Лечение мигрени в общей врачебной практике

Migraine is a rather common disorder in general practice. The article discusses the problems of pathogenesis and diagnosis of migraine, including the severe forms of the disease and its' different masks. The paper contains the data on the current approach to curing acute attacks and preventive treatment of migraine in general practice.Мигрень является довольно распространенным заболеванием в общей врачебной практике. В статье обсуждаются проблемы патогенеза и диагностики мигрени, в том числе ее тяжелых форм и масок. Кроме того, приводятся данные о современных подходах к лечению острых приступов мигрени и профилактики их развития

Налоговое бюджетирование как элемент системы налогового планирования перерабатывающих организаций АПК России

The economic activity of the processing organizations of the agro-industrial complex of Russia should be timely adapted to the volatile business conditions and promptly respond to changes in the external tax environment. In this regard, methods of tax planning are especially important, the use of which creates the conditions for ensuring the tax solvency of business entities. However, an assessment of the current state of tax management of organizations of the agro-industrial complex of Russia, including sugar production in the Voronezh region, indicates some shortcomings of the latter. The purpose of article is the theoretical justification and methodological support of tools for improving the internal tax environment of processing organizations in the form of tax budgeting. For this, the forms and contents of two tax budgets are offered - all tax liabilities and income tax in relation to sugar production organizations. Using these tools will increase the tax solvency of processing organizations of Agro-industrial complex.Экономическая деятельность перерабатывающих организаций АПК России должна своевременно адаптироваться к волатильным условиям хозяйствования и оперативно реагировать на изменения во внешней налоговой среде. В связи с этим особую значимость приобретают приемы и способы налогового планирования, использование которых создает условия для обеспечения налоговой состоятельности субъектов хозяйствования. Однако оценка современного состояния налогового менеджмента организаций АПК России, в том числе сахарного производства Воронежской области, свидетельствует о некоторых недостатках последнего. Цель данной статьи заключается в теоретическом обосновании и методическом обеспечении инструментов совершенствования внутренней налоговой среды перерабатывающих организаций в виде налогового бюджетирования. Для этого разработаны формы и содержание двух налоговых бюджетов – всех налоговых обязательств и налога на прибыль применительно к организациям сахарного производства. Использование данных инструментов позволит повысить налоговую состоятельность перерабатывающих организаций АПК

Charge and spin configurations in the coupled quantum dots with Coulomb correlations induced by tunneling current

We investigated the peculiarities of non-equilibrium charge states and spin configurations in the system of two strongly coupled quantum dots (QDs) weakly connected to the electrodes in the presence of Coulomb correlations. We analyzed the modification of non-equilibrium charge states and different spin configurations of the system in a wide range of applied bias voltage and revealed well pronounced ranges of system parameters where negative tunneling conductivity appears due to the Coulomb correlations.Comment: 10 pages, 6 figure

Feasibility studies for the measurement of time-like proton electromagnetic form factors from p¯ p→ μ+μ- at P ¯ ANDA at FAIR

This paper reports on Monte Carlo simulation results for future measurements of the moduli of time-like proton electromagnetic form factors, | GE| and | GM| , using the p¯ p→ μ+μ- reaction at P ¯ ANDA (FAIR). The electromagnetic form factors are fundamental quantities parameterizing the electric and magnetic structure of hadrons. This work estimates the statistical and total accuracy with which the form factors can be measured at P ¯ ANDA , using an analysis of simulated data within the PandaRoot software framework. The most crucial background channel is p¯ p→ π+π-, due to the very similar behavior of muons and pions in the detector. The suppression factors are evaluated for this and all other relevant background channels at different values of antiproton beam momentum. The signal/background separation is based on a multivariate analysis, using the Boosted Decision Trees method. An expected background subtraction is included in this study, based on realistic angular distributions of the background contribution. Systematic uncertainties are considered and the relative total uncertainties of the form factor measurements are presented

ACETAZOLAMIDE IS A MEDICINE FOR THE MEDICATED CORRECTION OF THE SLEEP APNEA AND HYPOPNEA SYNDROME AMONG CHILDREN AND ADULTS

Sleep apnea and hypopnea syndrome is a life bendangering sleep dis order among both adults and children. The prevalence of the sleep apnea and hypopnea syndrome both in adult and pediatric population may be evaluated only approximately, as not all of the patients, suffering from this pathology, may call some adequate complaints, which, in their turn, help diagnose the disease. For example, only obstructive sleep apnea syndrome according to the data of British epidemiologists is met among the adults at the frequency rate, which can be compared with the prevalence of the bronchial asthma. Since metabolic acidosis caused by the carbonic anhydrase inhibitor of acetazolamide stimulates the ventilation of lungs, the researchers have set forth a supposition that the application of this medicine can be efficient to treat the respiratory disturbances in sleep. There is wide application of acetazolamide for the medicated correction of sleep apnea and hypopnea syndrome of the central genesis among both adults and children. When using acetazolamide for the long term therapy of respiratory disturbances among adult patients, the main issue is the probable growth of tolerance towards the carbonic anhydrase inhibitor along with the continuous longbterm application of the medicine. In pediatry, quite on the contrary, the sleep apnea and hypopnea syndrome is usually a transit problem of the early infancy and it does not require any longbterm drug therapy, which defines specifically high perspectives of the efficient and safe application of acetazolamide for the medicated correction of respiratory disturbances in sleep precisely within this category of patients.Key words: apnea, hypopnea, sleep disorder, acetazolamide, children.</p

ACETAZOLAMIDE IN PEDIATRIC NEUROLOGY: HISTORY AND PERSPECTIVE OF CILNICAL USE

Resume the up tob date pharmacological and clinical findings have revealed new opportunities for the use of known for a long time pharmaceutical agents in various fields of practical medicine. For more than 50 years acetozolamide, systemic carbonic anhydrase inhibitor, has been used in neurology to correct liquorodynamic disorders. High clinical efficacy and good tolerb ability in longbterm use has made acetazolamide an essential agent in pediatric neurology, along with this the true therapeutic application of acetazolamide is much wider than it was traditionally thought. This review analyzes the experience of administration of the drug in different branches of pediatric neurology, including those where acetazolamide has been traditionally used along with novel applications to administration of the drug in children.Key words: acetozolamide, carboanhydrase, children, sleep apnea syndrome, glaucoma, hydrocephaly, episodic ataxia type II, migraine, intracranial idiopathic benign hemiplegic hypertension

INTERFERON BETA 1B FOR THE IMMUNOMODULATORY TREATMENT OF MULTIOCULAR SCLEROSIS IN PEDIATRIC NEUROLOGIC PRACTICES

Medications for the immunomodulatory therapy of the multiocular sclerosis are widely spread and have been applied in adult neurologic practices for a long time, although the data about their use among the patients under 18 is scarce and not classified. We present the history of foreign and russian experience in application of the medication for the immunomodulatory therapy of the multiocular sclerosis — interferon beta 1b — among children and teenagers along with the brief analysis of the acquired data about effectiveness and safety of this type of treatment in pediatrics in the published research.Key words: multiocular sclerosis, immunomodulatory therapy, children, teenagers

ИНТЕРФЕРОН БЕТА 1B ДЛЯ ИММУНОМОДУЛИРУЮЩЕГО ЛЕЧЕНИЯ РАССЕЯННОГО СКЛЕРОЗА В ПЕДИАТРИЧЕСКОЙ НЕВРОЛОГИЧЕСКОЙ ПРАКТИКЕ

Medications for the immunomodulatory therapy of the multiocular sclerosis are widely spread and have been applied in adult neurologic practices for a long time, although the data about their use among the patients under 18 is scarce and not classified. We present the history of foreign and russian experience in application of the medication for the immunomodulatory therapy of the multiocular sclerosis — interferon beta 1b — among children and teenagers along with the brief analysis of the acquired data about effectiveness and safety of this type of treatment in pediatrics in the published research.Key words: multiocular sclerosis, immunomodulatory therapy, children, teenagers.Препараты для иммуномодулирующей терапии рассеянного склероза широко распространены и давно применяются во взрослой неврологической практике, однако данные об их использовании у больных до 18 лет немногочисленны и не систематизированы. Мы представляем вашему вниманию историю зарубежного и отечественного опыта применения препарата для иммуномодулирующей терапии рассеянного склероза интерферона бета 1b у детей и подростков, с кратким анализом полученных в опубликованных исследованиях данных об эффективности и безопасности этого вида лечения в педиатрии. Ключевые слова: рассеянный склероз, иммуномодулирующая терапия, дети, подростки.(Педиатрическая фармакология. – 2006;3(6):35-38