Infection (grey) and disease (red) attack rates amongst household contacts of index cases for (A) case characteristics and (B) contact characteristics.

<p>Infection (grey) and disease (red) attack rates amongst household contacts of index cases for (A) case characteristics and (B) contact characteristics.</p

Infection and disease households with a rotavirus index case.

<p>Each line represents infection and disease events in one household. Index cases are plotted in black (n = 39). Other cases of rotavirus gastroenteritis in the household are plotted in red and are plotted on the time axis in terms of time of onset relative to time of onset of the index case. Household contacts with asymptomatic infection are plotted in blue (off the time scale, since we cannot know at what time they become infected) and contacts remaining uninfected are plotted in grey. The size of the points are relative to the number of individuals with a given outcome; for reference the size of the index cases (black dots) represents a single individual.</p

Infection attack rates amongst household contacts by their own characteristics and index case characteristics.

<p>Odds ratios, 95% confidence intervals and Wald-test p values are given for (a) univariate models, multivariate models of (b) other case <i>or</i> contact characteristics and (c) other case <i>and</i> contact characteristics.</p

Calendar month distribution of index cases (n = 39) diarrhea controls (n = 40) and healthy controls (n = 40).

<p>Calendar month distribution of index cases (n = 39) diarrhea controls (n = 40) and healthy controls (n = 40).</p

Genotype (G- and P-type) profiles of infections amongst rotavirus index cases and household contacts.

<p>The first 2 columns represent the G and P types (respectively) of the typeable index cases (n = 35) and, with each typeable household contact (n = 57) shown to the right of the index case. Single G and P-tpye infections are color-coded; mixed infections are in black and un-typeable G- or P-types are in grey.</p

Disease attack rates^* amongst household contacts by their own characteristics and index case characteristics.

*<p>There was not sufficient power to fit regression model when using the definition of disease of symptomatic and RT-qPCR positive, as only 8 contacts met this definition. However, the simple frequency tabulations with this outcome were consistent with the disease (regardless of test result) outcome analysis. Attack rates were higher from children who were younger (24% (6/25) from children <18 months compared to 2% (2/106) from children ≥18 months), had multiple episodes of vomiting (15% (8/82) compared to 0% from children with 1 or no episodes of vomiting (0/79)) and amongst contacts aged less than 10 years (27% (7/26) compared to contacts aged 10 years or older (0%; 0/91)).</p><p>Odds ratios, 95% confidence intervals and Wald-test p values are given for (a) univariate models, multivariate models of (b) other case <i>or</i> contact characteristics and (c) other case <i>and</i> contact characteristics.</p