Race-specific hazard ratios (HR) for venous thromboembolism (VTE) in relation to quartiles of the 273-variant and the 5-variant genetic risk scores (GRS) examined jointly in model 1, ARIC*, 1987–2019.

(DOCX)</p

Cumulative incidence of venous thromboembolism (VTE) by quartiles of (a) the 273-variant genetic risk score (GRS) or (b) the 5-variant GRS, ARIC, 1987–2019.

(DOCX)</p

Incidence rates and race-specific hazard ratios (HR) for venous thromboembolism (VTE) in relation to quartiles of the 273-variant genetic risk score (GRS), ARIC*, 1987–2019.

Incidence rates and race-specific hazard ratios (HR) for venous thromboembolism (VTE) in relation to quartiles of the 273-variant genetic risk score (GRS), ARIC*, 1987–2019.</p

S1 Table -

(XLSX)</p

Incidence rates and race-specific hazard ratios (HR) for venous thromboembolism (VTE) in relation to quartiles of the 5-variant genetic risk score (GRS), ARIC*, 1987–2019.

Incidence rates and race-specific hazard ratios (HR) for venous thromboembolism (VTE) in relation to quartiles of the 5-variant genetic risk score (GRS), ARIC*, 1987–2019.</p

S2 Fig -

(TIFF)</p

S1 Fig -

(TIFF)</p

Race-specific hazard ratios (HR) for venous thromboembolism (VTE) in relation to quartiles of the 273-variant genetic risk score (GRS) versus two supplemental GRSs, ARIC*, 1987–2019.

Race-specific hazard ratios (HR) for venous thromboembolism (VTE) in relation to quartiles of the 273-variant genetic risk score (GRS) versus two supplemental GRSs, ARIC*, 1987–2019.</p

Fig 1 -

Hazard ratios of venous thromboembolism in relation to the 273-variant genetic risk score (GRS) in (a) White participants and (b) Black participants or the 5-Variant GRS in (c) White participants and (d) Black participants, ARIC, 1987–2019. Created using restricted cubic spline model with 3 knots and adjusted for age, sex, and principal components of ancestry. Reference values for the hazard ratios were 20.8 for the 273-variant score and 0.61 for the 5-variant score.</p

Baseline characteristics (mean or percent) of the full cohort compared with the cohort included in the analysis, ARIC, 1987–89.

(DOCX)</p