83 research outputs found
Human factors in forensic science: The cognitive mechanisms that underlie forensic feature-comparison expertise
After a decade of critique from leading scientific bodies, forensic science research is at a crossroads. Whilst emerging research has shown that some forensic feature-comparison disciplines are not foundationally valid, others are moving towards establishing reliability and validity. Forensic examiners in fingerprint, face and handwriting comparison disciplines have skills and knowledge that distinguish them from novices. Yet our understanding of the basis of this expertise is only beginning to emerge. In this paper, we review evidence on the psychological mechanisms contributing to forensic feature-comparison expertise, with a focus on one mechanism: statistical learning, or the ability to learn how often things occur in the environment. Research is beginning to emphasise the importance of statistical learning in forensic feature-comparison expertise. Ultimately, this research and broader cognitive science research has an important role to play in informing the development of training programs and selection tools for forensic feature-comparison examiners
Inhibition of Post-Synaptic Kv7/KCNQ/M Channels Facilitates Long-Term Potentiation in the Hippocampus
Activation of muscarinic acetylcholine receptors (mAChR) facilitates the induction of synaptic plasticity and enhances cognitive function. In the hippocampus, M1 mAChR on CA1 pyramidal cells inhibit both small conductance Ca2+-activated KCa2 potassium channels and voltage-activated Kv7 potassium channels. Inhibition of KCa2 channels facilitates long-term potentiation (LTP) by enhancing Ca2+calcium influx through postsynaptic NMDA receptors (NMDAR). Inhibition of Kv7 channels is also reported to facilitate LTP but the mechanism of action is unclear. Here, we show that inhibition of Kv7 channels with XE-991 facilitated LTP induced by theta burst pairing at Schaffer collateral commissural synapses in rat hippocampal slices. Similarly, negating Kv7 channel conductance using dynamic clamp methodologies also facilitated LTP. Negation of Kv7 channels by XE-991 or dynamic clamp did not enhance synaptic NMDAR activation in response to theta burst synaptic stimulation. Instead, Kv7 channel inhibition increased the amplitude and duration of the after-depolarisation following a burst of action potentials. Furthermore, the effects of XE-991 were reversed by re-introducing a Kv7-like conductance with dynamic clamp. These data reveal that Kv7 channel inhibition promotes NMDAR opening during LTP induction by enhancing depolarisation during and after bursts of postsynaptic action potentials. Thus, during the induction of LTP M1 mAChRs enhance NMDAR opening by two distinct mechanisms namely inhibition of KCa2 and Kv7 channels
Nutritional psychiatry research: an emerging discipline and its intersection with global urbanization, environmental challenges and the evolutionary mismatch
Natural environments, ancestral diets, and microbial ecology: is there a modern âpaleo-deficit disorderâ? Part II
Clear communication through clear purpose: understanding statistical statements made by forensic scientists
Based on a plenary lecture presented at the 50th Anniversary of the Australian Academy of Forensic Sciences Symposium (November 2017) this article reviews the literature relating to the communication of forensic science evidence using statistical statements. Five dimensions of communication are identified: consistency, sensitivity, coherence, ability and orthodoxy. The review also considers the strengths and weaknesses of lay comprehension as well as opportunities for improving understanding through reflection and collaboration
Perception problems of the verbal scale: A reanalysis and application of a membership function approach
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