1 research outputs found
Synthesis and Biological Evaluation of a Biotinylated Paclitaxel with an Extra-Long Chain Spacer Arm
A biotinylated paclitaxel derivative with an extra-long
chain (LC-LC-biotin)
spacer arm was synthesized using an improved synthetic reaction sequence.
The biotinylated paclitaxel analogue retained excellent microtubule
stabilizing activity in vitro. Furthermore, it was shown that this
analogue can simultaneously engage streptavidin and the binding site
on microtubules, making it suitable for localization studies or for
the attachment of paclitaxel to solid substrates via a streptavidin
linkage