1,099 research outputs found

    Vasculitis manifested with multiple mass lesions in kidneys, lungs and soft tissue, mimicking malignant tumors

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    We report a case of granulomatosis with polyangiitis (GPA) (Wegner's granulomatosis) who presented with multiple mass lesions in kidneys and lung lobes, as well as neck soft tissue, mimicking malignancies. This 71-year-old woman initially presented with sudden right foot drop, left calf pain and right eye vision loss. She was treated with corticosteroid for the diagnosis of possible temporal arteritis. Months after steroid was tapered to 2 mg per day, she developed increasing fatigue, weight loss, and shortness of breath. CT scan showed lung mass lesions in left upper lobe (3.8 × 2.4 cm), right mid lung with pleural extension (3.4 × 3.3 cm), and right lower lobe (1.1 × 1.0 cm); right neck (3.3 × 2.6 cm), right kidney (2.3 × 1.8 cm) and left kidney (2.0 × 1.6 cm). Right quadriceps muscle biopsy shows focal granulomatous inflammation. Lung biopsy showed necrotizing and poorly formed granulomatous inflammation. Biopsies of kidney mass lesions showed necrotizing and non-necrotizing granulomatous inflammation. No crescentic or necrotizing glomerular lesions were observed in the total 40 sampled glomeruli. No malignancy was identified in any of the biopsies. Her c-ANCA was found to be positive and PR3-ANCA antibody was 6.88 U/ml (normal 0–0.90 U/ml). She was diagnosed with granulomatosis with polyangiitis and treated with high dose corticosteroid and rituximab. Eight months later, follow-up showed resolved mass lesions by chest X-ray and CT and stable renal function. The case highlights the atypical clinical presentation of vasculitis and the significance of considering this possibility in differential diagnosis when confronting mass lesions present in multiple organ systems. Biopsy is critical for the correct diagnosis to initiate timely and appropriate treatment, and also important to avoid unnecessary surgical resection

    A Quality Improvement Checklist for the Perioperative Management of Surgical Patients with Opioid Addiction on Buprenorphine

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    Background: Buprenorphine is a semisynthetic opioid agonist-antagonist that displays antagonism at kappa receptors and partial agonist at mu receptors. Buprenorphine has the unfortunate effect of interfering with the actions of opioids administered for medical indications. When patients on buprenorphine present for surgery or procedures requiring anesthesia, it can become a substantial challenge. Currently, there are no guidelines or checklists that would help the anesthetist to provide adequate pain management for the OUD patient population. Objectives: (1) Understand the perioperative management of patients with opioid addiction on buprenorphine. (2) Demonstrate increased knowledge and confidence in understanding the challenges, pharmacokinetics, and pharmacodynamics of managing a patient on buprenorphine. (3) Discuss and manage perioperative interventions of patients taking buprenorphine with opioid addiction. Methodology: The primary methodology of the proposed project was to administer an online Zoom educational module to providers that focus on the perioperative management of patients with OUD who take buprenorphine. The project was implemented by conducting an online pre-assessment test, zoom educational module, and a post-assessment test that assessed the anesthesia providers\u27 knowledge about managing a patient with OUD on buprenorphine during the perioperative period. Pre-assessment and post-assessment testing were used to measure the effects of the educational module. Statistical analysis was applied to assess the effectiveness of the educational module. Results: There was a total of five Certified Registered Nurse Anesthetists (CRNAs) that participated in the quality improvement project. The results reflected an improvement in knowledge based on the pre-test and post-test scores. Knowledge showed an average gain of (25%). In addition, the post-test demonstrated that participants are most likely (n=4, 80%) or somewhat likely (n=2, 20%) to implement a perioperative checklist for surgical patients with opioid addiction taking buprenorphine. Conclusion: An evidence-based educational module determined an increase in participants\u27 knowledge of managing surgical patients with OUD taking buprenorphine during the perioperative period. There is no consensus on the management of buprenorphine; however, the recommendation is to continue buprenorphine during the perioperative period

    Modeling the Effects of Drug Binding on the Dynamic Instability of Microtubules

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    We propose a stochastic model that accounts for the growth, catastrophe and rescue processes of steady state microtubules assembled from MAP-free tubulin. Both experimentally and theoretically we study the perturbation of microtubule dynamic instability by S-methyl-D-DM1, a synthetic derivative of the microtubule-targeted agent maytansine and a potential anticancer agent. We find that to be an effective suppressor of microtubule dynamics a drug must primarily suppress the loss of GDP tubulin from the microtubule tip.Comment: 17 pages, 11 figures, to appear in Phys. Bio

    The Ursinus Weekly, October 23, 1950

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    Bears trounce Garnet for first victory, 35-14 • Campus group will sponsor political rally • IRC plans events for near future • YM-YW commission to discuss president\u27s anti-red bill veto • Future teachers meet • Czech tells of red-occupied homeland to Bomberger Hall Forum audience • Group to organize unit of Red Cross • Senior class to sponsor masquerade Saturday • Clark, Deitch, Friedlin, and Maliken head freshman class • Congressman addresses Founders Day assembly • Curtain Club picks three members of Angel Street cast • Customs declared over by student councils • Phantasy reported in full rehearsal • Hundred and fifty girls attend annual junior-frosh breakfast • Editorial: Price of victory; Let\u27s send that TV set • Athletes keep new trainer busy • Scribe pens WSGA notes • Reporter ferrets facts about South, where life is chaotic but pleasant • MSGA discusses inter-dorm council, concession, and announcement limits • Delta Pi Sigma frat emerges as recognized social group • Bruins to clash with Seahawks at Staten Island • JV hockey squad whips Albright 11-0 • Booters tie alumni on Old Timers Day after mid-week 4-2 loss to Lafayette • Hockey team opens with 2-1 win over East Stroudsburg • Swarthmore bows 35-14 in first victory for Bears • Library to get additional tier of book racks • McPherson reigns as harvest queen at Varsity Club ball • Senior quartet makes debut on televisionhttps://digitalcommons.ursinus.edu/weekly/1549/thumbnail.jp

    The Ursinus Weekly, February 19, 1951

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    MSGA accepts modifications to Soph rules • Curtain Club to present one-act play, Feb. 27 • Dr. Krishnayya gives Indian position, clarifies Nehru\u27s policies on Red China • Complications feature plot of Speak easy • Ursinus graduate to address Pre-Legal society Tuesday • Thespians to produce Arsenic and Old Lace • All-Ursinus cast to appear March 17 on Stars in Your Eyes television show • Frosberg and Brownback named co-editors of Alumni Journal • Chi Alpha plans seminary visit, discusses ministerial course • Juniors pick Fuhrman • Campus displays colors for annual ceremony • Dean\u27s Office lists enrollment at 771; 19 enter this term • Lorelei lures males, wrecks egos with curious corsages • French Club sponsors mid-week Mardi Gras • Larry Livingston, chemist, to present lecture on Progress in Better Living • Editorial: Brotherhood, modern style; Lenten thoughts • English office, place of cheerful disorder, is the ultimate authority for all knowledge • Soft music provides impetus for study in relaxed atmosphere of record room • Turnabout: Professors divulge trade secrets, disclose examples of Ursinus student boners • If you tought you saw a puddie-cat in Pfahler, you did • Bears toppled from loop lead by Haverford five • Girls vying for Badminton berths • Swarthmore hands Ursinus Mermaids first defeat, 42-15 • Blue Hens triumph over Bears 23-11; Helfferich victor • Shreiner-Baird squad leads in intramural competition • Garnet cops 63-49 win over staggering Grizzlies • Brodbeck fives top intramural circuit • Should America\u27s women be drafted? • Chesterfield announces names of photography contest winners • IRC hears views of State Department as Miller reports off-record session • Spanish Club studies music • Board member to show film depicting Amish life April 26https://digitalcommons.ursinus.edu/weekly/1559/thumbnail.jp

    The Ursinus Weekly, February 12, 1951

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    New high set by B-list group as 106 qualify • Y schedules chats, conducts retreat • Paynter-Keller production scores hit in Curtain Club group presentation • Play contest in progress; May Day heads named • Alumna to speak at girls\u27 Color Day program Thursday • Eight enter Ursinus for Spring term • Forum to feature Indian editor at next session • Speak Easy title of Ruby show • TV auditions slated • 3 graduate school test dates released • Ursinus to enter competition in intercollegiate bridge • Dr. Miller to give IRC summary of Department of State conferences attended in recent weeks • Washington trip planned by PAC • Meistersingers give concert • Editorial: Attend forums? • Senior class discusses Ruby and after-game record dance • Red Cross to organize • Juniors discuss bands • French Club to present dance Wednesday night in music studio • Thespians to discuss play • Dictionary of Folklore and Legend includes work of Dr. Phillips on Pennsylvania Dutch • Behind-scenes Dean handles transcripts, records dating from 1873, in routine work • Men reveal resignation toward draft situation • Alumnae back and Duryea\u27s got \u27em; Grads return in role of preceptresses • Coach Seeders drives Bruins toward coveted Middle Atlantic championship • Grizzlies win and lose in non-league contests • Bears edge Blue Hens for loop lead, 62-60 • Mermaids triumph over Drexel, 35-22 • Belles bag first over Bryn Mawr • Brodbeck I & II, Stine lead • Dr. Baker chooses poetry of A. E. Housman for readinghttps://digitalcommons.ursinus.edu/weekly/1558/thumbnail.jp

    The Ursinus Weekly, February 12, 1951

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    New high set by B-list group as 106 qualify • Y schedules chats, conducts retreat • Paynter-Keller production scores hit in Curtain Club group presentation • Play contest in progress; May Day heads named • Alumna to speak at girls\u27 Color Day program Thursday • Eight enter Ursinus for Spring term • Forum to feature Indian editor at next session • Speak Easy title of Ruby show • TV auditions slated • 3 graduate school test dates released • Ursinus to enter competition in intercollegiate bridge • Dr. Miller to give IRC summary of Department of State conferences attended in recent weeks • Washington trip planned by PAC • Meistersingers give concert • Editorial: Attend forums? • Senior class discusses Ruby and after-game record dance • Red Cross to organize • Juniors discuss bands • French Club to present dance Wednesday night in music studio • Thespians to discuss play • Dictionary of Folklore and Legend includes work of Dr. Phillips on Pennsylvania Dutch • Behind-scenes Dean handles transcripts, records dating from 1873, in routine work • Men reveal resignation toward draft situation • Alumnae back and Duryea\u27s got \u27em; Grads return in role of preceptresses • Coach Seeders drives Bruins toward coveted Middle Atlantic championship • Grizzlies win and lose in non-league contests • Bears edge Blue Hens for loop lead, 62-60 • Mermaids triumph over Drexel, 35-22 • Belles bag first over Bryn Mawr • Brodbeck I & II, Stine lead • Dr. Baker chooses poetry of A. E. Housman for readinghttps://digitalcommons.ursinus.edu/weekly/1558/thumbnail.jp
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