Quinofuracins A–E, Produced by the Fungus <i>Staphylotrichum boninense</i> PF1444, Show p53-Dependent Growth Suppression

Quinofuracins A–E, novel anthraquinone derivatives containing β-d-galactofuranose that were isolated from the fungus <i>Staphylotrichum boninense</i> PF1444, induced p53-dependent cell death in human tumor cells. The structures of quinofuracins A–E, including absolute configurations, were elucidated by extensive spectroscopic analysis and chemical transformation studies. Quinofuracins were classified into three groups according to the aglycone moieties. 5′-Oxoaverantin was present in quinofuracins A–C, whereas averantin and versicolorin B were identified in quinofuracins D and E, respectively. These quinofuracins induced p53-dependent growth suppression in human glioblastoma LNZTA3 cells