Non-Abelian Topological Order in S-Wave Superfluids of Ultracold Fermionic Atoms

We show that in s-wave superfluids of cold fermionic atoms with laser-field-generated effective spin-orbit interactions, a topological phase with gapless edge states and Majorana fermion quasiparticles obeying the non-Abelian statistics is realized in the case with a large Zeeman magnetic field. Our scenario provides a promising approach for quantum computation manipulating non-Abelian anyons via an s-wave Feshbach resonance.Comment: 5 pages, 2 figures. Some minor improvements were mad

Salvage brachytherapy for seminal vesicle recurrence after initial brachytherapy for prostate cancer: a case report

BACKGROUND: To report the efficacy and safety of salvage brachytherapy for seminal vesicle recurrence after initial brachytherapy in a patient with prostate cancer. As far as we know, this is a first report of salvage brachytherapy for seminal vesicle recurrence in Japan. CASE PRESENTATION: A 70-year-old Japanese man with low-risk prostate cancer received low-dose-rate brachytherapy. Forty-two months after the seed implantation, he showed biochemical recurrence based on the nadir + 2 ng/mL definition. The prostate specific antigen (PSA) level was 5.11 ng/mL at 58 months after seed implantation. A saturation biopsy of the prostate showed no recurrence. Systemic screening also showed no distant metastases. However, T2-weighted magnetic resonance imaging (MRI) demonstrated a low intensity area at the base of the right seminal vesicle, which was strongly suggestive of recurrence. Sixty months after the initial therapy, a seminal vesicle biopsy confirmed recurrence with a Gleason score of 4 + 3 before salvage brachytherapy was performed. The prescribed dose was 145 Gy, the same as the dose of the initial therapy. One month later, the PSA level had rapidly declined to 0.898 ng/mL without androgen deprivation therapy. Ten months after the salvage brachytherapy, the PSA level reached 0.078 ng/mL. No adverse events were seen during the follow-up period. CONCLUSIONS: We experienced a patient who was successfully treated with salvage brachytherapy for seminal vesicle recurrence. Salvage brachytherapy is one of the promising therapeutic options for recurrence after initial brachytherapy

Tespa1 is a novel inositol 1,4,5-trisphosphate receptor binding protein in T and B lymphocytes

AbstractTespa1 has been recently reported to be a critical molecule in T-cell development, however, the precise molecular mechanisms of Tespa1 remain elusive. Here, we demonstrate that Tespa1 shows amino-acid sequence homology to KRAS-induced actin-interacting protein (KRAP), an inositol 1,4,5-trisphosphate receptor (IP3R) binding protein, and that Tespa1 physically associates with IP3R in T and B lymphocytes. Two-consecutive phenylalanine residues (Phe185/Phe186) in Tespa1, which are conserved between Tespa1 and KRAP, are indispensable for the association between Tespa1 and IP3R. These findings suggest that Tespa1 plays critical roles in the immune system through the regulation of the IP3R

Subaru High-z Exploration of Low-Luminosity Quasars (SHELLQs) VIII. A less biased view of the early co-evolution of black holes and host galaxies

We present ALMA [CII] line and far-infrared (FIR) continuum observations of three $z > 6$ low-luminosity quasars ($M_{\rm 1450} > -25$) discovered by our Subaru Hyper Suprime-Cam (HSC) survey. The [CII] line was detected in all three targets with luminosities of $(2.4 - 9.5) \times 10^8~L_\odot$, about one order of magnitude smaller than optically luminous ($M_{\rm 1450} \lesssim -25$) quasars. The FIR continuum luminosities range from $< 9 \times 10^{10}~L_\odot$ (3$\sigma$ limit) to $\sim 2 \times 10^{12}~L_\odot$, indicating a wide range in star formation rates in these galaxies. Most of the HSC quasars studied thus far show [CII]/FIR luminosity ratios similar to local star-forming galaxies. Using the [CII]-based dynamical mass ($M_{\rm dyn}$) as a surrogate for bulge stellar mass ($M_{\rm bulge}$), we find that a significant fraction of low-luminosity quasars are located on or even below the local $M_{\rm BH} - M_{\rm bulge}$ relation, particularly at the massive end of the galaxy mass distribution. In contrast, previous studies of optically luminous quasars have found that black holes are overmassive relative to the local relation. Given the low luminosities of our targets, we are exploring the nature of the early co-evolution of supermassive black holes and their hosts in a less biased way. Almost all of the quasars presented in this work are growing their black hole mass at much higher pace at $z \sim 6$ than the parallel growth model, in which supermassive black holes and their hosts grow simultaneously to match the local $M_{\rm BH} - M_{\rm bulge}$ relation at all redshifts. As the low-luminosity quasars appear to realize the local co-evolutionary relation even at $z \sim 6$, they should have experienced vigorous starbursts prior to the currently observed quasar phase to catch up with the relation.Comment: 19 pages, 11 figures, 4 tables. Accepted for publication in Publications of the Astronomical Society of Japan (PASJ

Subaru High-z Exploration of Low-Luminosity Quasars (SHELLQs) III. Star formation properties of the host galaxies at z≳6z \gtrsim 6 studied with ALMA

We present our ALMA Cycle 4 measurements of the [CII] emission line and the underlying far-infrared (FIR) continuum emission from four optically low-luminosity ($M_{\rm 1450} > -25$) quasars at $z \gtrsim 6$ discovered by the Subaru Hyper Suprime Cam (HSC) survey. The [CII] line and FIR continuum luminosities lie in the ranges $L_{\rm [CII]} = (3.8-10.2) \times 10^8~L_\odot$ and $L_{\rm FIR} = (1.2-2.0) \times 10^{11}~L_\odot$, which are at least one order of magnitude smaller than those of optically-luminous quasars at $z \gtrsim 6$. We estimate the star formation rates (SFR) of our targets as $\simeq 23-40~M_\odot ~{\rm yr}^{-1}$. Their line and continuum-emitting regions are marginally resolved, and found to be comparable in size to those of optically luminous quasars, indicating that their SFR or likely gas mass surface densities (key controlling parameter of mass accretion) are accordingly different. The $L_{\rm [CII]}/L_{\rm FIR}$ ratios of the hosts, $\simeq (2.2-8.7) \times 10^{-3}$, are fully consistent with local star-forming galaxies. Using the [CII] dynamics, we derived their dynamical masses within a radius of 1.5-2.5 kpc as $\simeq (1.4-8.2) \times 10^{10}~M_\odot$. By interpreting these masses as stellar ones, we suggest that these faint quasar hosts are on or even below the star-forming main sequence at $z \sim 6$, i.e., they appear to be transforming into quiescent galaxies. This is in contrast to the optically luminous quasars at those redshifts, which show starburst-like properties. Finally, we find that the ratios of black hole mass to host galaxy dynamical mass of the most of low-luminosity quasars including the HSC ones are consistent with the local value. The mass ratios of the HSC quasars can be reproduced by a semi-analytical model that assumes merger-induced black hole-host galaxy evolution.Comment: 20 pages, 9 figures, 4 tables. Accepted for publication in PAS

Subaru High-z Exploration of Low-Luminosity Quasars (SHELLQs). XIV. A Candidate Type-II Quasar at z=6.1292

We present deep Keck/MOSFIRE near-infrared spectroscopy of a strong Lyman alpha emitting source at z=6.1292, HSC J142331.71-001809.1, which was discovered by the SHELLQS program from imaging data of the Subaru Hyper Suprime-Cam (HSC) survey. This source is one of five objects that show unresolved (10^44 erg s-1) Lyman alpha emission lines at absolute 1450 angstrom continuum magnitudes of M1450~-22 mag. Its rest-frame Lyman alpha equivalent width (EW) is 370+/-30 angstrom. In the 2 hour Keck/MOSFIRE spectrum in Y band, the high-ionization CIV 1548,1550 doublet emission line was clearly detected with FWHM =120+/-20 km s-1 and a total rest-frame EW of 37-5+6 angstrom. We also report the detection of weak continuum emission, and the tentative detection of OIII] 1661,1666 in the 4 hour J band spectrum. Judging from the UV magnitude, line widths, luminosities, and EWs of Lyman alpha and CIV, we suggest that this source is a reionization-era analog of classical type-II AGNs, although there is a possibility that it represents a new population of AGN/galaxy composite objects in the early universe. We compare the properties of J1423-0018 to intermediate-redshift type-II AGNs and CIV emitters seen in z=6-7 galaxy samples. Further observations of other metal emission lines in the rest-frame UV or optical, and X-ray follow-up observations of the z=6-7 narrow-line quasars are needed for more robust diagnostics and to determine their nature.Comment: 15 pages, 8 figures, accepted for publication in the Astrophysical Journa

SERENADE II: An ALMA Multi-Band Dust-Continuum Analysis of 28 Galaxies at 5<z<85<z<8 and the Physical Origin of the Dust Temperature Evolution

We present an analysis of ALMA multi-band dust-continuum observations for 28 spectroscopically-confirmed bright Lyman-break galaxies at $5<z<8$. Our sample consists of 11 galaxies at $z\sim6$ newly observed in our ALMA program, which substantially increases the number of $5<z<8$ galaxies with both rest-frame 88 and 158 $\mu{\rm m}$ continuum observations, allowing us to simultaneously measure the IR luminosity and dust temperature for a statistical sample of $z\gtrsim5$ galaxies for the first time. We derive the relationship between the UV slope ($\beta_{\rm UV}$) and infrared excess (IRX) for the $z\sim6$ galaxies, and find a shallower IRX-$\beta_{\rm UV}$ relation compared to the previous results at $z\sim2$--4. Based on the IRX-$\beta_{\rm UV}$ relation consistent with our results and the $\beta_{\rm UV}$-$M_{\rm UV}$ relation including fainter galaxies in the literature, we find a limited contribution of the dust-obscured star formation to the total SFR density, $\sim30\%$ at $z\sim6$. Our measurements of the dust temperature at $z\sim6-7$, $T_{\rm dust}=40.9_{-9.1}^{+10.0}\,{\rm K}$ on average, supports a gentle increase of $T_{\rm dust}$ from $z=0$ to $z\sim6$--7. Using an analytic model with parameters consistent with recent {\it{JWST}} results, we discuss that the observed redshift evolution of the dust temperature can be reproduced by an $\sim0.6\,{\rm dex}$ increase in the gas depletion timescale and $\sim0.4\,{\rm dex}$ decrease of the metallicity. The variety of $T_{\rm dust}$ observed at high redshifts can also be naturally explained by scatters around the star-formation main sequence and average mass-metallicity relation, including an extremely high dust temperature of $T_{\rm dust}>80\,{\rm K}$ observed in a galaxy at $z=8.3$.Comment: Submitted to Ap

Prognostic Impact of Genetic Polymorphism in Mineralocorticoid Receptor and Comorbidity With Hypertension in Androgen-Deprivation Therapy

Mineralocorticoid receptor (MR) signaling which is closely associated with hypertension plays important roles in resistance to antiandrogen therapy in prostate cancer. However, its impact on the prognosis in androgen-deprivation therapy (ADT) has not been elucidated. Then, we investigated the impact of genetic variation in MR and comorbidity with hypertension on the prognosis in ADT. This study included 182 Japanese patients with prostate cancer treated with ADT, whose comorbidity status with hypertension were available. The associations of MR polymorphism (rs5522) and comorbidity with hypertension with clinicopathological parameters as well as progression-free survival and overall survival were examined. Clinicopathological characteristics were comparable between genetic variation in MR. However, homozygous variant in MR was associated with shorter time to castration resistance (P = 0.014) and any-cause death (P = 0.024). In patients' background, presence of comorbidity with hypertension showed the trend with lower PSA level at diagnosis and lower biopsy Gleason score, as well as significant association with less incidence of N1. Comorbidity with hypertension was associated with longer time to castration resistance (P = 0.043) and any-cause death (P = 0.046), which was diminished on multivariate analysis including age, PSA level at diagnosis, biopsy Gleason score, clinical stage, and the modality of hormonal therapy. Genetic variation in MR (rs5522) and comorbidity with hypertension were significantly and potentially associated with prognosis when treated with ADT, respectively. This suggests that the individual intensity of MR signaling may be associated with resistance to ADT and a promising biomarker in ADT