5,313 research outputs found
Recorded displacements in a landslide slope due to regional and teleseismic earthquakes
Regional and teleseismic earthquakes can induce displacements along joints in a landslideinvolved
rocky slope in Central Italy. The rarity of these effects is due to specific physical
properties of the seismic signals associated with: (i) the energy content, (ii) the distribution of
relative energy and peak of ground acceleration related to the ground motion components and
(iii) the spectral amplitude distribution in the frequency domain; these properties allow the
triggering earthquakes to be distinguished from the others. The observed effects are relevant
when compared to the direction of the landslide movement and the dimensions of the involved
rock mass volume. The landslide movement is less constrained in the direction parallel to the
dip of the slope and the landslide dimensions are associated with characteristic periods that
control the landslide deformational response in relation to the spectral content of the ground
motion. The earthquake-induced displacements are significant because they have the same
order of magnitude as the average annual cumulative displacement based on a decade of strain
measurements within the slope
Recent Advances in Pediatric Use of Oral Paracetamol in Fever and Pain Management
Paracetamol is a common analgesic and antipyretic drug for management of fever and mild-to-moderate pain in infants and children, and it is considered as first-line therapy for the treatment of both according to international guidelines and recommendations. The mechanism of action of paracetamol is complex and multifactorial, and several aspects of the pharmacology impact its clinical use, especially in the selection of the correct analgesic and antipyretic dose. A systematic literature search was performed by following procedures for transparent reporting of systematic reviews and meta-analyses. To maximize efficacy and avoid delays in effect, use of the appropriate dose of paracetamol is paramount. Older clinical studies using paracetamol at subtherapeutic doses of ≤10 mg/kg generally show that it is less effective than non-steroidal anti-inflammatory drugs (NSAIDs). However, recent evidence shows that when used at dose of 15 mg/kg for fever and pain management, paracetamol is significantly more effective than placebo, and at least as effective as NSAIDs. Paracetamol 15 mg/kg has a tolerability profile similar to that of placebo and NSAIDs such as ibuprofen and ketoprofen used for short-term treatment of fever. However, when used at repetitive doses for consecutive days, paracetamol shows lower risk of adverse events compared to NSAIDs. Also, unlike NSAIDs, paracetamol is indicated for use in children of all ages. Overall, clinical evidence qualifies paracetamol 15 mg/kg a safe and effective option for treatment of pain and fever in children
Regret-Minimizing Contracts: Agency Under Uncertainty
We study the fundamental problem of designing contracts in principal-agent
problems under uncertainty. Previous works mostly addressed Bayesian settings
in which principal's uncertainty is modeled as a probability distribution over
agent's types. In this paper, we study a setting in which the principal has no
distributional information about agent's type. In particular, in our setting,
the principal only knows some uncertainty set defining possible agent's action
costs. Thus, the principal takes a robust (adversarial) approach by trying to
design contracts which minimize the (additive) regret: the maximum difference
between what the principal could have obtained had them known agent's costs and
what they actually get under the selected contract
第1章 A Review of Theoretical Approches to Governance and Cross-border Governance in the European Union
平成14年度~平成17年度科学研究費補助金(基盤研究 (A)) 「国境を越える地域経済ガバナンス・EU諸地域の先行例を中心とした比較研究」 (課題番号 14252007) 研究成果報告書
第14章 イタリアの北東部における産業地区の国際的ガバナンス
平成14年度~平成17年度科学研究費補助金(基盤研究 (A)) 「国境を越える地域経済ガバナンス・EU諸地域の先行例を中心とした比較研究」 (課題番号 14252007) 研究成果報告書
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