2 research outputs found
Obesity-Related Metabolomic Profiles and Discrimination of Metabolically Unhealthy Obesity
A particular subgroup of obese adults,
considered as metabolically
healthy obese (MHO), has a reduced risk of metabolic complications.
However, the molecular basis contributing to this healthy phenotype
remains unclear. The objective of this work was to identify obesity-related
metabolite patterns differed between MHO and metabolically unhealthy
obese (MUHO) groups and examine whether these patterns are associated
with the development of cardiometabolic disorders in a sample of Iranian
adult population aged 18–50 years. Valid metabolites were defined
as metabolites that passed the quality control analysis of the study.
In this case-control study, 104 valid metabolites of 107 MHO and 100
MUHO patients were separately compared to those of 78 normal-weight
metabolically healthy (NWMH) adults. Multivariable linear regression
was used to investigate all potential relations in the study. A targeted
metabolomic approach using liquid chromatography coupled to triple
quadrupole mass spectrometry was employed to profile plasma metabolites.
The study revealed that, after Bonferroni correction, branched-chain
amino-acids, tyrosine, glutamic acid, diacyl-phosphatidylcholines
C32:1 and C38:3 were directly and acyl-carnitine C18:2, acyl-lysophosphatidylcholines
C18:1 and C18:2, and alkyl-lysophosphatidylcholines C18.0 were inversely
associated with MHO phenotype. The same patterns were observed in
MUHO patients except for the acyl-carnitine and lysophosphatidylcholine
profiles where acyl-carnitine C3:0 and acyl-lysophosphatidylcholine
C16:1 were higher and acyl-lysophosphatidylcholines C18:1, C18:2 were
lower in this phenotype. Furthermore, proline, and diacyl-phosphatidylcholines
C32:2 and C34:2 were directly and serine, asparagines, and acyl-alkyl-phosphatidylcholine
C34:3 were negatively linked to MUHO group. Factors composed of amino
acids were directly and those containing lysophosphatidylcholines
were inversely related to cardiometabolic biomarkers in both phenotypes.
Interestingly, the diacyl-phosphatidylcholines-containing factor was
directly associated with cardiometabolic disorders in the MUHO group.
A particular pattern of amino acids and choline-containing phospholipids
may aid in the identification of metabolic health among obese patients
Obesity-Related Metabolomic Profiles and Discrimination of Metabolically Unhealthy Obesity
A particular subgroup of obese adults,
considered as metabolically
healthy obese (MHO), has a reduced risk of metabolic complications.
However, the molecular basis contributing to this healthy phenotype
remains unclear. The objective of this work was to identify obesity-related
metabolite patterns differed between MHO and metabolically unhealthy
obese (MUHO) groups and examine whether these patterns are associated
with the development of cardiometabolic disorders in a sample of Iranian
adult population aged 18–50 years. Valid metabolites were defined
as metabolites that passed the quality control analysis of the study.
In this case-control study, 104 valid metabolites of 107 MHO and 100
MUHO patients were separately compared to those of 78 normal-weight
metabolically healthy (NWMH) adults. Multivariable linear regression
was used to investigate all potential relations in the study. A targeted
metabolomic approach using liquid chromatography coupled to triple
quadrupole mass spectrometry was employed to profile plasma metabolites.
The study revealed that, after Bonferroni correction, branched-chain
amino-acids, tyrosine, glutamic acid, diacyl-phosphatidylcholines
C32:1 and C38:3 were directly and acyl-carnitine C18:2, acyl-lysophosphatidylcholines
C18:1 and C18:2, and alkyl-lysophosphatidylcholines C18.0 were inversely
associated with MHO phenotype. The same patterns were observed in
MUHO patients except for the acyl-carnitine and lysophosphatidylcholine
profiles where acyl-carnitine C3:0 and acyl-lysophosphatidylcholine
C16:1 were higher and acyl-lysophosphatidylcholines C18:1, C18:2 were
lower in this phenotype. Furthermore, proline, and diacyl-phosphatidylcholines
C32:2 and C34:2 were directly and serine, asparagines, and acyl-alkyl-phosphatidylcholine
C34:3 were negatively linked to MUHO group. Factors composed of amino
acids were directly and those containing lysophosphatidylcholines
were inversely related to cardiometabolic biomarkers in both phenotypes.
Interestingly, the diacyl-phosphatidylcholines-containing factor was
directly associated with cardiometabolic disorders in the MUHO group.
A particular pattern of amino acids and choline-containing phospholipids
may aid in the identification of metabolic health among obese patients