108 research outputs found
Perceived Instability, Pain, and Psychological Factors Predict Function and Disability in Individuals with Chronic Ankle Instability
Context:
Chronic ankle instability (CAI) is associated with residual instability, pain, decreased function, and increased disablement. Injury-related fear has been associated with CAI, although its relationship to other impairments is unclear. The Fear-Avoidance Model is a theoretical framework hypothesizing a relationship between injury-related fear, chronic pain, pain catastrophizing, and disability. It has been useful in understanding fear\u27s influence in other musculoskeletal conditions but has yet to be studied in those with CAI.
Objective:
To explore relationships between instability, pain catastrophizing, injury-related fear, pain, ankle function, and global disability in individuals with CAI.
Design:
Cross-Sectional Study
Setting:
Anonymous online survey
Patients or Other Participants:
A total of 259 people, recruited via e-mail and social media, with a history of ankle sprain completed the survey; of those, 126 participants (age=32.69±4.38, female=84.92%, highly active=73.81%) were identified to have CAI and were included in the analysis.
Main Outcome Measure(s):
Demographics included gender identity, age, and physical activity level. Assessments encompassed the Identification of Functional Ankle Instability (instability), the Pain Catastrophizing Scale (pain catastrophizing), the Tampa Scale of Kinesiophobia-11 (injury-related fear), a numeric pain rating scale and activity-based question (pain presence), the Quick-FAAM (ankle function), and the modified Disablement in the Physically Active Scale (disability). Relationships between variables were explored through correlation and regression analyses.
Results:
After controlling for instability and pain, pain catastrophizing and injury-related fear were significantly related to function and disability ratings in individuals with CAI. Together, the variables predicted 48.7% (P\u3c.001) variance in function and 44.2% (P\u3c.001) variance in disability.
Conclusions:
Greater instability, pain, greater pain catastrophizing, and greater injury-related fear were predictive of decreased function and greater disability in those with CAI. This is consistent with the hypothesized relationships in the Fear-Avoidance Model, although further investigation is needed to determine causality of these factors in the development of CAI
Boundary States and Black Hole Entropy
Black hole entropy is derived from a sum over boundary states. The boundary
states are labeled by energy and momentum surface densities, and parametrized
by the boundary metric. The sum over state labels is expressed as a functional
integral with measure determined by the density of states. The sum over metrics
is expressed as a functional integral with measure determined by the universal
expression for the inverse temperature gradient at the horizon. The analysis
applies to any stationary, nonextreme black hole in any theory of gravitational
and matter fields.Comment: 4 pages, Revte
Semiclassical Mechanics of the Wigner 6j-Symbol
The semiclassical mechanics of the Wigner 6j-symbol is examined from the
standpoint of WKB theory for multidimensional, integrable systems, to explore
the geometrical issues surrounding the Ponzano-Regge formula. The relations
among the methods of Roberts and others for deriving the Ponzano-Regge formula
are discussed, and a new approach, based on the recoupling of four angular
momenta, is presented. A generalization of the Yutsis-type of spin network is
developed for this purpose. Special attention is devoted to symplectic
reduction, the reduced phase space of the 6j-symbol (the 2-sphere of Kapovich
and Millson), and the reduction of Poisson bracket expressions for
semiclassical amplitudes. General principles for the semiclassical study of
arbitrary spin networks are laid down; some of these were used in our recent
derivation of the asymptotic formula for the Wigner 9j-symbol.Comment: 64 pages, 50 figure
Skipper-CCD Sensors for the Oscura Experiment: Requirements and Preliminary Tests
Oscura is a proposed multi-kg skipper-CCD experiment designed for a dark
matter (DM) direct detection search that will reach unprecedented sensitivity
to sub-GeV DM-electron interactions with its 10 kg detector array. Oscura is
planning to operate at SNOLAB with 2070 m overburden, and aims to reach a
background goal of less than one event in each electron bin in the 2-10
electron ionization-signal region for the full 30 kg-year exposure, with a
radiation background rate of 0.01 dru. In order to achieve this goal, Oscura
must address each potential source of background events, including instrumental
backgrounds. In this work, we discuss the main instrumental background sources
and the strategy to control them, establishing a set of constraints on the
sensors' performance parameters. We present results from the tests of the first
fabricated Oscura prototype sensors, evaluate their performance in the context
of the established constraints and estimate the Oscura instrumental background
based on these results
Early Science with the Oscura Integration Test
Oscura is a planned light-dark matter search experiment using Skipper-CCDs
with a total active mass of 10 kg. As part of the detector development, the
collaboration plans to build the Oscura Integration Test (OIT), an engineering
test experiment with 10% of the Oscura's total mass. Here we discuss the early
science opportunities with the OIT to search for millicharged particles (mCPs)
using the NuMI beam at Fermilab. mCPs would be produced at low energies through
photon-mediated processes from decays of scalar, pseudoscalar, and vector
mesons, or direct Drell-Yan productions. Estimates show that the OIT would be a
world-leading probe for low-mass mCPs.Comment: 21 pages, 13 figure
The Neural Basis of Decision-Making and Reward Processing in Adults with Euthymic Bipolar Disorder or Attention-Deficit/Hyperactivity Disorder (ADHD)
Attention-deficit/hyperactivity disorder (ADHD) and bipolar disorder (BD) share DSM-IV criteria in adults and cause problems in decision-making. Nevertheless, no previous report has assessed a decision-making task that includes the examination of the neural correlates of reward and gambling in adults with ADHD and those with BD
Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition
About half of all cancers have somatic integrations of retrotransposons. Here, to characterize their role in oncogenesis, we analyzed the patterns and mechanisms of somatic retrotransposition in 2,954 cancer genomes from 38 histological cancer subtypes within the framework of the Pan-Cancer Analysis of Whole Genomes (PCAWG) project. We identified 19,166 somatically acquired retrotransposition events, which affected 35% of samples and spanned a range of event types. Long interspersed nuclear element (LINE-1; L1 hereafter) insertions emerged as the first most frequent type of somatic structural variation in esophageal adenocarcinoma, and the second most frequent in head-and-neck and colorectal cancers. Aberrant L1 integrations can delete megabase-scale regions of a chromosome, which sometimes leads to the removal of tumor-suppressor genes, and can induce complex translocations and large-scale duplications. Somatic retrotranspositions can also initiate breakage–fusion–bridge cycles, leading to high-level amplification of oncogenes. These observations illuminate a relevant role of L1 retrotransposition in remodeling the cancer genome, with potential implications for the development of human tumors
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