玄米麹菌発酵食品が四塩化炭素肝障害マウスに及ぼす影響

　玄米麹菌発酵食品は無農薬玄米を原料として麹菌（Aspergillus Niger）にて発酵した後、乾燥させた食品である。玄米麹菌発酵食品は、麹菌による発酵により、100g中に4gの核酸成分が含有されているのが特徴である。玄米麹菌発酵食品は、血糖値の上昇抑制効果、小腸粘膜の保護効果を認めている。本研究では、 玄米麹菌発酵食品による肝障害軽減効果について、四塩化炭素肝障害マウスを用いて検討を行った。その結果、トランスアミナーゼ活性値、SOD活性値に有意な差が示された。組織学的所見では肝組織損傷の抑制効果が確認された。したがって玄米麹菌発酵食品には四塩化炭素肝障害の軽減作用があることが示唆された。玄米麹菌発酵食品の摂取は急性肝炎の軽減効果、また肝機能保護効果にも有用であると考えられ、今後、玄米麹菌発酵食品の機能性食品としての応用が期待される

The impact of building up the limb muscle mass by the resistance exercise with the intake of milk in middle-aged and elderly women

Background: In the rapidly aging Japanese society, the most serious disorder to prevent is sarcopenia for extending healthy life expectancy. Objective: This study was carried out to clarify whether five kinds of specific and simple resistance exercise performing at home for the short term (42 days) with theintake of whole milk could help to increase the limb muscle mass in middle-aged and elderly women. Participants and measurements: Subjects were 39 healthy women aged 50 to 80 years who gave the consent to participate in the present study. Body composition, physical fitness, food and nutrient intake were measured. Oral glucose-tolerance test (OGTT) was also performed. Groups and results: Subjects were categorized in two groups; Group I with the increase of the limb muscle mass after exercise and Group II with no increase. Body weight before exercise (Group I, 51.6±5.5 kg vs Group II, 58.5±10.3 kg), the body mass index (BMI) (21.7±2.5 kg/m2 vs 24.3±3.9 kg/m2), the limb muscle mass (14.4±1.3 kg vs 15.6±2.0 kg), the skeletal muscle mass index (SMI) (6.0±0.5 kg/m2 vs 6.5±0.7 kg/m2), were all significantly high in Group II. The intake of milk before exercise in Group I (162.1±103.7 g/day) was significantly higher than in Group II (92.5±63.3 g/day). The blood glucose level at 30 min after glucose loading in Group I before exercise was significantly higher than that in Group Ⅱ (199.3 ± 31.1 mg/dl vs 177.0±34.1 mg/dl). Conclusion: The subjects in Group I could successfully increase the limb muscle mass, but the subjects in Group II, whose weight, BMI, the limb muscle mass were significantly high before exercise, could not increase the muscle mass by resistance exercise with the intake of milk. It was considered that the resistance exercise carried out in this study was not strong enough for Group II. We assumed that the BMI value could be the indicator of the strength of exercise for building up the muscle mass in middle-aged and elderly individuals

卵巣摘出ラットに対する低分子化ライチポリフェノール「OligonolⓇ」の肥満予防効果

　成人女性は女性ホルモンであるエストロゲンの分泌の低下および停止により、概ね50歳前後で閉経を迎え、それに伴う身体変化として体重増加、体脂肪の増加がみられる。今回、生体内への吸収性を高めた低分子化ライチポリフェノール（a standardized oligomerized-polyphenol from Litchi chinensis fruit extract）である「Oligonol®」を閉経モデルである卵巣摘出ラットに対して2か月間の経口投与を行い、その肥満予防効果を検討した。　結果、Oligonol®100mg/kg経口投与により、食餌摂取量の増加抑制に伴い体重変化率、血清レプチン濃度の増加抑制がみられた。ラットにおける卵巣摘出は摂食量の増加を通じて肥満を誘発するが、Oligonol®100mg/kg経口投与は、摂食量を摘出前のレベルに近づけることで、体重増加と血清レプチン濃度も摘出前のレベルに近づけることが示唆された

Flow cytometric analysis of skin blister fluid induced by mosquito bites in a patient with chronic active Epstein-Barr virus infection

金沢大学医薬保健研究域医学系In chronic active Epstein-Barr virus (EBV) infection (CAEBV), ectopic EBV infection has been described in T or natural killer (NK) cells. NK cell-type infection (NK-CAEBV) is characterized by large granular lymphocytosis, high IgE levels and unusual reactions to mosquito bites, including severe local skin reactions, fever and liver dysfunction. However, the mechanisms underlying these reactions remain undetermined. Herein, we describe a patient with NK-CAEBV whose blister fluid after mosquito bites was analyzed. The patient exhibited significant increases in the percentage of CD56+ NK cells in the fluid compared with a simple mosquito allergy, in which the majority of infiltrated cells were CD203c+ cells, indicating basophils and/or mast cells. His fluid also contained CD203c+ cells, and his circulating basophils were activated by mosquito extracts in vitro. These results suggest that CD203c+ cells as well as NK cells may play pathogenic roles in the severe skin reactions to mosquito bites in NK-CAEBV. © 2009 The Japanese Society of Hematology.出版者に照会中.2010年12月より全文公開予定

Hot Electron Spectra in Plain, Cone and Integrated Targets for FIREX-I using Electron Spectrometer

The traditional fast ignition scheme is that a compressed core created by an imploding laser is auxiliary heated and ignited by the hot electrons (produced by a short pulse laser guided through the cone). Here, the most suitable target design for fast ignition can be searched for by comparison of the spectra between varied targets using an electron spectrometer