The Relationship between the Unit Learning Theory and Literary Education in Early Post-war : Focus on the idea generation of thematic unit in Japanese language arts

In this paper, I considered how literary education entered to unit learning theory in early post-war. In general, it was thought the unit learning does not intersect with the literary education in those days. Because, the people who advocated the literary education were criticized the unit learning theory. But, there was a movement tried though them by the following ways: 1) To extend the meaning of language experiences; 2) To regard as the unit by combining the teaching materials. I concluded they are the application of the concept continued from pre-war by using concept of US

戦後国語科における単元学習の展開に関する研究 : 主題単元学習の展開と可能性

内容の要約広島大学(Hiroshima University)博士(教育学)Doctor of Philosophy in Educationdoctora

The role of iron in obesity and diabetes

Iron is an essential trace metal for all life, but excess iron causes oxidative stress through catalyzing the toxic hydroxy-radical production via the Fenton reaction. The number of patients with obesity and diabetes has been increasing worldwide, and their onset and development are affected by diet. In both clinical and experimental studies, a high body iron content was associated with obesity and diabetes, and the reduction of body iron content to an appropriate level can ameliorate the status and development of obesity and diabetes. Macrophages play an essential role in the pathophysiology of obesity and diabetes, and in the metabolism and homeostasis of iron in the body. Recent studies demonstrated that macrophage polarization is related to adipocyte hypertrophy and insulin resistance through their capabilities of iron handling. Control of iron in macrophages is a potential therapeutic strategy for obesity and diabetes

The Formation Process of Thematic Unit in Japanese Language Education in the 1970s : In the case of practical research by Hiroshima University High School

In this paper, I considered the formation process of the thematic unit in Japanese education in the 1970s. The 1970s is very important period, because many theorists who insisted on the thematic unit refer to the practical research by Hiroshima University High School in 1970s. This practical research was born by the following situations. 1. In Japanese language education, the recovery of the human nature has been demanded. 2. When students learn the literature, teachers had set the pursuit of humanity to the goal from before. 3. Japanese language education textbook that was used by Hiroshima University High School (Be made by SANSEIDO Co.,Ltd.) was composed of the thematic units. These situations was formed the thematic unit of the 1970s. And, the practical research by Hiroshima University High School was to have a big influence

Control of the incorporation and release of guest molecules by photodimerization in liposomes

In a drug-delivery system using liposomes, the use of guest molecules bearing hydrophilic moieties results in some leakage from lipid membranes. We suppressed the leakage of coumarins (used as model guest molecules in a drug-delivery system) from lipid membranes by photodimerization at 365 nm. The reason for this phenomenon could be ascribed to an increase in the hydrophobicity of the dimers of the coumarins. The formation of the dimers was detected by 1H NMR, UV-vis absorption, and mass spectra and the leakage percentages of the coumarins were determined by 1H NMR spectra based on the peak intensities. In contrast, when the dimer reverted to a monomer by ultraviolet (254 nm) irradiation, the resulting monomer was released from liposomes.This work was supported by a JSPS KAKENHI Grant-in-Aid for Scientific Research (B) (Grant No. JP16H04133) and a Grant-in-Aid for Challenging Exploratory Research (Grant No. JP16K13982)

COVID-19と心疾患

Coronavirus disease-2019（COVID-19） induces of multi-organs damage including heart, vessels, and lung neurological systems in addition to respiratory disorders, causing subsequent complications. Patients with cardiovascular damage induced by COVID-19 show ischemic heart disease, arrhythmias, and venous thromboembolism, resulting in death. Patients with a medical history of hypertension, diabetes, and coronary artery disease are associated with an increased rate of aggravation and mortality. It is very important to prevent the onset of cardiovascular complications caused by COVID-19, however, there are no therapeutics for them and new treatments and therapeutic agents need to be developed. Kampo medicine is a traditional Japanese herbal medicine and has been attracting attention in the treatment of COVID-19. This article outlines the pathophysiological findings of COVID-19-related cardiovascular complications and the potential effect of Kampo as supportive care against it

TJ-17 (Goreisan) mitigates renal fibrosis in a mouse model of folic acid-induced chronic kidney disease

Background and purpose: TJ-17 (Goreisan), a traditional Japanese Kampo medicine, has been generally used to treat edema, such as heart failure, due to its diuretic effect. In the present study, we investigate the effects of TJ-17 on chronic kidney disease (CKD). Methods: We the preventive action of TJ-17 against acute kidney injury (AKI) transition to CKD in vivo using a folic acid (FA)-induced mouse model. Mice were treated with food containing TJ-17 at 48 h after FA intraperitoneal injection (AKI phase). Results: Histological analysis, as well as renal function and renal injury markers, deteriorated in mice with FA-induced CKD and were ameliorated by TJ-17 treatment. Increased levels of inflammatory cytokines and macrophage infiltration were also alleviated in mice treated with TJ-17. Renal fibrosis, a crucial factor in CKD, was induced by FA administration and inhibited by TJ-17 treatment. Pretreatment with TJ-17 did not exert an inhibitory effect on FA-induced AKI. The increase in urinary volume in FA-induced CKD mice was ameliorated by TJ-17 treatment, with a concurrent correction of reduced aquaporins expression in the kidney. Conclusion: TJ-17 may have a novel preventive effect against inflammation, oxidative stress, and fibrosis, contributing to innovation in the treatment of CKD

Development of Discussion Instruction with Inevitable Use of ICT in Japanese Language Studies at High School: Setting up a “Non-private Relationship” Place Through Connections Between Different Schools

国語教育学研究における話し合い指導は，現実的な制約から教室内の関係の中で展開されるものにとどまっていた。その結果，公的な関係での話し合いの場が設定されにくい現状にあった。しかしながら，ICTの活用を通して学校間を繋ぐことによって，関係性の築き上げられていない関係での話し合いの場の設定が可能になる。そこで，ICTの活用による文字化資料の作成の効率化などの利点も取り入れながら，実際に県を跨いで高等学校間を接続し，話し合いを行うとともに，その話し合いの対象化を行う実践を開発，展開した。結果，学習者は学校間の接続に肯定的な評価を示すとともに，方法知の獲得の土台となるであろう認識を獲得したことを明らかにした