On compressive radial tidal forces

Radial tidal forces can be compressive instead of disruptive, a possibility that is frequently overlooked in high level physics courses. For example, radial tidal compression can emerge in extended stellar systems containing a smaller stellar cluster. For particular conditions the tidal field produced by this extended mass distribution can exert on the cluster it contains compressive effects instead of the common disruptive forces. This interesting aspect of gravity can be derived from standard relations given in many textbooks and introductory courses in astronomy and can serve as an opportunity to look closer at some aspects of gravitational physics, stellar dynamics, and differential geometry. The existence of compressive tides at the center of huge stellar systems might suggest new evolutionary scenarios for the formation of stars and primordial galactic formation processes.Comment: 22 pages, 2 figure

Cultural Heritage and natural disasters: the insurance choice of the Italian Cathedrals

Given the threat of natural disasters to Cultural Heritage, this paper aims to investigate how the use of the insurance instrument contributes to the definition of an adequate risk management strategy. The analysis focuses on the role that insurance can play both by supplying policies covering damage and proactively stimulating prevention behaviors, taking into consideration information imperfections (i.e., adverse selection, moral hazard and charity hazard). Through a survey among Italian Dioceses, data about the diffusion of insurance contracts were collected together with other qualitative and quantitative elements linked to the decisional process of insuring Italian Cathedrals. The empirical analysis shows that the administrators of the Dioceses are aware of the economic value of the cultural assets and in safeguarding the Cathedrals they identify in the insurance system a useful and efficient risk management instrument

The effects of the initial mass function on the chemical evolution of elliptical galaxies

We describe the use of our chemical evolution model to reproduce the abundance patterns observed in a catalogue of elliptical galaxies from the Sloan Digital Sky Survey Data Release 4. The model assumes ellipticals form by fast gas accretion, and suffer a strong burst of star formation followed by a galactic wind, which quenches star formation. Models with fixed initial mass function (IMF) failed in simultaneously reproducing the observed trends with the galactic mass. So, we tested a varying IMF; contrary to the diffused claim that the IMF should become bottom heavier in more massive galaxies, we find a better agreement with data by assuming an inverse trend, where the IMF goes from being bottom heavy in less massive galaxies to top heavy in more massive ones. This naturally produces a downsizing in star formation, favouring massive stars in largest galaxies. Finally, we tested the use of the integrated Galactic IMF, obtained by averaging the canonical IMF over the mass distribution function of the clusters where star formation is assumed to take place. We combined two prescriptions, valid for different SFR regimes, to obtain the Integrated Initial Mass Function values along the whole evolution of the galaxies in our models. Predicted abundance trends reproduce the observed slopes, but they have an offset relative to the data. We conclude that bottom-heavier IMFs do not reproduce the properties of the most massive ellipticals, at variance with previous suggestions. On the other hand, an IMF varying with galactic mass from bottom heavier to top heavier should be preferred

Optical mapping of neuronal activity during seizures in zebrafish

Mapping neuronal activity during the onset and propagation of epileptic seizures can provide a better understanding of the mechanisms underlying this pathology and improve our approaches to the development of new drugs. Recently, zebrafish has become an important model for studying epilepsy both in basic research and in drug discovery. Here, we employed a transgenic line with pan-neuronal expression of the genetically-encoded calcium indicator GCaMP6s to measure neuronal activity in zebrafish larvae during seizures induced by pentylenetretrazole (PTZ). With this approach, we mapped neuronal activity in different areas of the larval brain, demonstrating the high sensitivity of this method to different levels of alteration, as induced by increasing PTZ concentrations, and the rescuing effect of an anti-epileptic drug. We also present simultaneous measurements of brain and locomotor activity, as well as a high-throughput assay, demonstrating that GCaMP measurements can complement behavioural assays for the detection of subclinical epileptic seizures, thus enabling future investigations on human hypomorphic mutations and more effective drug screening methods. Notably, the methodology described here can be easily applied to the study of many human neuropathologies modelled in zebrafish, allowing a simple and yet detailed investigation of brain activity alterations associated with the pathological phenotype

<b><i>Topoisomerase 1</i></b> Promoter Variants and Benefit from Irinotecan in Metastatic Colorectal Cancer Patients

Objective: Topoisomerase 1 (topo-1) is an important target for the treatment of metastatic colorectal cancer (CRC). The aim of the present study was to evaluate the correlation between topo-1 single-nucleotide polymorphisms (SNPs) and clinical outcome in metastatic CRC (mCRC) patients. Methods: With the use of specific software (PROMO 3.0), we performed an in silico analysis of topo-1 promoter SNPs; the rs6072249 and rs34282819 SNPs were included in the study. DNA was extracted from 105 mCRC patients treated with FOLFIRI ± bevacizumab in the first line. SNP genotyping was performed by real-time PCR. Genotypes were correlated with clinical parameters (objective response rate, progression-free survival, and overall survival). Results: No single genotype was significantly associated with clinical variables. The G allelic variant of rs6072249 topo-1 SNP is responsible for GC factor and X-box-binding protein transcription factor binding. The same allelic variant showed a nonsignificant trend toward a shorter progression-free survival (GG, 7.5 months; other genotypes, 9.3 months; HR 1.823, 95% CI 0.8904-3.734; p = 0.1). Conclusion: Further analyses are needed to confirm that the topo-1 SNP rs6072249 and transcription factor interaction could be a part of tools to predict clinical outcome in mCRC patients treated with irinotecan-based regimens

Multi-mode TES bolometer optimization for the LSPE-SWIPE instrument

In this paper we explore the possibility of using transition edge sensor (TES) detectors in multi-mode configuration in the focal plane of the Short Wavelength Instrument for the Polarization Explorer (SWIPE) of the balloon-borne polarimeter Large Scale Polarization Explorer (LSPE) for the Cosmic Microwave Background (CMB) polarization. This study is motivated by the fact that maximizing the sensitivity of TES bolometers, under the augmented background due to the multi-mode design, requires a non trivial choice of detector parameters. We evaluate the best parameter combination taking into account scanning strategy, noise constraints, saturation power and operating temperature of the cryostat during the flight.Comment: in Journal of Low Temperature Physics, 05 January 201