COIN Doctrine Is Wrong

Counterinsurgency does not increase the legitimacy of, or support for, central governments engaged in internal conflicts. Recent research shows quantifiable degrees of government legitimacy, national identity, and population security are necessary precursors and accurate predictors of a government’s ability to outlast a civil uprising. Because the first two predictors—government legitimacy and national identity—can be measured and do not increase during a conflict, the probability of government failure in most cases can be accurately predicted when the conflict starts

Recommendations for Success in Afghanistan

The United States will soon enter the 18th year of combat operations in Afghanistan. During that time, multiple approaches to stabilize the country have been tried, including support to regional security initiatives, “nation-building,” counterinsurgency, counternarcotics, counterterrorism, and “train and equip.” The constellation of anti-government elements known collectively as the Taliban continues to refuse reconciliation or a negotiated peace under the existing Afghan constitution.https://press.armywarcollege.edu/monographs/1372/thumbnail.jp

An Unnatural Partnership? The Future of U.S.-India Strategic Cooperation

As global competition with an increasingly assertive Chinese Government expands, the strategic relationship between India and the United States is assuming ever-greater importance. From a superficial perspective, a strategic partnership seems to make a great deal of sense for both countries. Yet, enormous political, cultural, and structural obstacles remain between them, which continue to slow the progress in security cooperation to a crawl, relative to China’s economic and military advances. The authors explore these impediments frankly and suggest practical ways to build trust and establish confidence.https://press.armywarcollege.edu/monographs/1923/thumbnail.jp

Putting the ‘love back in’ to journalism: Transforming habitus in Aboriginal affairs student reporting

While journalism scholars have identified a lack of critical reflexivity in journalism, few have identified ways to educate university students for critically reflexive journalism practice. This article reports on a university teaching project that enables such practice as a means to counter exclusions, stereotyping and misrepresentation of Aboriginal people by large-scale Australian media. Using Bourdieu’s concept of habitus to track transformations in student dispositions, particularly as they relate to practice, the article shows how participating students became more competent and confident Aboriginal affairs journalists with a strengthened sense of themselves, their practice and the journalistic field. Their investment in the field was strengthened as they sought to tell hidden and disregarded stories, and to include previously excluded voices, perspectives and representations. The article describes and analyses an example of critically reflexive learning, practice and teaching that has the potential to transform students’ learning, the journalistic field and relations between Aboriginal non-Aboriginal Australians

Why the where matters: A sense of place imperative for teaching better Indigenous affairs reporting

Much Indigenous affairs journalism in the Western Australian state capital of Perth reproduces colonial discourse and perpetuates racist stereotypes of Aboriginal people. Against this background the traditional custodians of Perth, the Noongar people, have struggled to find a media voice. Meanwhile, observers in several countries have critiqued a shift from journalism about specific places toward journalism concerned with no place in particular. Spurred by globalisation, this shift has de-emphasised the ‘where?’ question in the ‘what, where, who, why, how and when?’ template of journalistic investigation. Reporting from a project in which journalism students collaborated with Noongar community organisations, we argue that an understanding of Indigenous Australians’ profound connection to place can inform journalists about the underlying character of places about which they report. We suggest that working with Indigenous people can transform the way journalists conceptualise their careers, and help secure a sense of place for Indigenous people in the media. Finally, collaborating with Indigenous people can teach journalists to view their professional practices through a sense of place lens, re-emphasising the ‘where?’ question in its application to both geographic place and the realm of a journalist’s imagination

Japanese multinationals in the post-bubble era:new challenges and evolving capabilities

Since the bursting of Japan's bubble economy, from 1990 onwards, Japanese multinational companies (MNCs) have faced new competitive challenges and questions about the management practices on which they had built their initial success in global markets. Japanese engagement in the international economy has undergone a number of phases. In the period before the Second World War, Japanese companies learnt from foreign MNCs in trading, shipping, and manufacturing, frequently through strategic alliances, and leveraged their capabilities to succeed in overseas and largely Asian markets. In the immediate post-war decades, during the Japanese ‘economic miracle’, there were notable examples of MNC investment in raw materials and labour intensive production, but both inward and outward foreign direct investment were not significant. Japanese companies achieved leadership in management and technology, in order to support a strategy of export-orientated industrialization. Changes in government policies in the developed economies of the US and Western Europe forced leading Japanese manufacturers to convert themselves into MNCs and to transfer their home-grown capabilities to overseas subsidiaries. The period after 1990 marked declining Japanese competitiveness and it asked questions about the ability of Japanese MNCs to be more responsive and global in their strategies, organization and capabilities.No Full Tex

Part 1: Defining unproven cellular therapies

Given the potential of cell-based products, including stem/progenitor cells and immune cells, there is a global effort to introduce these therapies into the clinic to correct organ dysfunctions, to treat cancer and to abrogate autoimmune diseases and a wide variety of pathological conditions [1–3]. Relatively easy access to these cells, obtained from marrow, adipose, cord blood and other human tissues, provides tremendous opportunity for translational research, particularly for indications with no satisfactory medical solution for patients with “unmet medical needs.” Prenatal and adult stem cells (including induced pluripotent stem cells have significant potential to rebuild tissues and correct dysfunctional organs in human diseases

Faecal and urine metabolites, but not gut microbiota, may predict response to low FODMAP diet in irritable bowel syndrome

BackgroundThe low FODMAP diet (LFD) leads to clinical response in 50%-80% of patients with irritable bowel syndrome (IBS). It is unclear why only some patients respond.AimsTo determine if differences in baseline faecal microbiota or faecal and urine metabolite profiles may separate clinical responders to the diet from non-responders allowing predictive algorithms to be proposed.MethodsWe recruited adults fulfilling Rome III criteria for IBS to a blinded randomised controlled trial. Patients were randomised to sham diet with a placebo supplement (control) or LFD supplemented with either placebo (LFD) or 1.8 g/d B-galactooligosaccharide (LFD/B-GOS), for 4 weeks. Clinical response was defined as adequate symptom relief at 4 weeks after the intervention (global symptom question). Differences between responders and non-responders in faecal microbiota (FISH, 16S rRNA sequencing) and faecal (gas-liquid chromatography, gas-chromatography mass-spectrometry) and urine (1 H NMR) metabolites were analysed.ResultsAt 4 weeks, clinical response differed across the 3groups with adequate symptom relief of 30% (7/23) in controls, 50% (11/22) in the LFD group and 67% (16/24) in the LFD/B-GOS group (p = 0.048). In the control and the LFD/B-GOS groups, microbiota and metabolites did not separate responders from non-responders. In the LFD group, higher baseline faecal propionate (sensitivity 91%, specificity 89%) and cyclohexanecarboxylic acid esters (sensitivity 80%, specificity 78%), and urine metabolite profile (Q2 0.296 vs. randomised -0.175) predicted clinical response.ConclusionsBaseline faecal and urine metabolites may predict response to the LFD

Expression capable library for studies of Neisseria gonorrhoeae, version 1.0

Background The sexually transmitted disease, gonorrhea, is a serious health problem in developed as well as in developing countries, for which treatment continues to be a challenge. The recent completion of the genome sequence of the causative agent, Neisseria gonorrhoeae, opens up an entirely new set of approaches for studying this organism and the diseases it causes. Here, we describe the initial phases of the construction of an expression-capable clone set representing the protein-coding ORFs of the gonococcal genome using a recombination-based cloning system. Results The clone set thus far includes 1672 of the 2250 predicted ORFs of the N. gonorrhoeae genome, of which 1393 (83%) are sequence-validated. Included in this set are 48 of the 61 ORFs of the gonococcal genetic island of strain MS11, not present in the sequenced genome of strain FA1090. L-arabinose-inducible glutathione-S-transferase (GST)-fusions were constructed from random clones and each was shown to express a fusion protein of the predicted size following induction, demonstrating the use of the recombination cloning system. PCR amplicons of each ORF used in the cloning reactions were spotted onto glass slides to produce DNA microarrays representing 2035 genes of the gonococcal genome. Pilot experiments indicate that these arrays are suitable for the analysis of global gene expression in gonococci. Conclusion This archived set of Gateway® entry clones will facilitate high-throughput genomic and proteomic studies of gonococcal genes using a variety of expression and analysis systems. In addition, the DNA arrays produced will allow us to generate gene expression profiles of gonococci grown in a wide variety of conditions. Together, the resources produced in this work will facilitate experiments to dissect the molecular mechanisms of gonococcal pathogenesis on a global scale, and ultimately lead to the determination of the functions of unknown genes in the genome