Moderator analysis: compliance with 24-hour sepsis bundle (k = 11).

<p>*p<0.05</p><p>**p<0.01</p><p>***p<0.001</p><p>^a p for comparison between subgroups</p><p>Moderator analysis: compliance with 24-hour sepsis bundle (k = 11).</p

Moderator analysis: compliance with the complete 6-hour sepsis bundle (k = 25).

<p>*p<0.05</p><p>**p<0.01</p><p>***p<0.001</p><p>^a p for comparison between subgroups</p><p>Moderator analysis: compliance with the complete 6-hour sepsis bundle (k = 25).</p

Forest plot showing individual and overall ES of studies that evaluated changes in mortality following the implementation of the performance improvement program (k = 48).

<p>The size of the boxes is inversely proportional to the size of the result study variance, so that more precise studies have larger boxes. The ES is expressed as odds ratio (OR) and the correspondent 95% confidence interval (CI). An OR below 1.00 (left side of the plot) indicates an association between the intervention and decreased mortality. ES = effect size; CI = confidence interval; Sig. = p value.</p

Sepsis bundles.

<p>Sepsis bundles.</p

Forest plots showing individual and overall ES of studies that evaluated changes in compliance with individual 24-hour bundle targets following the implementation of the performance improvement program. (A) Lung protective ventilation (k = 9); (B) Steroids (k = 20); (C) Drotrecogin alfa (activated) (k = 16); (D) Glucose control (k = 13).

<p>The size of the boxes is inversely proportional to the size of the result study variance, so that more precise studies have larger boxes. The ES is expressed as odds ratio (OR) and the correspondent 95% confidence interval (CI). An OR above 1.00 (right side of the plot) indicates an association between the intervention and increased compliance. ES = effect size; CI = confidence interval; Sig. = p value.</p

Forest plots showing individual and overall ES of studies that evaluated changes in compliance with individual 6-hour bundle targets following the implementation of the performance improvement program. (A) Measure lactate (k = 31); (B) Blood cultures (k = 28); (C) Antibiotics (k = 35); (D) Fluid resuscitation (k = 24).

<p>The size of the boxes is inversely proportional to the size of the result study variance, so that more precise studies have larger boxes. The ES is expressed as odds ratio (OR) and the correspondent 95% confidence interval (CI). An OR above 1.00 (right side of the plot) indicates an association between the intervention and increased compliance. ES = effect size; CI = confidence interval; Sig. = p value.</p

Forest plots showing individual and overall ES of studies that evaluated changes in compliance with individual 6-hour bundle targets following the implementation of the performance improvement program. (A) Measure central venous pressure (k = 8); (B) Central venous pressure above 8 mmHg (k = 16); (C) Measure SvO₂ (k = 8); (D) SvO₂ above 70% (k = 15); (E) Mean arterial pressure above 65 mmHg (k = 9); (F) Use of vasopressors (k = 9).

<p>The size of the boxes is inversely proportional to the size of the result study variance, so that more precise studies have larger boxes. The ES is expressed as odds ratio (OR) and the correspondent 95% confidence interval (CI). An OR above 1.00 (right side of the plot) indicates an association between the intervention and increased compliance. ES = effect size; CI = confidence interval; Sig. = p value.</p

Moderator analysis of studies that evaluated changes in mortality following the performance improvement program (k = 48).

<p>*p<0.05</p><p>**p<0.01</p><p>***p<0.001</p><p>^a p for comparison between subgroups</p><p>Moderator analysis of studies that evaluated changes in mortality following the performance improvement program (k = 48).</p

Forest plot showing individual and overall ES of studies that evaluated changes in compliance with the complete 6-hour bundle following the implementation of the performance improvement program (k = 25).

<p>The size of the boxes is inversely proportional to the size of the result study variance, so that more precise studies have larger boxes. The ES is expressed as odds ratio (OR) and the correspondent 95% confidence interval (CI). An OR above 1.00 (right side of the plot) indicates an association between the intervention and increased compliance. ES = effect size; CI = confidence interval; Sig. = p value.</p

Microorganisms isolated in blood cultures.

<p>Microorganisms isolated in blood cultures.</p