Comment on “Adjacent segment infection after surgical treatment of spondylodiscitis” by Siam AE et al.

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Recorded displacements in a landslide slope due to regional and teleseismic earthquakes

Regional and teleseismic earthquakes can induce displacements along joints in a landslideinvolved rocky slope in Central Italy. The rarity of these effects is due to specific physical properties of the seismic signals associated with: (i) the energy content, (ii) the distribution of relative energy and peak of ground acceleration related to the ground motion components and (iii) the spectral amplitude distribution in the frequency domain; these properties allow the triggering earthquakes to be distinguished from the others. The observed effects are relevant when compared to the direction of the landslide movement and the dimensions of the involved rock mass volume. The landslide movement is less constrained in the direction parallel to the dip of the slope and the landslide dimensions are associated with characteristic periods that control the landslide deformational response in relation to the spectral content of the ground motion. The earthquake-induced displacements are significant because they have the same order of magnitude as the average annual cumulative displacement based on a decade of strain measurements within the slope

Recent Advances in Pediatric Use of Oral Paracetamol in Fever and Pain Management

Paracetamol is a common analgesic and antipyretic drug for management of fever and mild-to-moderate pain in infants and children, and it is considered as first-line therapy for the treatment of both according to international guidelines and recommendations. The mechanism of action of paracetamol is complex and multifactorial, and several aspects of the pharmacology impact its clinical use, especially in the selection of the correct analgesic and antipyretic dose. A systematic literature search was performed by following procedures for transparent reporting of systematic reviews and meta-analyses. To maximize efficacy and avoid delays in effect, use of the appropriate dose of paracetamol is paramount. Older clinical studies using paracetamol at subtherapeutic doses of ≤10 mg/kg generally show that it is less effective than non-steroidal anti-inflammatory drugs (NSAIDs). However, recent evidence shows that when used at dose of 15 mg/kg for fever and pain management, paracetamol is significantly more effective than placebo, and at least as effective as NSAIDs. Paracetamol 15 mg/kg has a tolerability profile similar to that of placebo and NSAIDs such as ibuprofen and ketoprofen used for short-term treatment of fever. However, when used at repetitive doses for consecutive days, paracetamol shows lower risk of adverse events compared to NSAIDs. Also, unlike NSAIDs, paracetamol is indicated for use in children of all ages. Overall, clinical evidence qualifies paracetamol 15 mg/kg a safe and effective option for treatment of pain and fever in children

第1章 A Review of Theoretical Approches to Governance and Cross-border Governance in the European Union

平成14年度～平成17年度科学研究費補助金(基盤研究 (A))　「国境を越える地域経済ガバナンス・EU諸地域の先行例を中心とした比較研究」 (課題番号 14252007) 研究成果報告書

第14章 イタリアの北東部における産業地区の国際的ガバナンス

平成14年度～平成17年度科学研究費補助金(基盤研究 (A))　「国境を越える地域経済ガバナンス・EU諸地域の先行例を中心とした比較研究」 (課題番号 14252007) 研究成果報告書

第10章 オランダとドイツの国境地域におけるユーロリージョンの歴史と現状

平成14年度～平成17年度科学研究費補助金(基盤研究 (A))　「国境を越える地域経済ガバナンス・EU諸地域の先行例を中心とした比較研究」 (課題番号 14252007) 研究成果報告書