2-(4-Bromo­phen­oxy)propanohydrazide

The title compound, C9H11BrN2O2, is an important inter­mediate for the synthesis of heterocyclic compounds such as azoles, 2,5-disubstituted-1,3,4-oxadiazo­les and 5-substituted 2-mercapto-1,3,4-oxadiazo­les. The bromo­phen­oxy group subtends a dihedral angle of 82.81 (7)° with the plane passing through the propanohydrazide moiety. The crystal structure is stabilized by inter­molecular N—H⋯O hydrogen bonds that form columns extending along the b axis

4-(4-Propoxybenzo­yloxy)benzoic acid

The title compound, C17H16O5, is an important inter­mediate for the synthesis of side-chain ligands for polymeric liquid crystals. The prop­oxy and benzoic acid groups subtend dihedral angles of 4.36 (6) and 55.35 (6)°, respectively, with the central benzo­yloxy unit. The crystal structure is stabilized by an inter­molecular O—H⋯O hydrogen bond

Cross-priming for antitumor CTL induced by soluble Ag + polyI:C depends on the TICAM-1 pathway in mouse CD11c+ /CD8α+ dendritic cells

PolyI:C is a nucleotide pattern molecule that induces cross-presentation of foreign Ag in myeloid dendritic cells (DC) and MHC Class I-dependent proliferation of cytotoxic T lymphocytes (CTL). DC (BM or spleen CD8α(+)) have sensors for dsRNA including polyI:C to signal facilitating cross-presentation. Endosomal TLR3 and cytoplasmic RIG-I/MDA5 are reportedly responsible for polyI:C sensing and presumed to deliver signal for cross-presentation via TICAM-1 (TRIF) and IPS-1 (MAVS, Cardif, VISA) adaptors, respectively. In fact, when tumor-associated Ag (TAA) was simultaneously taken up with polyI:C in DC, the DC cross-primed CTL specific to the TAA in a syngenic mouse model. Here we tested which of the TICAM-1 or IPS-1 pathway participate in cross-presentation of tumor-associated soluble Ag and retardation of tumor growth in the setting with a syngeneic tumor implant system, EG7/C57BL6, and exogenously challenged soluble Ag (EG7 lysate) and polyI:C. When EG7 lysate and polyI:C were subcutaneously injected in tumor-bearing mice, EG7 tumor growth retardation was observed in wild-type and to a lesser extent IPS-1(−/−) mice, but not TICAM-1(−/−) mice. IRF-3/7 were essential but IPS-1 and type I IFN were minimally involved in the polyI:C-mediated CTL proliferation. Although both TICAM-1 and IPS-1 contributed to CD86/CD40 upregulation in CD8α(+) DC, H2K(b)-SL8 tetramer and OT-1 proliferation assays indicated that OVA-recognizing CD8 T cells predominantly proliferated in vivo through TICAM-1 and CD8α(+) DC is crucial in ex vivo analysis. Ultimately, tumor regresses > 8 d post polyI:C administration. The results infer that soluble tumor Ag induces tumor growth retardation, i.e., therapeutic potential, if the TICAM-1 signal coincidentally occurs in CD8α(+) DC around the tumor

2-Benzoyl-1-(2,4-dichloro­phen­yl)-3-phenyl­guanidine

In the title compound, C20H15Cl2N3O, a typical polysubstituted guanidine with normal geometric parameters, the torsion angles [C—N—C—O = 3.8 (2), N—C—N—C = −6.1 (2)°] indicate that the guanidine and carbonyl groups are almost coplanar, due to the pseudo-hexa­gonal ring formed by intra­molecular N—H⋯O hydrogen bonds. The crystal packing is stabilized by inter­molecular N—H⋯O hydrogen bonds, which link the mol­ecules into centrosymmetric dimers

Dicyclo­hexyl­ammonium thio­cyanate

In the crystal structure of the title compound, C12H24N+·NCS−, the anions and cations are linked through N—H⋯N and N—H⋯S hydrogen bonds, resulting in a chain along the a axis

An Early Stage Diffuse B-Cell Lymphoma Within a Visible Site of Bronchofiberscope Accompanied by Peripheral Lung Cancer

We report a case of non-Hodgkin's lymphoma found at the orifice of right B2 accompanied by peripheral lung cancer in a 66-year-old asymptomatic man. Chest X-ray films showed a mass shadow in the left lower lung field. Transbronchial lung biopsy of left S9 demonstrated squamous cell carcinoma. Simultaneously wall thickening at the orifice of the right B2 was found coincidentally. The biopsy specimen from that site showed non-Hodgkin's lymphoma (diffuse B-cell type). After left lower lobectomy, systemic chemotherapy was performed. It is rare for malignant lymphoma to be recognized bronchofiberscopically

Isopropyl 2-[2-(2,6-dichloro­anilino)phen­yl]acetate

In the title compound, C17H17Cl2NO2, the NH group exhibits an intra­molecular hydrogen bond to the carbonyl O atom and no inter­molecular hydrogen bonding, in contrast with previous studies. The dihedral angle between the two benzene rings is 58.57 (5)°. The ester group is planar, the greatest deviation from planarity being 0.0135 (11) Å for the ether O atom