Tenth-Order QED Contribution to the Electron g-2 and an Improved Value of the Fine Structure Constant

This paper presents the complete QED contribution to the electron g-2 up to the tenth order. With the help of the automatic code generator, we have evaluated all 12672 diagrams of the tenth-order diagrams and obtained 9.16 (58)(\alpha/\pi)^5. We have also improved the eighth-order contribution obtaining -1.9097(20)(\alpha/\pi)^4, which includes the mass-dependent contributions. These results lead to a_e(theory)=1 159 652 181.78 (77) \times 10^{-12}. The improved value of the fine-structure constant \alpha^{-1} = 137.035 999 174 (35) [0.25 ppb] is also derived from the theory and measurement of a_e.Comment: 4 pages, 2 figures. Some numbers are slightly change

Tenth-Order Lepton Anomalous Magnetic Moment -- Sixth-Order Vertices Containing Vacuum-Polarization Subdiagrams

This paper reports the values of contributions to the electron g-2 from 300 Feynman diagrams of the gauge-invariant Set III(a) and 450 Feynman diagrams of the gauge-invariant Set III(b). The evaluation is carried out in two versions. Version A is to start from the sixth-order magnetic anomaly M_6 obtained in the previous work. The mass-independent contributions of Set III(a) and Set III(b) are 2.1275 (2) and 3.3271 (6) in units of (alpha/pi)^5, respectively. Version B is based on the recently-developed automatic code generation scheme. This method yields 2.1271 (3) and 3.3271 (8) in units of (alpha/pi)^5, respectively. They are in excellent agreement with the results of the first method within the uncertainties of numerical integration. Combining these results as statistically independent we obtain the best values, 2.1273 (2), and 3.3271 (5) times (alpha/pi)^5, for the mass-independent contributions of the Set III(a) and Set III(b), respectively. We have also evaluated mass-dependent contributions of diagrams containing muon and/or tau-particle loop. Including them the total contribution of Set III(a) is 2.1349 (2) and that of Set III(b) is 3.3299 (5) in units of (alpha/pi)^5. The total contributions to the muon g-2 of various leptonic vacuum-polarization loops of Set III(a) and Set III(b) are 112.418 (32) and 15.407 (5) in units of (alpha/pi)^5, respectively.Comment: 31 pages, 4 figure

Child-rearing Support with Collaboration between Municipalities and Hiroshima Universities: A Parent and Child Classroom to Support the Development of Language

本稿は、広島大学「地（知）の拠点大学による地方創生推進事業（大学COC 事業）」障がい者支援領域における、未就園児を対象とした子育て支援活動「のびのびくらぶ」の実施報告である。本活動は自治体と連携し、１歳半健康診査で「要経過観察」と判断された幼児とその保護者を対象としている。平成28年度は、計16回の活動を実施した。参加親子は各期５組、計10組20名であった。活動の企画・運営には本学学生ボランティア17名が参加した。参加した保護者10名のうち８名が「ことばの発達」に不安を抱いていると事前調査で回答していた。そのため、活動に絵本の読みあいを取り入れ、学生と参加児で自由に読みあうことを試みた。自治体との連携は、各期開始前後の打ち合わせ、毎回の活動後の振り返りおよび学生へのフィードバック、自治体主催の親子クラブへの学生参加、年度終わりの総括会議などを行った。This paper is a report of FY 2016 implementation of child rearing support activities for prekindergarden children in Hiroshima University“ Program for Promoting Regional Revitalization by Universities as Centers of Community : COC”. This activity cooperates with municipalities and covers infants and their guardians who have been judged to be “required follow-up observation” in medical examination for 1 year and a half. This activity is in collaboration with local governments, and infants and their parents who are judged to be “required follow-up” in health examination for 1 and half years are participating. In FY 2016, a total of 16 activities were conducted. Participating parents and children were 5 pairs in each period, totaling 10 pairs of 20 people. 17 student volunteers from our university participated in the planning and operation of activities. In the preliminary survey, eight of the 10 parents who participated answered that they were concerned about “children’s development”. For that reason, we took reading of the activity picture book and tried reading freely with students and children participating. Collaboration with municipalities was conducted before and after each activity, each activity was handed over to the students, and feedback was given to the students. Students also participated in parent-child clubs sponsored by municipalities and held general meetings at the end of the year

犬モデルにおける ex vivo および in vivo 遺伝子治療のための代替遺伝子導入技術の開発

Introduction: Gene therapy have recently attracted much attention as a curative therapeutic option for inherited single gene disorders such as hemophilia. Hemophilia is a hereditary bleeding disorder caused by the deficiency of clotting activity of factor VIII (FVIII) or factor IX (FIX), and gene therapy for hemophilia using viral vector have been vigorously investigated worldwide. Toward further advancement of gene therapy for hemophilia, we have previously developed and validated the efficacy of novel two types of gene transfer technologies using a mouse model of hemophilia A. Here we investigated the efficacy and safety of the technologies in canine model. Especially, validations of technical procedures of the gene transfers for dogs were focused. Methods: Green fluorescence protein (GFP) gene were transduced into normal beagle dogs by ex vivo and in vivo gene transfer techniques. For ex vivo gene transfer, blood outgrowth endothelial cells (BOECs) derived from peripheral blood of normal dogs were transduced with GFP gene using lentivirus vector, propagated, fabricated as cell sheets, then implanted onto the omentum of the same dogs. For in vivo gene transfer, normal dogs were subjected to GFP gene transduction with non-viral piggyBac vector by liver-targeted hydrodynamic injections. Results: No major adverse events were observed during the gene transfers in both gene transfer systems. As for ex vivo gene transfer, histological findings from the omental biopsy performed 4 weeks after implantation revealed the tube formation by implanted GFP-positive BOECs in the sub-adipose tissue layer without any inflammatory findings, and the detected GFP signals were maintained over 6 months. Regarding in vivo gene transfer, analyses of liver biopsy samples revealed more than 90% of liver cells were positive for GFP signals in the injected liver lobes 1 week after gene transfers, then the signals gradually declined overtime. Conclusions: Two types of gene transfer techniques were successfully applied to a canine model, and the transduced gene expressions persisted for a long term. Toward clinical application for hemophilia patients, practical assessments of therapeutic efficacy of these techniques will need to be performed using a dog model of hemophilia and FVIII (or FIX) gene.博士（医学）・乙第1517号・令和3年12月21日© 2021, The Japanese Society for Regenerative Medicine. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/ 4.0/)

Things to Change College Students’ Consciousness by Stories from Family Members of People with Intellectual Disabilities: From the Questionnaire Analysis in Classes Targeting Students at Faculty of Education

本稿では，本学教育学部１年次生を対象とした教養ゼミ（講義型）において，障害のある子どもの保護者による当事者参加型授業を実施し，その効果について検討した。障害（者）に対する理解を測る質問紙を用いた分析の結果では，［保護者の思い］を聞くことで，障害（者）理解への新たな視点を得られたことが明らかになった。受講学生に対して「今あるいはこれから自分にできると思う取り組み」について質問し，質的分析を行った。結果から，［障害者とのかかわり方］［障害（者）についての認識］［持続的探求］が抽出された。障害のある子どもの保護者による教育学部１年次生への授業は，将来，教育に携わろうとする学生にとっては，障害（者）の理解に加え，自分が今後取り組むべきことがより教育と結びついた形で明確になったと推察された。In this study, a lecture with active participation of parents of children with disabilities was held in a lecture-type educational seminar for the freshmen of the department of education and its effectiveness was examined. The results of the analysis of the questionnaire designed to measure the degree of understanding of disabilities and people with disabilities revealed that students had acquired a new perspective for understanding disabilities and people with disabilities by listening to the parents’ thoughts and feelings. The students who attended the class were asked about what they thought they could do at present or in the future, and the results were qualitatively analyzed. “How to interact with people with disabilities,” “recognition of disabilities and people with disabilities,” and “sustainable exploration” were extracted from the results. It was speculated that the class with active participation of parents with children with disabilities helped the students planning to be engaged in education in the future to clarify what they should do in the future in relation to education as well as understand disabilities and people with disabilities

Control of phosphate appetite in young rats

In the present study, we investigated whether a diet deficient in inorganic phosphate (Pi) stimulates an ingestive behavior to seek sources of Pi. Male Wistar rats were placed in individual cages with unrestricted access to tap water and a low (LPD, 0.02% Pi) or normal (NPD, 0.6% Pi) Pi diet for 6 days. On day 7, LDP rats were given unlimited access to a solution of 25 mM potassium phosphate water (Pi-water) for 9 additional days. Rats fed LPD consumed 70-100% more Pi-water then those fed NPD. The increase in Pi-water intake resulted in a marked rise in the growth rate of rats fed LPD during day 9. A similar intake of Pi was induced after only 2 days of LPD and was associated with significant reductions in both plasma and cerebrospinal fluid (CSF) levels of Pi ; these levels remained low throughout Pi restriction, despite a significant intake of Pi-water. Replenishment with a high-Pi diet rapidly quenched the appetite for Pi-water and was associated with restoration of both plasma and CSF Pi levels. These findings suggest that an appetite for Pi can be induced in rats, perhaps through lowered plasma and CSF Pi levels

Study of learning environment development of the way to become the foundation of inclusive education system : From teaching practice in a special classroom by teachers in regular class

本校では特別支援学級と複式学級の教科による交流及び共同学習の導入や，学級交流や縦割り学習，運動会等の校内行事での交流などに取り組んできている。本研究は，これまでの成果を基に，通常の学級に在籍する児童の多様性や障害の理解を促す実践を交流及び共同学習や教科学習の中で行い，その効果を検証することを目的とした。特別支援学級の担任ではない教員が，特別支援学級の指導案を作成することを通して，日頃の交流だけではとらえられない特別支援児童の実態に気づき，支援の在り方について検討する。また実際に授業を行うことで特別支援領域に関する見方・考え方を活用し，それぞれの学級の児童支援に生かし，共有できるようにした。授業を行う教員の研究教科が算数科であることから算数科で授業を行うこととし，都合５時間の特別支援学級教員による算数科の授業を観察，児童の実態把握を行い，聞き取りも含め授業構想を行っていった。実際の授業から，子どもたちの中に価値に関する概念が育成されているかどうかの違いがあることに気付く。価値概念の育成や獲得方法を明らかにしていくことによって小学校の教科の指導をより充実させていくことができると考えた。Do the practice of promoting an understanding of the children of diversity and disorder enrolled in regular classes in the exchange and collaborative learning and subject learning, was aimed to verify the effect. Special support is not a homeroom class faculty, through to create a lesson plan of the special support class, noticed the actual situation of the special support children that cannot be captured only daily exchanges, as well as consider the way of support, the teaching plan actually take advantage of the special support area on the perspective, the concept by making the class alive, it was decided to continue making the child support of each class. It was thought to be able to go to enrich more the guidance of the subjects of elementary school by going to reveal the development and acquisition method of one person a child of the value of the concept

Prediction of p53 target genes based on integrative analysis of chromatin immunoprecipitated and sequenced tags，by using Galaxy，a web-based interactive platform for large-scale genome analysis

Chromatin immunoprecipitation (ChIP) followed by sequencing of immunoprecipitated DNA fragments is the high throughput method for identifying transcription factor binding sites. In one such method, ChIP PET, paired end ditags (PETs) derived from both ends of the immunoprecipitated DNA fragments are sequenced and mapped to the genome. We report here the prediction of p53 target genes by meta analyzing tags of p53 ChIP PET and by combining with other genomic annotations, using Galaxy, a web based platform for large scale genome analysis. We found 327 of p53 binding sites on the genome of 5-fluorouracil (5-FU)-treated HCT116 colon cancer cells by searching the total 65,509 PETs for PET clusters. The search for p53 target gene, which focused on PET clusters with computationally-predicted p53 binding motif, identified 20 of putative p53 target genes as well as 11 of known p53 targets. Another search for p53 target genes, which focused on PET clusters located within 50-kb flanking regions of transcription start sites of genes, identified 278 of Refseq genes, 79 of non-coding RNAs and 5 of microRNAs as p53 targets which included lots of known validated targets. Our results indicate that sequencing-based ChIP analysis combined with the existing genome annotation is effective method to predict p53 binding loci and target genes, and also show that the Galaxy platform is well-suited for multiple-type analyses and visualization of ChIP data, leading to functional annotation of transcription factor binding sites

The Gender–Age–Physiology system as a prognostic model in patients with idiopathic pulmonary fibrosis treated with nintedanib: a longitudinal cohort study

Introduction: The Gender-Age-Physiology (GAP) system is a tool for predicting prognosis in patients with idiopathic pulmonary fibrosis (IPF). Yet, to date, the GAP system has not been evaluated in patients with IPF who received nintedanib. Material and methods: This single-center retrospective study included 89 patients with IPF who received Nintedanib for at least 3 months. All-cause mortality was set as the end point. Clinical parameters, including the GAP stage, were statistically analyzed for risk factors leading to mortality using the Cox proportional hazard model.Results: The median follow-up was 16.4 months (range 3.7–37.4 months), during which 23 patients died. Univariate analysis revealed that the GAP stage (hazard ratio [HR] 3.00, 95% confidence interval [CI] 1.52–5.92, p = 0.0014) and PaO2 (HR 0.95, 95% CI 0.92–0.98, p = 0.0063) were significant prognostic factors. Multivariate analysis revealed that the GAP stage was a significant prognostic factor (HR 2.26, 95% CI 1.07–4.78, p = 0.031). Log-rank analysis revealed that there were no significant differences in “Gender” (p = 0.47) and “Age” (p = 0.18) factors. However, there were significant differences in “Physiology” factors (% of forced vital capacity, p = 0.018; % of diffusing capacity of lung carbon monoxide, p < 0.001). The cumulative incidences of mortality at 1 and 2 years were as follows: GAP I: 5.1% and 6.8%; GAP II: 9.5% and 29.3%; and GAP III: 18.9% and 84.2%.Conclusions: The GAP system is useful as a prognostic tool in patients with IPF who have been treated with nintedanib