Additional file 1: Table S1. of Hormonal responses to non-nutritive sweeteners in water and diet soda

Ingredients in diet sodas. (DOCX 11 kb

Additional file 2: Figure S1. of Hormonal responses to non-nutritive sweeteners in water and diet soda

Serial data from OGTTs. Acetaminophen (A) and 3-O-methyl glucose (3-OMG) (B) are shown after ingestion of either Diet Rite Cola™ (red square), or seltzer water (blue circle) 10 min prior to a 75 g oral glucose load. (PDF 321 kb

Hormonal characteristics of study subjects.

1<p>Values are reported as median with interquartile range due to skewed distribution.</p>a<p>To convert gravimetric units for hormones to SI units, use the following conversion factors: cortisol, µg/dl * 27.59 =  nmol/l; epinephrine, µg/24 h * 5.46 =  nmol/24 h; NE, µg/24 h * 5.91 =  nmol/24 h; corticotropin (ACTH), pg/ml * 0.22 =  pmol/l; and dopamine, µg/24 h *6.58 =  nmol/24 h; IGF-1, ng/mL*0.131 =  nmol/L.</p

Glucowse characteristics for study subjects during fasting conditions and the oral glucose tolerance test.

<p>Unless otherwise stated, values in each cell are reported as mean ± SD or as percentage.</p>1<p>Values are reported as median with interquartile range due to skewed distribution.</p

Fasting glucose concentration increases with sleep apnea severity as quantified by the RDI score.

<p>Fasting glucose concentrations rose progressively from subjects without sleep apnea (84.9±6.7 mg/dL; mean±SD) to those with mild (90.4±12.9 mg/dL), moderate (92.5±8.9 mg/dL), and severe (93.9±17.9 mg/dL) sleep apnea (test for trend: <i>p</i> = 0.025). Data are presented as mean with 95% CI.</p

Inflammatory/immune characteristics of study subjects.

<p>Values are reported as median with interquartile range due to skewed distribution.</p>*<p>N = 87</p

Relationship between RDI and fasting glucose (Panel A), fasting insulin (Panel B), HOMA index (Panel C), and 120-min glucose (Panel D).

<p>RDI is reported on a <i>safe</i>-logarithmic scale, namely, LOG₁₀(1+ RDI).</p

Demographic and anthropometric characteristics of the study subjects.

<p>Values in each cell are reported as mean ± SD or as percentage.</p

Sleep characteristics of study subjects.

<p>Unless otherwise stated, values in each cell are reported as mean ± SD or as percentage.</p>1<p>RDI values are reported as median with interquartile range due to its skewed distribution.</p