2,802 research outputs found

    Cloning of polyadenylated ribonucleic acid sequences from Drosophila

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    Vortex Glass is a Metal: Unified Theory of the Magnetic Field and Disorder-Tuned Bose Metals

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    We consider the disordered quantum rotor model in the presence of a magnetic field. We analyze the transport properties in the vicinity of the multicritical point between the superconductor, phase glass and paramagnetic phases. We find that the magnetic field leaves metallic transport of bosons in the glassy phase in tact. In the vicinity of the vicinity of the superconductivity-to-Bose metal transition, the resistitivy turns on as (HHc)2(H-H_c)^{2} with HcH_c. This functional form is in excellent agreement with the experimentally observed turn-on of the resistivity in the metallic state in MoGe, namely RRc(HHc)μR\approx R_c(H-H_c)^\mu, 1<μ<31<\mu<3. The metallic state is also shown to presist in three spatial dimensions. In addition, we also show that the metallic state remains intact in the presence of Ohmic dissipation in spite of recent claims to the contrary. As the phase glass in d=3d=3 is identical to the vortex glass, we conclude that the vortex glass is, in actuality, a metal rather than a superconductor at T=0. Our analysis unifies the recent experiments on vortex glass systems in which the linear resistivity remained non-zero below the putative vortex glass transition and the experiments on thin films in which a metallic phase has been observed to disrupt the direct transition from a superconductor to an insulator.Comment: Published version with an appendix showing that the claim in cond-mat/0510380 (and cond-mat/0606522) that Ohmic dissipation in the phase glass leads to a superconducting state is false. A metal persists in this case as wel

    Dyskerin, telomerase and the DNA damage response

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    Equilibrium extraction characteristics of alkyl amines and nuclear fuel metals in nitrate systems: progress report for the period January 1 - September 31 [sic], 1963 : progress report XII

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    "December 2, 1963."Includes bibliographical references (pages 29-30)Progress report no. XII; January 1, 1963 - September 30, 1963Work performed under subcontract no. 1327 under contract no. W -7405 - Eng - 26 with Union Carbide Nuclear Corporation Oak Ridge, Tennesse

    Equilibrium extraction characteristics of alkyl amines and nuclear fuel metals in nitrate systems: progress report for the period October 1 - May 30, 1964 : progress report XIII

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    "August 3, 1964."Includes bibliographical references (page 32)Progress report no. XIII; October 1, 1963 - May 30, 1964Work performed under subcontract no. 1327 under contract no. W -7405 - Eng - 26 with Union Carbide Nuclear Corporation Oak Ridge, Tennesse

    Improving prostate cancer detection in veterans through the development of a clinical decision rule for prostate biopsy

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    BACKGROUND: We sought to improve prostate cancer (PC) detection through developing a prostate biopsy clinical decision rule (PBCDR), based on an elevated PSA and laboratory biomarkers. This decision rule could be used after initial PC screening, providing the patient and clinician information to consider prior to biopsy. METHODS: This case–control study evaluated men from the Tampa, Florida, James A. Haley (JH) Veteran’s Administration (VA) (N = 1,378), from January 1, 1998, through April 15, 2005. To assess the PBCDR we did all of the following: 1) Identified biomarkers that are related to PC and have the capability of improving the efficiency of PC screening; 2) Developed statistical models to determine which can best predict the probability of PC; 3) Compared each potential model to PSA alone using Receiver Operator Characteristic (ROC) curves, to evaluate for improved overall effectiveness in PC detection and reduction in (negative) biopsies; and 4) Evaluated dose–response relationships between specified lab biomarkers (surrogates for extra-prostatic disease development) and PC progression. RESULTS: The following biomarkers were related to PC: hemoglobin (HGB) (OR = 1.42 95% CI 1.27, 1.59); red blood cell (RBC) count (OR = 2.52 95% CI 1.67, 3.78); PSA (OR = 1.04 95% CI 1.03, 1.05); and, creatinine (OR = 1.55 95% CI 1.12, 2.15). Comparing all PC stages versus non-cancerous conditions, the ROC curve area under the curve (AUC) enlarged (increasing the probability of correctly classifying PC): PSA (alone) 0.59 (95% CI 0.55, 0.61); PBCDR model 0.68 (95% CI 0.65, 0.71), and the positive predictive value (PPV) increased: PSA 44.7%; PBCDR model 61.8%. Comparing PC (stages II, III, IV) vs. other, the ROC AUC increased: PSA (alone) 0.63 (95% CI 0.58, 0.66); PBCDR model 0.72 (95% CI 0.68, 0.75), and the PPV increased: 20.6% (PSA); PBCDR model 55.3%. CONCLUSIONS: These results suggest evaluating certain common biomarkers in conjunction with PSA may improve PC prediction prior to biopsy. Moreover, these biomarkers may be more helpful in detecting clinically relevant PC. Follow-up studies should begin with replicating the study on different U.S. VA patients involving multiple practices

    High-throughput Saccharification Assay for Lignocellulosic Materials

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    Polysaccharides that make up plant lignocellulosic biomass can be broken down to produce a range of sugars that subsequently can be used in establishing a biorefinery. These raw materials would constitute a new industrial platform, which is both sustainable and carbon neutral, to replace the current dependency on fossil fuel. The recalcitrance to deconstruction observed in lignocellulosic materials is produced by several intrinsic properties of plant cell walls. Crystalline cellulose is embedded in matrix polysaccharides such as xylans and arabinoxylans, and the whole structure is encased by the phenolic polymer lignin, that is also difficult to digest 1. In order to improve the digestibility of plant materials we need to discover the main bottlenecks for the saccharification of cell walls and also screen mutant and breeding populations to evaluate the variability in saccharification 2. These tasks require a high throughput approach and here we present an analytical platform that can perform saccharification analysis in a 96-well plate format. This platform has been developed to allow the screening of lignocellulose digestibility of large populations from varied plant species. We have scaled down the reaction volumes for gentle pretreatment, partial enzymatic hydrolysis and sugar determination, to allow large numbers to be assessed rapidly in an automated system

    Correcting the z~8 Galaxy Luminosity Function for Gravitational Lensing Magnification Bias

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    We present a Bayesian framework to account for the magnification bias from both strong and weak gravitational lensing in estimates of high-redshift galaxy luminosity functions. We illustrate our method by estimating the z8z\sim8 UV luminosity function using a sample of 97 Y-band dropouts (Lyman break galaxies) found in the Brightest of Reionizing Galaxies (BoRG) survey and from the literature. We find the luminosity function is well described by a Schechter function with characteristic magnitude of M=19.850.35+0.30M^\star = -19.85^{+0.30}_{-0.35}, faint-end slope of α=1.720.29+0.30\alpha = -1.72^{+0.30}_{-0.29}, and number density of log10Ψ[Mpc3]=3.000.31+0.23\log_{10} \Psi^\star [\textrm{Mpc}^{-3}] = -3.00^{+0.23}_{-0.31}. These parameters are consistent within the uncertainties with those inferred from the same sample without accounting for the magnification bias, demonstrating that the effect is small for current surveys at z8z\sim8, and cannot account for the apparent overdensity of bright galaxies compared to a Schechter function found recently by Bowler et al. (2014a,b) and Finkelstein et al. (2014). We estimate that the probability of finding a strongly lensed z8z\sim8 source in our sample is in the range 315%\sim 3-15 \% depending on limiting magnitude. We identify one strongly-lensed candidate and three cases of intermediate lensing in BoRG (estimated magnification μ>1.4\mu>1.4) in addition to the previously known candidate group-scale strong lens. Using a range of theoretical luminosity functions we conclude that magnification bias will dominate wide field surveys -- such as those planned for the Euclid and WFIRST missions -- especially at z>10z>10. Magnification bias will need to be accounted for in order to derive accurate estimates of high-redshift luminosity functions in these surveys and to distinguish between galaxy formation models.Comment: Accepted for publication in ApJ. 20 pages, 13 figure
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