Breast Ultra-Sound image segmentation: an optimization approach based on super-pixels and high-level descriptors

International audienceBreast cancer is the second most common cancer and the leading cause of cancer death among women. Medical imaging has become an indispensable tool for its diagnosis and follow up. During the last decade, the medical community has promoted to incorporate Ultra-Sound (US) screening as part of the standard routine. The main reason for using US imaging is its capability to differentiate benign from malignant masses, when compared to other imaging techniques. The increasing usage of US imaging encourages the development of Computer Aided Diagnosis (CAD) systems applied to Breast Ultra-Sound (BUS) images. However accurate delineations of the lesions and structures of the breast are essential for CAD systems in order to extract information needed to perform diagnosis. This article proposes a highly modular and flexible framework for segmenting lesions and tissues present in BUS images. The proposal takes advantage of optimization strategies using super-pixels and high-level de-scriptors, which are analogous to the visual cues used by radiologists. Qualitative and quantitative results are provided stating a performance within the range of the state-of-the-art

An optimization approach to segment breast lesions in ultra-sound images using clinically validated visual cues

International audienceAs long as breast cancer remains the leading cause of cancer deaths among female population world wide, developing tools to assist radiologists during the diagnosis process is necessary. However, most of the technologies developed in the imaging laboratories are rarely integrated in this assessing process, as they are based on information cues differing from those used by clinicians. In order to grant Computer Aided Diagnosis (CAD) systems with these information cues when performing non-aided diagnosis, better segmentation strategies are needed to automatically produce accurate delineations of the breast structures. This paper proposes a highly modular and flexible framework for segmenting breast tissues and lesions present in Breast Ultra-Sound (BUS) images. This framework relies on an optimization strategy and high-level de-scriptors designed analogously to the visual cues used by radiologists. The methodology is comprehensively compared to other sixteen published methodologies developed for segmenting lesions in BUS images. The proposed methodology achieves similar results than reported in the state-of-the-art

Classification of SD-OCT Volumes with LBP: Application to DME Detection

This paper addresses the problem of automatic classification of Spectral Domain OCT (SD-OCT) data for automatic identification of patients with Diabetic Macular Edema (DME) versus normal subjects. Our method is based on Local Binary Patterns (LBP) features to describe the texture of Optical Coherence Tomography (OCT) images and we compare different LBP features extraction approaches to compute a single signature for the whole OCT volume. Experimental results with two datasets of respectively 32 and 30 OCT volumes show that regardless of using low or high level representations, features derived from LBP texture have highly discriminative power. Moreover, the experiments show that the proposed method achieves better classification performances than other recent published works

Classifying DME vs Normal SD-OCT volumes: A review

International audienceThis article reviews the current state of automatic classification methodologies to identify Diabetic Macular Edema (DME) versus normal subjects based on Spectral Domain OCT (SD-OCT) data. Addressing this classification problem has valuable interest since early detection and treatment of DME play a major role to prevent eye adverse effects such as blindness. The main contribution of this article is to cover the lack of a public dataset and benchmark suited for classifying DME and normal SD-OCT volumes, providing our own implementation of the most relevant methodologies in the literature. Subsequently, 6 different methods were implemented and evaluated using this common benchmark and dataset to produce reliable comparison

Normalization of T2W-MRI Prostate Images using Rician a priori

International audienceProstate cancer is reported to be the second most frequently diagnosed cancer of men in the world. In practise, diagnosis can be affected by multiple factors which reduces the chance to detect the potential lesions. In the last decades, new imaging techniques mainly based on MRI are developed in conjunction with Computer-Aided Diagnosis (CAD) systems to help radiologists for such diagnosis. CAD systems are usually designed as a sequential process consisting of four stages: pre-processing, segmentation, registration and classification. As a pre-processing, image normalization is a critical and important step of the chain in order to design a robust classifier and overcome the inter-patients intensity variations. However, little attention has been dedicated to the normalization of T2W-Magnetic Resonance Imaging (MRI) prostate images. In this paper, we propose two methods to normalize T2W-MRI prostate images: (i) based on a Rician a priori and (ii) based on a Square-Root Slope Function (SRSF) representation which does not make any assumption regarding the Probability Density Function (PDF) of the data. A comparison with the state-of-the-art methods is also provided. The normalization of the data is assessed by comparing the alignment of the patient PDFs in both qualitative and quantitative manners. In both evaluation, the normalization using Rician a priori outperforms the other state-of-the-art methods

Tackling the Problem of Data Imbalancing for Melanoma Classification

International audienceMalignant melanoma is the most dangerous type of skin cancer, yet melanoma is the most treatable kind of cancer when diagnosed at an early stage. In this regard, Computer-Aided Diagnosis systems based on machine learning have been developed to discern melanoma lesions from benign and dysplastic nevi in dermoscopic images. Similar to a large range of real world applications encountered in machine learning, melanoma classification faces the challenge of imbalanced data, where the percentage of melanoma cases in comparison with benign and dysplastic cases is far less. This article analyzes the impact of data balancing strategies at the training step. Subsequently, Over-Sampling (OS) and Under-Sampling (US) are extensively compared in both feature and data space, revealing that NearMiss-2 (NM2) outperform other methods achieving Sensitivity (SE) and Specificity (SP) of 91.2% and 81.7%, respectively. More generally, the reported results highlight that methods based on US or combination of OS and US in feature space outperform the others

Wood fiber orientation assessment based on punctual laser beam excitation: A preliminary study

International audienceThe EU imposes standards for the use of wood in structural applications. Local singularities such as knots affect the wood mechanical properties. They can be revealed by looking at the wood fiber orientation. For this reason, many methods were proposed to estimate the orientation of wood fiber using optical means, X-rays, or scattering measurement techniques. In this paper, an approach to assess the wood fiber orientation based on thermal ellipsometry is developed. The wood part is punctually heated with a Nd-YAG Laser and the thermal response is acquired by an infrared camera. The thermal response is elliptical due to the propagation of the heat through and along the wood fibers. An experiment is presented to show the capacity of such techniques to assess fiber orientation on wood specimen. In addition, an appropriate algorithm is given to extract the orientation of the ellipse

Classification of SD-OCT Volumes using Local Binary Patterns: Experimental Validation for DME Detection

International audienceThis paper addresses the problem of automatic classification of Spectral Domain OCT (SD-OCT) data for automatic identification of patients with Diabetic Macular Edema (DME) versus normal subjects. Optical Coherence Tomography (OCT) has been a valuable diagnostic tool for DME, which is among the most common causes of irreversible vision loss in individuals with diabetes. Here, a classification framework with five distinctive steps is proposed and we present an extensive study of each step. Our method considers combination of various pre-processings in conjunction with Local Binary Patterns (LBP) features and different mapping strategies. Using linear and non-linear classifiers, we tested the developed framework on a balanced cohort of 32 patients. Experimental results show that the proposed method outperforms the previous studies by achieving a Sensitivity (SE) and Specificity (SP) of 81.2% and 93.7%, respectively. Our study concludes that the 3D features and high-level representation of 2D features using patches achieve the best results. However, the effects of pre-processing is inconsistent with respect to different classifiers and feature configurations

Classification of SD-OCT volumes with multi pyramids, LBP and HOG descriptors: application to DME detections

International audienceThis paper deals with the automated detection of DME on OCT volumes.Our method considers a generic classification pipeline with preprocessing for noise removal and flattening of each B-Scan.Features such as HoG and LBP are extracted and combined to create a set of different feature vectors which are fed to a linear-SVM classifier.Experimental results show a promising sensitivity/specificity of 0.75/0.87 on a challenging dataset