8 research outputs found
Characteristics of Wake Forest CHS Participants without Diabetes Defined by Glucose or Medication, According to Categories of HbA<sub>1c</sub>.
<p>Data are means (± standard deviations) or proportions.</p
Odds ratios and 95% confidence intervals for selected measures of stiffness/atherosclerosis, according to categories of HbA1c and prevalent diabetes.
1<p>Adjusted for age, gender, race (black, other), BMI, smoking status (never, former, current), total cholesterol, HDL cholesterol, antihypertensive medications, lipid-lowering medications, C-reactive protein, and creatinine.</p>2<p>Adjusted for all covariates in other multivariable models except for antihypertensive medications.</p
Associations of HbA1c and Fasting Glucose with Measures of Arterial and Ventricular Stiffness among Individuals free of Diabetes by Fasting Glucose or Medication Use.
1<p>Adjusted for age, gender, race (black, other), BMI, smoking status (never, former, current), total cholesterol, HDL-cholesterol, antihypertensive medications, lipid-lowering medications, C-reactive protein, and creatinine.</p>2<p>LV mass further adjusted for body surface area.</p
Substance use during reference period<sup>1</sup>, comparing transgender women and cisgender men.
<p>Substance use during reference period<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0197730#t003fn001" target="_blank"><sup>1</sup></a>, comparing transgender women and cisgender men.</p
HIV risk behaviors during reference period<sup>1</sup>, comparing transgender women and cisgender men.
<p>HIV risk behaviors during reference period<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0197730#t005fn001" target="_blank"><sup>1</sup></a>, comparing transgender women and cisgender men.</p
Participating studies, enrolled populations, study site, number of transgender women study participants.
<p>Participating studies, enrolled populations, study site, number of transgender women study participants.</p
Demographic characteristics of study participants, comparing transgender women and cisgender men.
<p>Demographic characteristics of study participants, comparing transgender women and cisgender men.</p
Effects of calcium, magnesium, and potassium concentrations on ventricular repolarization in unselected individuals.
Background: Subclinical changes on the electrocardiogram are risk factors for cardiovascular mortality. Recognition and knowledge of electrolyte associations in cardiac electrophysiology are based on only in vitro models and observations in patients with severe medical conditions.Objectives: This study sought to investigate associations between serum electrolyte concentrations and changes in cardiac electrophysiology in the general population.Methods: Summary results collected from 153,014 individuals (54.4% women; mean age 55.1 ± 12.1 years) from 33 studies (of 5 ancestries) were meta-analyzed. Linear regression analyses examining associations between electrolyte concentrations (mmol/l of calcium, potassium, sodium, and magnesium), and electrocardiographic intervals (RR, QT, QRS, JT, and PR intervals) were performed. The study adjusted for potential confounders and also stratified by ancestry, sex, and use of antihypertensive drugs.Results: Lower calcium was associated with longer QT intervals (-11.5 ms; 99.75% confidence interval [CI]: -13.7 to -9.3) and JT duration, with sex-specific effects. In contrast, higher magnesium was associated with longer QT intervals (7.2 ms; 99.75% CI: 1.3 to 13.1) and JT. Lower potassium was associated with longer QT intervals (-2.8 ms; 99.75% CI: -3.5 to -2.0), JT, QRS, and PR durations, but all potassium associations were driven by use of antihypertensive drugs. No physiologically relevant associations were observed for sodium or RR intervals.Conclusions: The study identified physiologically relevant associations between electrolytes and electrocardiographic intervals in a large-scale analysis combining cohorts from different settings. The results provide insights for further cardiac electrophysiology research and could potentially influence clinical practice, especially the association between calcium and QT duration, by which calcium levels at the bottom 2% of the population distribution led to clinically relevant QT prolongation by >5 ms.</p