the assessment of climate change

ELECTRON AVALANCHE IN LIQUID XENON

We present detailed measurements of the electron avalanche process in liquid Xenon. The measurements were made by using liquid-Xe-filled proportional chambers with anode diameters of 2.9, 3.5, and 5.0 {approx} to detect 279-keV y rays and measure the photopeak pulse height as a function of applied voltage. The use of uniform pulses of electrons enabled us to discriminate against secondary Townsend processes. We present a table of the first Townsend coefficient a as a function of electric field E; a typical value is {alpha} = (4.5 {+-} 0.3) x 10{sup 4} cm{sup -1} at E = 2 x 10{sup 6} V/cm. The electron avalanche occurs in liquid Xe at electric fields 26 times smaller than would be predicted using measurements made in gaseous Xe and E/{rho} density scaling

Experience and results after the implementation of a radiology day unit in a reference hospital

Hospitals; Radiology (Interventional); Surveys and questionariesHospitals; Radiologia (intervencionista); Enquestes i preguntesHospitales; Radiología (Intervencionista); Encuestas y cuestionariosBackground Interventional radiological procedures have significantly increased in recent years. Most of them are minimally invasive and require a short hospitalization, mainly done in other non-radiological units nowadays. Limited bed availability and high occupancy rates in these units create longer waiting lists and cancellations. The aim of this retrospective study is to assess the creation and functioning of a Radiology Day Unit (RDU) and evaluating its outcomes. For this purpose, data about interventional procedures and its complications, incidents, patient safety, quality and satisfaction rates were collected from May 2018 to December 2020, and posteriorly analyzed to evaluate its implementation. Results During the assessed period, 3841 patients were admitted into the RDU, with a net increase of 13% and 26% in the second and third year, respectively. Procedures performed by the Abdominal Radiology section were the most frequent (76–85%) followed by Interventional Vascular Radiology and Thoracic Radiology. Complication rates were low (1.5%) and most of them were self-limited and managed in the own department. Waiting lists were significantly reduced, from 2 months to 1 week in case of procedures performed by the Abdominal Radiology section. Patient satisfaction was higher than 80% in all the items evaluated with a global satisfaction of 93%. Conclusion The RDU in our hospital has become a vital section for the management and post-procedure caring of patients undergoing interventional procedures in the Radiology Service with low complication rates and overall high levels of quality and patient safety, allowing the reduction of waiting lists and occupancy rates

The current recommendation for the management of isolated high-grade prostatic intraepithelial neoplasia

Altres ajuts: Acord transformatiu CRUE-CSICObjective: To analyse the current predictive value of isolated high-grade prostatic intraepithelial neoplasia (HGPIN) for clinically significant prostate cancer (csPCa) detection in repeat biopsies. Patients and Methods: A cohort of 293 men with isolated HGPIN detected in previous biopsies performed without multiparametric magnetic resonance imaging (mpMRI), and who underwent repeat biopsy within 1 to 3 years, was analysed. Pre-repeat biopsy mpMRI and guided biopsies to suspicious lesions (Prostate Imaging - Reporting and Data System [PI-RADS] ≥3) and/or and systematic biopsies were performed. Persistent prostate cancer (PCa) suspicion, defined as sustained serum prostatespecific antigen level >4 ng/mL and/or abnormal digital rectal examination, was present in 248 men (84.6%), and was absent in 45 men (15.4%). A control group of 190 men who had no previous HGPIN, atypical small acinar proliferation or HGPIN with atypia who were scheduled to undergo repeat biopsy due to persistent PCa suspicion were also analysed. csPCa was defined as tumours of Grade Group ≥2.Results: In the subset of 45 men with isolated HGPIN, in whom PCa suspicion disappeared, only one csPCa (2.2%) and one insignificant PCa (iPCa) were detected. csPCa was detected in 34.7% of men with persistent PCa suspicion and previous HGPIN, and in 28.4% of those without previous HGPIN (P =0.180). iPCa was detected in 12.1% and 6.3%, respectively (P =0.039). Logistic regression analysis showed that the risk of csPCa detection was not predicted by previous HGPIN: odds ratio (OR) 1.369 (95% confidence interval [CI] 0.894-2.095; P =0.149); however, previous HGPIN increased the risk of iPCa detection: OR 2.043 (95% CI 1.016-4.109; P =0.006). Conclusion: The risk of csPCa in men with isolated HGPIN, in whom PCa suspicion disappears, is extremely low. Moreover, in those men in whom PCa suspicion persists, the risk of csPCa is not influenced by the previous finding of HGPIN. However, previous HGPIN increases the risk of iPCa detection. Therefore, repeat prostate biopsy should not be recommended solely because of a previous HGPIN

Genome-wide analysis of signaling networks regulating fatty acid–induced gene expression and organelle biogenesis

Reversible phosphorylation is the most common posttranslational modification used in the regulation of cellular processes. This study of phosphatases and kinases required for peroxisome biogenesis is the first genome-wide analysis of phosphorylation events controlling organelle biogenesis. We evaluate signaling molecule deletion strains of the yeast Saccharomyces cerevisiae for presence of a green fluorescent protein chimera of peroxisomal thiolase, formation of peroxisomes, and peroxisome functionality. We find that distinct signaling networks involving glucose-mediated gene repression, derepression, oleate-mediated induction, and peroxisome formation promote stages of the biogenesis pathway. Additionally, separate classes of signaling proteins are responsible for the regulation of peroxisome number and size. These signaling networks specify the requirements of early and late events of peroxisome biogenesis. Among the numerous signaling proteins involved, Pho85p is exceptional, with functional involvements in both gene expression and peroxisome formation. Our study represents the first global study of signaling networks regulating the biogenesis of an organelle

Safety of Obtaining an Extra Biobank Kidney Biopsy Core

Biobank; Chronic kidney disease; Kidney biopsyBiobanco; Enfermedad renal cronica; Biopsia renalBiobanc; Malaltia renal crònica; Biòpsia de ronyóBackground and objectives: Kidney biopsy (KB) is the “gold standard” for the diagnosis of nephropathies and it is a diagnostic tool that presents a low rate of complications. Nowadays, biobank collections of renal tissue of patients with proven renal pathology are essential for research in nephrology. To provide enough tissue for the biobank collection, it is usually needed to obtain an extra kidney core at the time of kidney biopsy. The objective of our study is to evaluate the complications after KB and to analyze whether obtaining an extra core increases the risk of complications. Material and methods: Prospective observational study of KBs performed at Vall d’Hebron Hospital between 2019 and 2020. All patients who accepted to participate to our research biobank of native kidney biopsies were included to the study. Clinical and laboratory data were reviewed and we studied risk factors associated with complications. Results: A total of 221 patients were included, mean age 56.6 (±16.8) years, 130 (58.8%) were men, creatinine was 2.24 (±1.94) mg/dL, proteinuria 1.56 (0.506–3.590) g/24 h, hemoglobin 12.03 (±2.3) g/dL, INR 0.99 (±0.1), and prothrombin time (PT) 11.86 (±1.2) s. A total of 38 patients (17.2%) presented complications associated with the procedure: 13.1% were minor complications, 11.3% (n = 25) required blood transfusion, 1.4% (n = 3) had severe hematomas, 2.3% (n = 5) required embolization, and 0.5% (n = 1) presented arterio-venous fistula. An increased risk for complication was independently associated with obtaining a single kidney core (vs. 2 and 3 cores) (p = 0.021). Conclusions: KB is an invasive and safe procedure with a low percentage of complications. Obtaining an extra kidney core for research does not increase the risk of complications during the intervention, which remains low in concordance with previously published reports.The authors are current recipients of research grant from Red de Investigación Renal (REDINREN, RD16/0009/0030). (RICORS, RD21/0005/0016)

Who with suspected prostate cancer can benefit from Proclarix after multiparametric magnetic resonance imaging?

Cathepsin D; Magnetic resonance imaging; ProclarixCatepsina D; Imatges per ressonància magnètica; ProclarixCatepsina D; Imágenes por resonancia magnética; ProclarixProclarix is a new blood-based test to assess the likelihood of clinically significant prostate cancer (csPCa) defined as >2 grade group. In this study, we analyzed whether Proclarix and PSA density (PSAD) could improve the selection of candidates for prostate biopsy after multiparametric magnetic resonance imaging (mpMRI). Proclarix and PSAD were assessed in 567 consecutive men with suspected PCa in whom pre-biopsy 3 Tesla mpMRI, scoring with Prostate Imaging-Report and Data System (PI-RADS) v.2, and guided and/or systematic biopsies were performed. Proclarix and PSAD thresholds having csPCa sensitivity over 90% were found at 10% and 0.07 ng/(mL*cm3), respectively. Among 100 men with negative mpMRI (PI-RADS <3), csPCa was detected in 6 cases, which would have been undetected if systematic biopsies were avoided. However, Proclarix suggested performing a biopsy on 70% of men with negative mpMRI. In contrast, PSAD only detected 50% of csPCa and required 71% of prostate biopsies. In 169 men with PI-RADS 3, Proclarix avoided 21.3% of prostate biopsies and detected all 25 cases of csPCa, while PSAD avoided 26.3% of biopsies, but missed 16% of csPCa. In 190 men with PI-RADS 4 and 108 with PI-RADS 5, Proclarix avoided 12.1% and 5.6% of prostate biopsies, but missed 4.8% and 1% of csPCa, respectively. PSAD avoided 18.4% and 9.3% of biopsies, but missed 11.4% and 4.2% csPCa, respectively. We conclude that Proclarix outperformed PSAD in the selection of candidates for prostate biopsy, especially in men with PI-RADS <3.The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the Instituto de Salud Carlos III, (grant number PI20/01666)

The Efficacy of Proclarix to Select Appropriate Candidates for Magnetic Resonance Imaging and Derived Prostate Biopsies in Men with Suspected Prostate Cancer

Diagnosis; Proclarix; Prostate cancerDiagnóstico; Proclarix; Cáncer de próstataDiagnòstic; Proclarix; Càncer de pròstataPurpose To analyze how Proclarix is valuable to appropriately select candidates for multiparametric magnetic resonance imaging (mpMRI) and derived biopsies, among men with suspected prostate cancer (PCa). Proclarix is a new marker computing the clinically significant PCa (csPCa) risk, based on serum thosmbospondin-1, cathepsin D, prostate-specific antigen (PSA) and percent free PSA, in addition to age, that has been developed in men with serum PSA 2 to 10 ng/mL, prostate volume ≥35 mL, and normal digital rectal examination (DRE). Materials and Methods Proclarix score (0%–100%) is analyzed in a prospective frozen serum collection of 517 correlative men scheduled for guided and/or systematic biopsies after mpMRI. Outcome variables were csPCa detection (grade group ≥2), insignificant PCa (iPCa) overdetection and avoided mpMRIs. Results The area under the curve of Proclarix was 0.701 (95% CI 0.637–0.765) among 281 men with serum PSA 2 to 10 ng/mL, prostate volume ≥35 mL, and -normal DRE, and 0.754 (95% CI 0.701–0.807) in the others, p=0.038. Net benefit of Proclarix existed in all men. After selecting 10% threshold, Proclarix was integrated in an algorithm which also used the serum PSA level and DRE. A reduction of 25.4% of mpMRIs request was observed and 17.7% of prostate biopsies. Overdetection of iPCa was reduced in 18.2% and 2.6% of csPCa were misdiagnosed. Conclusions Proclarix is valuable in all men with suspected PCa. An algorithm integrating Proclarix score, serum PSA, and DRE can avoid mpMRI requests, unnecessary prostate biopsies and iPCa overdetection, with minimal loss of csPCa detection