25 research outputs found
Seven SNPs show sex difference.
- Author
- Adam E. Locke (418984)
- Alan R. Shuldiner (110828)
- Albert Hofman (107303)
- Albert Vernon Smith (6608)
- Aldi T. Kraja (418991)
- Alexander Teumer (112757)
- Alistair S. Hall (87549)
- Amy J. Swift (262632)
- Amélie Bonnefond (179465)
- Anders Hamsten (62728)
- Andre Scherag (5655157)
- Andrea Ganna (419008)
- Andrea Maschio (186176)
- Andres Metspalu (61760)
- Andrew A. Hicks (149966)
- Andrew David Morris (419005)
- Andrew R. Wood (149984)
- Andrew Wong (256256)
- André G. Uitterlinden (2213413)
- Anke Tönjes (103703)
- Anna-Liisa Hartikainen (110272)
- Anne U. Jackson (145702)
- Annette Peters (62601)
- Antigone S. Dimas (170915)
- Antony Paul Attwood (418993)
- Antti Jula (37961)
- Anuj Goel (258576)
- Aroon Hingorani (256127)
- Barbara Thorand (44903)
- Ben A. Oostra (122789)
- Bernhard O. Boehm (203595)
- Bernhard R. Winkelmann (237022)
- Brenda Penninx (202064)
- Bruna Gigante (256392)
- Carlo Rivolta (121162)
- Carlos Iribarren (418997)
- Carolina Medina-Gomez (152852)
- Caroline Hayward (149856)
- Caroline S. Fox (110474)
- Cecilia M. Lindgren (145706)
- Chris Power (198703)
- Christa Buechler (418988)
- Christian Gieger (87555)
- Christian Hengstenberg (44258)
- Christina Loley (418992)
- Claes Ohlsson (1924)
- Claudia Lamina (87552)
- Claudia Langenberg (160616)
- Colin N. A. Palmer (157488)
- Cornelia M. van Duijn (103685)
- Cristina Barlassina (136962)
- Damien C. Croteau-Chonka (392540)
- Daniel I. Chasman (120866)
- David Hunter (273536)
- David P. Strachan (110302)
- David Schlessinger (2399)
- Deborah J. Clegg (179176)
- Denise Anderson (125432)
- Devin Absher (217357)
- Diana Kuh (188923)
- Dmitry Shungin (198691)
- Dominique Arveiler (147942)
- Dorret I. Boomsma (109746)
- Elena Tremoli (74641)
- Elina Hyppönen (163747)
- Elizabeth K. Speliotes (145716)
- Emil Rehnberg (223827)
- Emmanouil T. Dermitzakis (120302)
- Erik Ingelsson (232651)
- Eva Albrecht (174584)
- Evelin Mihailov (419003)
- Felix R. Day (418981)
- Fernando Rivadeneira (61551)
- Francis S. Collins (82181)
- Fredrik Karpe (61681)
- Gabrielle Boucher (215508)
- Genovefa Kolovou (419007)
- George Dedoussis (160919)
- George Nicholson (106301)
- Gerjan Navis (111256)
- Gerry Fowkes (38654)
- Giancarlo Cesana (238596)
- Gonçalo R. Abecasis (36598)
- Grant W. Montgomery (131518)
- Gudmar Thorleifsson (156887)
- Guo Li (174860)
- Göran Hallmans (147486)
- H. Erich Wichmann (202082)
- Hanneke Basart (183445)
- Harald Grallert (72666)
- Harold Snieder (103613)
- Harry Campbell (30339)
- Heikki Huikuri (418996)
- Hendrik Sager (419000)
- Henrik Grönberg (122512)
- Henry Völzke (64286)
- Heribert Schunkert (44257)
- Iain Mathieson (113513)
- Ida Surakka (120325)
- Igor Rudan (150101)
- Ilja M. Nolte (238629)
- Inga Prokopenko (43252)
- Inger NjĂžlstad (211908)
- Ingrid B. Borecki (113678)
- InĂȘs Barroso (2144)
- Irene Mateo Leach (128869)
- Iris M. Heid (87553)
- Jaakko Kaprio (43154)
- Jaakko Tuomilehto (65635)
- Jaana Lindström (263654)
- Jackie F. Price (309412)
- Jacques S. Beckmann (149297)
- James F. Wilson (150146)
- Jana V. Van Vliet-Ostaptchouk (4429702)
- Jarmo Virtamo (57860)
- Jeanette Erdmann (44256)
- Jeffrey R. O'Connell (170220)
- Jennie Hui (220409)
- Jennifer G. Sambrook (108247)
- Jennifer Jolley (108251)
- Jennifer L. Bolton (383129)
- Jian Yang (12136)
- Jian'an Luan (2145)
- Jianxin Shi (90453)
- Jing Hua Zhao (73808)
- Joel N. Hirschhorn (131545)
- Johan G. Eriksson (150122)
- Johanna Kuusisto (197767)
- John P. Beilby (418999)
- John W. G. Yarnell (95276)
- Jon P. Krohn (418986)
- Jonathan Tyrer (89946)
- Joseph Hung (418994)
- Joshua C. Randall (145712)
- Josine L. Min (181837)
- Jouke-Jan Hottenga (75574)
- Jouko Saramies (392555)
- Juha Sinisalo (418995)
- Kaarel KrjutĂ ÂĄkov (419002)
- Karen L. Mohlke (143380)
- Kari E. North (68131)
- Kari Kuulasmaa (62541)
- Kari Stefansson (26484)
- Karol Estrada (149937)
- Kathleen Stirrups (145729)
- Kati Kristiansson (149853)
- Kay-Tee Khaw (110271)
- Kees G. Hovingh (418998)
- Ken K. Ong (188600)
- Keri L. Monda (198707)
- Kevin B. Jacobs (160321)
- Krista Fischer (45881)
- Kristian Hveem (189996)
- Kristina Eisinger (418989)
- L. Adrienne Cupples (113601)
- Lambertus A. Kiemeney (160926)
- Lars Lind (88400)
- Leif C. Groop (198713)
- Liming Liang (69800)
- Lindsay L. Waite (392538)
- Lori L. Bonnycastle (262574)
- Lu Qi (160573)
- Lyle J. Palmer (95287)
- Lynda M. Rose (225264)
- M. Carola Zillikens (152896)
- Marcus E. Kleber (106276)
- Maria Dimitriou (160853)
- Maris Teder-Laving (418990)
- Marja-Liisa Lokki (156903)
- Marjo-Riitta Jarvelin (110290)
- Mark I. McCarthy (145748)
- Mark J. Caulfield (238657)
- Markku Laakso (197777)
- Markus M. Nöthen (160934)
- Markus Perola (62544)
- Martin den Heijer (24963)
- Martin Farrall (62715)
- Martina MĂŒller-Nurasyid (193464)
- Mary F. Feitosa (198679)
- Massimo Mangino (87550)
- Matti Uusitupa (89892)
- Mattias Lorentzon (121092)
- Meena Kumari (95278)
- Melanie M. Van der Klauw (5655160)
- Michael A. Province (53600)
- Michael Boehnke (145750)
- Mika Kivimaki (2222011)
- Mustafa Atalay (198682)
- Najaf Amin (114329)
- Nancy L. Heard-Costa (262573)
- Nancy L. Pedersen (123123)
- Narisu Narisu (262622)
- Nicholas G. Martin (113568)
- Nicholas J. Wareham (110277)
- Niina Eklund (149841)
- Nilesh J. Samani (60118)
- Olli Raitakari (144269)
- Pablo V. Gejman (171372)
- Panos Deloukas (21564)
- Patricia B. Munroe (145744)
- Patrik K. E. Magnusson (123143)
- Paul M. Ridker (191917)
- Paul W. Franks (136032)
- Per Hall (23544)
- Peter E. H. Schwarz (261982)
- Peter Kovacs (103720)
- Peter P. Pramstaller (150111)
- Peter S. Chines (145692)
- Philippe Froguel (2247)
- Pim van der Harst (65060)
- Raimund Erbel (49439)
- Rainer Rauramaa (211915)
- Reedik MĂ€gi (667294)
- Robert Kaplan (419010)
- Rona J. Strawbridge (419006)
- Ross M. Fraser (419001)
- Ruth J. F. Loos (110224)
- Sabrina Bauer (418987)
- Sailaja Vedantam (131467)
- Samuli Ripatti (144251)
- Sarah E. Medland (127141)
- Sarah Edkins (203067)
- Sekar Kathiresan (60585)
- Shengxu Li (180928)
- Sirkka M. Keinanen-Kiukaanniemi (5655163)
- Sonali Pechlivanis (282952)
- Sonja I. Berndt (202053)
- Stavroula Kanoni (160847)
- Stefan Gustafsson (418983)
- Stefan R. Bornstein (114705)
- Stephan J. L. Bakker (111215)
- Stephen J. Chanock (14311)
- Steve E. Humphries (142616)
- Susanne Moebus (15191)
- Talin Haritunians (262584)
- Tamara B. Harris (110195)
- Teresa Ferreira (418982)
- Terho LehtimÀki (49739)
- Themistocles L. Assimes (111675)
- Thomas Illig (44906)
- Thomas Person (418985)
- Thomas W. Winkler (174716)
- Tim D. Spector (108990)
- Timo A. Lakka (198694)
- Timo E. Saaristo (419004)
- Timothy Frayling (419009)
- Toby Johnson (43283)
- Tom Wilsgaard (321883)
- Tove Fall (201258)
- Tsegaselassie Workalemahu (315947)
- Tuomas O. KilpelÀinen (145704)
- TÔnu Esko (102379)
- Ulf de Faire (256395)
- Ulf Gyllensten (13773)
- Unnur Thorsteinsdottir (49155)
- Valgerdur Steinthorsdottir (160577)
- Veikko Salomaa (62543)
- Wendy L. McArdle (110155)
- Winfried MĂ€rz (106288)
- Wolfgang Koenig (26222)
- Yii-Der Ida Chen (113593)
- Zhaoming Wang (50224)
- ZoltĂĄn Kutalik (174641)
- Ă sa Johansson (84687)
- Publication venue
- Publication date
- Field of study
a<p>Trait and sex for which the SNP was selected;</p>b<p>Gene labels state the nearest gene or the gene as published previously; details on all genes near the association signal can be found in the <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003500#pgen.1003500.s002" target="_blank">Figure S2</a>;</p>c<p>One-sided P-Values.</p>d<p>larger sample size due to one additional study that did not have hip circumference, and therefore could not contribute to WHRadjBMI.</p>e<p>smaller sample size as this SNP was not on Metabochip.</p><p>Shown are the seven SNPs with significant (at 5% false discovery rate) sex difference in the follow-up data. These seven SNPs exhibit genome-wide significant association in women (joint discovery and follow-up <i>P_women</i><5Ă10â8) and only two of these show nominally significant association in men (joint <i>P_men</i><0.05). The three loci MAP3K1, HSD17B4, and PPARG are shown here for the first time for their anthropometric trait association as well as for sex-difference.</p
Genome-wide scan for sex-specific genome-wide association highlights numerous loci.
- Author
- Adam E. Locke (418984)
- Alan R. Shuldiner (110828)
- Albert Hofman (107303)
- Albert Vernon Smith (6608)
- Aldi T. Kraja (418991)
- Alexander Teumer (112757)
- Alistair S. Hall (87549)
- Amy J. Swift (262632)
- Amélie Bonnefond (179465)
- Anders Hamsten (62728)
- Andre Scherag (5655157)
- Andrea Ganna (419008)
- Andrea Maschio (186176)
- Andres Metspalu (61760)
- Andrew A. Hicks (149966)
- Andrew David Morris (419005)
- Andrew R. Wood (149984)
- Andrew Wong (256256)
- André G. Uitterlinden (2213413)
- Anke Tönjes (103703)
- Anna-Liisa Hartikainen (110272)
- Anne U. Jackson (145702)
- Annette Peters (62601)
- Antigone S. Dimas (170915)
- Antony Paul Attwood (418993)
- Antti Jula (37961)
- Anuj Goel (258576)
- Aroon Hingorani (256127)
- Barbara Thorand (44903)
- Ben A. Oostra (122789)
- Bernhard O. Boehm (203595)
- Bernhard R. Winkelmann (237022)
- Brenda Penninx (202064)
- Bruna Gigante (256392)
- Carlo Rivolta (121162)
- Carlos Iribarren (418997)
- Carolina Medina-Gomez (152852)
- Caroline Hayward (149856)
- Caroline S. Fox (110474)
- Cecilia M. Lindgren (145706)
- Chris Power (198703)
- Christa Buechler (418988)
- Christian Gieger (87555)
- Christian Hengstenberg (44258)
- Christina Loley (418992)
- Claes Ohlsson (1924)
- Claudia Lamina (87552)
- Claudia Langenberg (160616)
- Colin N. A. Palmer (157488)
- Cornelia M. van Duijn (103685)
- Cristina Barlassina (136962)
- Damien C. Croteau-Chonka (392540)
- Daniel I. Chasman (120866)
- David Hunter (273536)
- David P. Strachan (110302)
- David Schlessinger (2399)
- Deborah J. Clegg (179176)
- Denise Anderson (125432)
- Devin Absher (217357)
- Diana Kuh (188923)
- Dmitry Shungin (198691)
- Dominique Arveiler (147942)
- Dorret I. Boomsma (109746)
- Elena Tremoli (74641)
- Elina Hyppönen (163747)
- Elizabeth K. Speliotes (145716)
- Emil Rehnberg (223827)
- Emmanouil T. Dermitzakis (120302)
- Erik Ingelsson (232651)
- Eva Albrecht (174584)
- Evelin Mihailov (419003)
- Felix R. Day (418981)
- Fernando Rivadeneira (61551)
- Francis S. Collins (82181)
- Fredrik Karpe (61681)
- Gabrielle Boucher (215508)
- Genovefa Kolovou (419007)
- George Dedoussis (160919)
- George Nicholson (106301)
- Gerjan Navis (111256)
- Gerry Fowkes (38654)
- Giancarlo Cesana (238596)
- Gonçalo R. Abecasis (36598)
- Grant W. Montgomery (131518)
- Gudmar Thorleifsson (156887)
- Guo Li (174860)
- Göran Hallmans (147486)
- H. Erich Wichmann (202082)
- Hanneke Basart (183445)
- Harald Grallert (72666)
- Harold Snieder (103613)
- Harry Campbell (30339)
- Heikki Huikuri (418996)
- Hendrik Sager (419000)
- Henrik Grönberg (122512)
- Henry Völzke (64286)
- Heribert Schunkert (44257)
- Iain Mathieson (113513)
- Ida Surakka (120325)
- Igor Rudan (150101)
- Ilja M. Nolte (238629)
- Inga Prokopenko (43252)
- Inger NjĂžlstad (211908)
- Ingrid B. Borecki (113678)
- InĂȘs Barroso (2144)
- Irene Mateo Leach (128869)
- Iris M. Heid (87553)
- Jaakko Kaprio (43154)
- Jaakko Tuomilehto (65635)
- Jaana Lindström (263654)
- Jackie F. Price (309412)
- Jacques S. Beckmann (149297)
- James F. Wilson (150146)
- Jana V. Van Vliet-Ostaptchouk (4429702)
- Jarmo Virtamo (57860)
- Jeanette Erdmann (44256)
- Jeffrey R. O'Connell (170220)
- Jennie Hui (220409)
- Jennifer G. Sambrook (108247)
- Jennifer Jolley (108251)
- Jennifer L. Bolton (383129)
- Jian Yang (12136)
- Jian'an Luan (2145)
- Jianxin Shi (90453)
- Jing Hua Zhao (73808)
- Joel N. Hirschhorn (131545)
- Johan G. Eriksson (150122)
- Johanna Kuusisto (197767)
- John P. Beilby (418999)
- John W. G. Yarnell (95276)
- Jon P. Krohn (418986)
- Jonathan Tyrer (89946)
- Joseph Hung (418994)
- Joshua C. Randall (145712)
- Josine L. Min (181837)
- Jouke-Jan Hottenga (75574)
- Jouko Saramies (392555)
- Juha Sinisalo (418995)
- Kaarel KrjutĂ ÂĄkov (419002)
- Karen L. Mohlke (143380)
- Kari E. North (68131)
- Kari Kuulasmaa (62541)
- Kari Stefansson (26484)
- Karol Estrada (149937)
- Kathleen Stirrups (145729)
- Kati Kristiansson (149853)
- Kay-Tee Khaw (110271)
- Kees G. Hovingh (418998)
- Ken K. Ong (188600)
- Keri L. Monda (198707)
- Kevin B. Jacobs (160321)
- Krista Fischer (45881)
- Kristian Hveem (189996)
- Kristina Eisinger (418989)
- L. Adrienne Cupples (113601)
- Lambertus A. Kiemeney (160926)
- Lars Lind (88400)
- Leif C. Groop (198713)
- Liming Liang (69800)
- Lindsay L. Waite (392538)
- Lori L. Bonnycastle (262574)
- Lu Qi (160573)
- Lyle J. Palmer (95287)
- Lynda M. Rose (225264)
- M. Carola Zillikens (152896)
- Marcus E. Kleber (106276)
- Maria Dimitriou (160853)
- Maris Teder-Laving (418990)
- Marja-Liisa Lokki (156903)
- Marjo-Riitta Jarvelin (110290)
- Mark I. McCarthy (145748)
- Mark J. Caulfield (238657)
- Markku Laakso (197777)
- Markus M. Nöthen (160934)
- Markus Perola (62544)
- Martin den Heijer (24963)
- Martin Farrall (62715)
- Martina MĂŒller-Nurasyid (193464)
- Mary F. Feitosa (198679)
- Massimo Mangino (87550)
- Matti Uusitupa (89892)
- Mattias Lorentzon (121092)
- Meena Kumari (95278)
- Melanie M. Van der Klauw (5655160)
- Michael A. Province (53600)
- Michael Boehnke (145750)
- Mika Kivimaki (2222011)
- Mustafa Atalay (198682)
- Najaf Amin (114329)
- Nancy L. Heard-Costa (262573)
- Nancy L. Pedersen (123123)
- Narisu Narisu (262622)
- Nicholas G. Martin (113568)
- Nicholas J. Wareham (110277)
- Niina Eklund (149841)
- Nilesh J. Samani (60118)
- Olli Raitakari (144269)
- Pablo V. Gejman (171372)
- Panos Deloukas (21564)
- Patricia B. Munroe (145744)
- Patrik K. E. Magnusson (123143)
- Paul M. Ridker (191917)
- Paul W. Franks (136032)
- Per Hall (23544)
- Peter E. H. Schwarz (261982)
- Peter Kovacs (103720)
- Peter P. Pramstaller (150111)
- Peter S. Chines (145692)
- Philippe Froguel (2247)
- Pim van der Harst (65060)
- Raimund Erbel (49439)
- Rainer Rauramaa (211915)
- Reedik MĂ€gi (667294)
- Robert Kaplan (419010)
- Rona J. Strawbridge (419006)
- Ross M. Fraser (419001)
- Ruth J. F. Loos (110224)
- Sabrina Bauer (418987)
- Sailaja Vedantam (131467)
- Samuli Ripatti (144251)
- Sarah E. Medland (127141)
- Sarah Edkins (203067)
- Sekar Kathiresan (60585)
- Shengxu Li (180928)
- Sirkka M. Keinanen-Kiukaanniemi (5655163)
- Sonali Pechlivanis (282952)
- Sonja I. Berndt (202053)
- Stavroula Kanoni (160847)
- Stefan Gustafsson (418983)
- Stefan R. Bornstein (114705)
- Stephan J. L. Bakker (111215)
- Stephen J. Chanock (14311)
- Steve E. Humphries (142616)
- Susanne Moebus (15191)
- Talin Haritunians (262584)
- Tamara B. Harris (110195)
- Teresa Ferreira (418982)
- Terho LehtimÀki (49739)
- Themistocles L. Assimes (111675)
- Thomas Illig (44906)
- Thomas Person (418985)
- Thomas W. Winkler (174716)
- Tim D. Spector (108990)
- Timo A. Lakka (198694)
- Timo E. Saaristo (419004)
- Timothy Frayling (419009)
- Toby Johnson (43283)
- Tom Wilsgaard (321883)
- Tove Fall (201258)
- Tsegaselassie Workalemahu (315947)
- Tuomas O. KilpelÀinen (145704)
- TÔnu Esko (102379)
- Ulf de Faire (256395)
- Ulf Gyllensten (13773)
- Unnur Thorsteinsdottir (49155)
- Valgerdur Steinthorsdottir (160577)
- Veikko Salomaa (62543)
- Wendy L. McArdle (110155)
- Winfried MĂ€rz (106288)
- Wolfgang Koenig (26222)
- Yii-Der Ida Chen (113593)
- Zhaoming Wang (50224)
- ZoltĂĄn Kutalik (174641)
- Ă sa Johansson (84687)
- Publication venue
- Publication date
- Field of study
<p>(a) Manhattan plot showing the men-specific (upward, up to 60,586 men) and women-specific (downward, up to 73,137 women) association P-values from the discovery with the 619 selected loci colored by the phenotype for which the locus was selected; (b) QQ-plot showing the sex-specific association P-values as observed against those expected under the null overall phenotypes (black) and for each phenotypes separately (colored).</p
Identification of four independent LD blocks in the 8p23.1 region <i>(~3</i>.<i>3 MBs</i>).
- Author
- Adolfo Correa (610800)
- Alan B. Zonderman (178692)
- Alanna C. Morrison (110248)
- Albert V. Smith (103644)
- Albertine J. Oldehinkel (306724)
- Aldi T. Kraja (418991)
- Alena StanÄĂĄkovĂĄ (197764)
- Alexandre C. Pereira (232570)
- Alisa K. Manning (110227)
- Amy R. Bentley (110243)
- Ananda R. Wickremasinghe (590600)
- Andrea R. V. R. Horimoto (5410790)
- Andres Metspalu (61760)
- André G. Uitterlinden (2213413)
- Anne U. Jackson (145702)
- Annette Peters (62601)
- Antonietta Robino (149863)
- Anuj Goel (258576)
- Anuradhani Kasturiratne (269543)
- Aravinda Chakravarti (77021)
- Archie Campbell (669891)
- Bamidele O. Tayo (164136)
- Barbara V. Howard (215615)
- Barry I. Freedman (120811)
- Benjamin Lehne (215790)
- Bernardo L. Horta (359965)
- Brenda W. J. H. Penninx (122779)
- Brigitte KĂŒhnel (3342752)
- Bruce M. Psaty (103721)
- Bruna Gigante (256392)
- C. Charles Gu (102155)
- Caizheng Yu (5410802)
- Carl D. Langefeld (120828)
- Caroline Hayward (149856)
- Carsten O. Schmidt (399391)
- Cathy C. Laurie (110245)
- Changwei Li (525465)
- Charles B. Eaton (169219)
- Charles Kooperberg (18693)
- Charles N. Rotimi (137216)
- Chew-Kiat Heng (429539)
- Chiea Chuen Khor (306345)
- Ching-Yu Cheng (159319)
- Christian Gieger (87555)
- Christine Williams (2486536)
- Christopher P. Nelson (145678)
- Chuan Gao (38049)
- Claude Bouchard (111107)
- Claudia Langenberg (160616)
- Colin A. McKenzie (230488)
- Colleen M. Sitlani (543237)
- Cora E. Lewis (102128)
- Cornelia M. van Duijn (103685)
- Dabeeru C. Rao (540945)
- Dan E. Arking (143354)
- Daniel I. Chasman (120866)
- Daniel Levy (51573)
- David J. Porteous (107720)
- David R. Weir (3944540)
- Dennis O. Mook-Kanamori (148319)
- Diane M. Becker (113669)
- Dina Vojinovic (5410805)
- Donald W. Bowden (120806)
- Dongfeng Gu (216367)
- E Shyong Tai (4785447)
- Eric Boerwinkle (36288)
- Erin B. Ware (741907)
- Ervin R. Fox (230392)
- Evangelos Evangelou (64006)
- Fang-Chi Hsu (73595)
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<p>Identification of four independent LD blocks in the 8p23.1 region <i>(~3</i>.<i>3 MBs</i>).</p
Overview of design and findings.
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<p>Among the 7 identified loci, we defined those close to (<1 cM) published hits <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003500#pgen.1003500-LangoAllen1" target="_blank">[25]</a>, <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003500#pgen.1003500-Speliotes1" target="_blank">[29]</a>, <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003500#pgen.1003500-Heid1" target="_blank">[31]</a> as <i>near published hit</i>s and <i>novel</i> otherwise. Novel loci with sex-combined discovery P-value<5.8Ă10<sup>â5</sup>, which is the P-value cut-off corresponding to 5% FDR, were declared as loci that <i>could have been discovered also with sex-combined analysis</i>, and otherwise that these <i>would have been missed without the sex-stratified analyses</i>. FDRâ=âfalse discovery rate.</p