19 research outputs found
Forest plot of odds ratios (95% confidence intervals) for the effect of simvastatin on AMD progression from different models of the analysis.
<p>Forest plot of odds ratios (95% confidence intervals) for the effect of simvastatin on AMD progression from different models of the analysis.</p
Logistic regression analysis of simvastatin effect on AMD progression.
<p>*Adjusted for age, sex, smoking, and unilateral advanced AMD.</p
Baseline characteristics of placebo and simvastatin study groups.
<p>Baseline characteristics of placebo and simvastatin study groups.</p
Lipid levels at baseline and follow-up by treatment allocation.
<p>*P value from paired samples t-test, comparing baseline and follow-up measurements in each treatment group.</p><p>**P value from independent samples t-test comparing the differences (baseline level minus follow-up level) between the two treatment groups.</p
AMD progression by treatment allocation and genotypes of the <i>CFH</i> and <i>APOE</i> genes.
<p>Note: Interactions between genotype and simvastatin were tested in a sequential regression model, with treatment group and genotype entered in the first stage and interaction between these two variables entered in the second stage. Coefficients shown are from stage 1 model for the treatment group and genotype variables and from stage 2 for interactions.</p><p>*Adjusted for age, smoking, sex and unilateral advanced AMD.</p
Macular characteristics used to determine severity in non-advanced age-related macular degeneration.
<p>*Category ‘Number’ is related to drusen only.</p
Time course of subretinal hemorrhage in P1, as documented with retinal fundus photography.
<p>Complete resolution of the hemorrhage occurred in this subject by 55 days post-operatively. Note the electrode array with individual electrodes can be seen more clearly over time as the blood clears in the temporal retina (arrow).</p
Potential anatomical locations for retinal prosthesis implantation.
<p>To date, clinical trials have been performed with devices in the A: epiretinal position <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0115239#pone.0115239-Humayun3" target="_blank">[15]</a>, B: subretinal space <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0115239#pone.0115239-Zrenner2" target="_blank">[7]</a> and D: intrascleral space <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0115239#pone.0115239-Fujikado2" target="_blank">[19]</a>. Image modified with permission from Bionic Vision Australia.</p
OCT scan of the electrode array in situ, taken 2 months postoperatively in Patient 1.
<p>The horizontal arrow on the infrared image indicates the direction of the OCT scan (A). The cross-sectional OCT image (B) shows the silicone and platinum electrode components of the array, the retina structure and choroidal vasculature, and the electrode to retina distance used for analysis (double-headed arrow). Scale bars  =  200 µm.</p