A comparative study of peroxisomal structures in Hansenula polymorpha pex mutants

In a recent study, we performed a systematic genome analysis for the conservation of genes involved in peroxisome biogenesis (PEX genes) in various fungi. We have now performed a systematic study of the morphology of peroxisome remnants (‘ghosts’) in Hansenula polymorpha pex mutants (pex1–pex20) and the level of peroxins and matrix proteins in these strains. To this end, all available H. polymorpha pex strains were grown under identical cultivation conditions in glucose-limited chemostat cultures and analyzed in detail. The H. polymorpha pex mutants could be categorized into four distinct groups, namely pex mutants containing: (1) virtually normal peroxisomal structures (pex7, pex17, pex20); (2) small peroxisomal membrane structures with a distinct lumen (pex2, pex4, pex5, pex10, pex12, pex14); (3) multilayered membrane structures lacking apparent matrix protein content (pex1, pex6, pex8, pex13); and (4) no peroxisomal structures (pex3, pex19).

Observation of Toroidal Flow on LHD

In order to investigate the formation of toroidal flow in helical systems, both NBI driven flow and spontaneous toroidal flow were observed in Large Helical Device (LHD). The toroidal flow driven by NBI is dominant in plasma core while its contribution is small near plasma edge. The spontaneous toroidal flow changes its direction from co to counter when the radial electric field is changed from negative to positive at plasma edge. The direction of the spontaneous toroidal flow due to the radial electric field near plasma edge is observed to be opposite to that in plasma core where the helical ripple is small

Microlensing Results Challenge the Core Accretion Runaway Growth Scenario for Gas Giants

We compare the planet-to-star mass-ratio distribution measured by gravitational microlensing to core accretion theory predictions from population synthesis models. The core accretion theory's runaway gas accretion process predicts a dearth of intermediate-mass giant planets that is not seen in the microlensing results. In particular, the models predict $\sim10\,\times$ fewer planets at mass ratios of $10^{-4} \leq q \leq 4 \times 10^{-4}$ than inferred from microlensing observations. This tension implies that gas giant formation may involve processes that have hitherto been overlooked by existing core accretion models or that the planet-forming environment varies considerably as a function of host-star mass. Variation from the usual assumptions for the protoplanetary disk viscosity and thickness could reduce this discrepancy, but such changes might conflict with microlensing results at larger or smaller mass ratios, or with other observations. The resolution of this discrepancy may have important implications for planetary habitability because it has been suggested that the runaway gas accretion process may have triggered the delivery of water to our inner solar system. So, an understanding of giant planet formation may help us to determine the occurrence rate of habitable planets.Comment: 12 pages, 2 figures, 1 table, accepted for publication in ApJ

Improvement of Automatic Physics Data Analysis Environment for the LHD Experiment

The physical data of the Large Helical Device (LHD) project have been serviced by the Analyzed Data Server system, and approximately 600 kinds of physical data are served. In order to execute simulation programs for the LHD experiment, one must gather sets of physical data. Because the Automatic Analyzed Server (AutoAna) calculates the physical data automatically, it eases the scientist’s task of collecting these physical data. The AutoAna has provided better computing environments for the scientists. Thus, the scientists, having recognized its benefits, make various requests as issues arise. In this paper, the authors introduce the current status of the AutoAna system

Revisiting Metchnikoff: Age-related alterations in microbiota-gut-brain axis in the mouse

Over the last decade, there has been increased interest in the role of the gut microbiome in health including brain health. This is by no means a new theory; Elie Metchnikoff proposed over a century ago that targeting the gut by consuming lactic acid bacteria such as those in yogurt, could improve or delay the onset of cognitive decline associated with ageing. However, there is limited information characterising the relationship between the behavioural and physiological sequelae of ageing and alterations in the gut microbiome. To this end, we assessed the behavioural, physiological and caecal microbiota profile of aged male mice. Older mice (20–21 months old) exhibited deficits in spatial memory and increases in anxiety-like behaviours compared to younger mice (2–3 months old). They also exhibited increased gut permeability, which was directly correlated with elevations in peripheral pro-inflammatory cytokines. Furthermore, stress exacerbated the gut permeability of aged mice. Examination of the caecal microbiota revealed significant increases in phylum TM7, family Porphyromonadaceae and genus Odoribacter of aged mice. This represents a shift of aged microbiota towards a profile previously associated with inflammatory disease, particularly gastrointestinal and liver disorders. Furthermore, Porphyromonadaceae, which has also been associated with cognitive decline and affective disorders, was directly correlated with anxiety-like behaviour in aged mice. These changes suggest that changes in the gut microbiota and associated increases in gut permeability and peripheral inflammation may be important mediators of the impairments in behavioural, affective and cognitive functions seen in ageing

Definition of the profile gain factor and its application for internal transport barrier analysis in torus plasmas

In this paper, a new criterion for the internal transport barrier (ITB) formation is proposed by defining a unique scalar parameter, the profile gain factor. The profile gain factor shows degree of the confinement improvement with respect to an arbitrary reference temperature profile in the L-mode. As the reference L-mode profile for the large helical device (LHD), the edge ion temperature profile data is extrapolated to the core by the L-mode profile function, which is characterized by the thermal diffusion coefficient being proportional to the local ion temperature. The profile gain factor is defined as the ratio of the ion stored energy experimentally measured to that evaluated from the reference L-mode profile. The proposed method is applied to the LHD experimental data, and its capability for quantification of the ITB strength is demonstrated

The Effect of Non-Axisymmetry of Magnetic Configurations on Radial Electric Field Transition Properties in the LHD

Transition property of the radial electric field (Er) in LHD have been theoretically investigated and also applied to explain experimental results. Especially, effects of the helicity of the magnetic configuration on the condition to realize the electron root are examined. Larger helicity makes the threshold collisionality higher. This is attributed to the nonlinear dependence of Γe(Er) in a low collisional regime. This interesting feature predicts that the threshold temperature becomes higher for a case of smaller helicity. The variation of the threshold density anticipated from the analysis for cases with different magnetic axis position is qualitatively verified in the density scan experiment

Search for Outer Massive Bodies around Transiting Planetary Systems: Candidates of Faint Stellar Companions around HAT-P-7

We present results of direct imaging observations for HAT-P-7 taken with the Subaru HiCIAO and the Calar Alto AstraLux. Since the close-in transiting planet HAT-P-7b was reported to have a highly tilted orbit, massive bodies such as giant planets, brown dwarfs, or a binary star are expected to exist in the outer region of this system. We show that there are indeed two candidates for distant faint stellar companions around HAT-P-7. We discuss possible roles played by such companions on the orbital evolution of HAT-P-7b. We conclude that as there is a third body in the system as reported by Winn et al. (2009, ApJL, 763, L99), the Kozai migration is less likely while planet-planet scattering is possible.Comment: 8 pages, 3 figures, 2 tables, PASJ in pres

High Baseline Lipoprotein(a) Level as a Risk Factor for Coronary Artery Calcification Progression: Sub-analysis of a Prospective Multicenter Trial

Lipoprotein(a), or Lp(a), is a low-density lipoprotein-like particle largely independent of known risk factors for, and predictive of, cardiovascular disease (CVD). We investigated the association between baseline Lp(a) levels and the progression of coronary artery calcification (CAC) in patients with hypercholesterolemia undergoing statin therapy. This study was a sub-analysis of a multicenter prospective study that evaluated the annual progression of CAC under intensive and standard pitavastatin treatment with or without eicosapentaenoic acid in patients with an Agatston score of 1 to 999, and hypercholesterolemia treated with statins. We classified the patients into 3 groups according to CAC progression. A total of 147 patients (mean age, 67 years; men, 54%) were analyzed. The proportion of patients with Lp(a) > 30 mg/dL significantly increased as CAC progressed (non-progression; 5.4%, 0100; 23.6%). Logistic regression analysis showed that Lp(a) > 30 mg/dL was an independent predictor of the annual change in Agatston score > 100 (OR: 5.51; 95% CI: 1.28-23.68; p=0.02), even after adjusting for age, sex, hypertension, diabetes mellitus, current smoking, body mass index, and lipid-lowering medications. Baseline Lp(a) >30 mg/dL was a predictor of CAC progression in this population of patients with hypercholesterolemia undergoing statin therapy