Fragment-Based Screening of the Bromodomain of ATAD2

Cellular and genetic evidence suggest that inhibition of ATAD2 could be a useful strategy to treat several types of cancer. To discover small-molecule inhibitors of the bromodomain of ATAD2, we used a fragment-based approach. Fragment hits were identified using NMR spectroscopy, and ATAD2 was crystallized with three of the hits identified in the fragment screen

Appendix B. Daily temperature in the microenvironment of litter bags in floodplain surface, floodplain subsurface, and river channel.

Daily temperature in the microenvironment of litter bags in floodplain surface, floodplain subsurface, and river channel

Appendix C. PCA factor loading scores for the two species of litter decomposing among three habitats.

PCA factor loading scores for the two species of litter decomposing among three habitats

Appendix A. Characteristics of soils across study sites.

Characteristics of soils across study sites