Thiol-reactive analogues of galanthamine, codeine and morphine as potential probes to interrogate allosteric binding within nAChRs

Alkaloids including galanthamine (1) and codeine (2) are reported to be positive allosteric modulators of nicotinic acetylcholine receptors (nAChRs) but the binding sites responsible for this activity are not known with certainty. Analogues of galanthamine (1), codeine (2) and morphine (3) with reactivity towards cysteine thiols were synthesised including conjugated enone derivatives of the three alkaloids 4-6 and two chloro-alkane derivatives of codeine 7 and 8. The stability of the enones was deemed sufficient for use in buffered aqueous solutions and their reactivity towards thiols was assessed by determining the kinetics of reaction with a cysteine derivative. All three enone derivatives were of sufficient reactivity and stability to be used in covalent trapping, an extension of the substituted cysteine accessibility method (SCAM), to elucidate the allosteric binding sites of galanthamine and codeine at nAChRs

Letter, 1953 September 2, from Mary McLeod Bethune to Eva Jessye

1 page, Bethune was the president of the Mary McLeod Bethune Foundation

Alien Registration- Mcleod, Mary J. (South Portland, Cumberland County)

https://digitalmaine.com/alien_docs/20141/thumbnail.jp

Notes: National Association of Colored Women, State Federation of Colored Women\u27s Club

Treasurer\u27s account of 1922 and receipt signed by Mary McLeod Bethune. Written on back of The University of Florida General Extension Division Correspondence-Study Department paper: Ocala Fla. June 30, 1922. State Federation C.W.C. Received of State Treasurer One hundred nineteen dollars and fifty-two cents $119.52 Balance in treasur due nothing. Mary McLeod Bethune” List transcript added as supplemental fil

Mary McLeod Bethune Night Program

Program for Mary McLeod Bethune Night, a Musical and Hymnal Festival, Ebenezer Methodist Church, Jacksonville, Florida

Exploring Shifting Landscapes

Research Poste

Solving Real World Problems With Alternate Reality Gaming: Student Experiences in the Global Village Playground Capstone Course Design

The Global Village Playground (GVP) was a capstone learning experience designed to address institutional assessment needs while providing an integrated and authentic learning experience for students aimed at fostering complex problem solving, as well as critical and creative thinking. In the GVP, students work on simulated and real-world problems as a design team tasked with developing an alternate reality game that makes an impact on the United Nations Millennium Development Goals. Researchers employed a qualitative case study approach to evaluate what aspects of this problem-based, hybrid, course design students found most and least beneficial to their learning. Findings suggest strategies for designing technology-based learning environments to support complex problem solving. Specific recommendations pertain to scaffolding team-based problem solving, particularly concept development processes, interdependence among team members, and group self-organization

Marshall Space Flight Center Technology Capabilities for Use in Space Situational Awareness Activities

Marshall performs research, integrates information, matures technologies, and enhances science to bring together a diverse portfolio of products and services of interest for Space Situational Awareness (SSA) and Space Asset Management (SAM), all of which can be accessed through partnerships with Marshall. Integrated Space Situational Awareness and Asset Management (ISSAAM) is an initiative of NASA's Marshall Space Flight Center to improve space situational awareness and space asset management through technical innovation, collaboration, and cooperation with U.S. Government agencies and the global space community. Marshall Space Flight Center provides solutions for complex issues with in-depth capabilities, a broad range of experience, and expertise unique in the world, and all available in one convenient location. NASA has longstanding guidelines that are used to assess space objects. Specifically, Marshall Space Flight Center has the capabilities, facilities and expertise to address the challenges that space objects, such as near-Earth objects (NEO) or Orbital Debris pose. ISSAAM's three pronged approach brings together vital information and in-depth tools working simultaneously toward examining the complex problems encountered in space situational awareness. Marshall's role in managing, understanding and planning includes many projects grouped under each prong area: Database/Analyses/Visualization; Detection/Tracking/ Mitigation/Removal. These are not limited to those listed below

Letter from Mary McLeod Bethune to a prospective student, 1937

A cover letter from Mary McLeod bethune to a prospective student with an attached 2-page blank application for National Youth Administration student aid. The letter provides instructions to the student about filling out the application. The cover letter has an original signature from Mary McLeod Bethune

Mary C. Robinson Correspondence

Entries include brief biographical information, a handwritten letter on personal stationery explaining that copies of her book are not for sale and circulate among her friends presented with a biography, and her hopes to gain the attention of author Laura E. Richardson whose daughter Robinson had met at Maine Teachers Conventions