3,513 research outputs found
Selective decay and coherent vortices in two-dimensional incompressible turbulence
Numerical solution of two-dimensional incompressible hydrodynamics shows that states of a near-minimal ratio of enstrophy to energy can be attained in times short compared with the flow decay time, confirming the simplest turbulent selective decay conjecture, and suggesting that coherent vortex structures do not terminate nonlinear processes. After all possible vortex mergers occur, the vorticity attains a particlelike character, suggested by the late-time similarity of the streamlines to Ewald potential contours
Moments of inertia for solids of revolution and variational methods
We present some formulae for the moments of inertia of homogeneous solids of
revolution in terms of the functions that generate the solids. The development
of these expressions exploits the cylindrical symmetry of these objects, and
avoids the explicit use of multiple integration, providing an easy and
pedagogical approach. The explicit use of the functions that generate the solid
gives the possibility of writing the moment of inertia as a functional, which
in turn allows us to utilize the calculus of variations to obtain a new insight
into some properties of this fundamental quantity. In particular, minimization
of moments of inertia under certain restrictions is possible by using
variational methods.Comment: 6 pages, 6 figures, LaTeX2e. Two paragraphs added. Minor typos
corrected. Version to appear in European Journal of Physic
Two-ply channels for faster wicking in paper-based microfluidic devices
This article describes the development of porous two-ply channels for paper-based microfluidic devices that wick fluids significantly faster than conventional, porous, single-ply channels. The two-ply channels were made by stacking two single-ply channels on top of each other and were fabricated entirely out of paper, wax and toner using two commercially available printers, a convection oven and a thermal laminator. The wicking in paper-based channels was studied and modeled using a modified LucasâWashburn equation to account for the effect of evaporation, and a paper-based titration device incorporating two-ply channels was demonstrated
Forced instability of core-annular flow in capillary constrictions
Instability of fluid cylinders and jets, a highly nonlinear hydrodynamic phenomenon, has fascinated researchers for nearly 150 years. A subset of the phenomenon is the core-annular flow, in which a non-wetting core fluid and a surrounding wall-wetting annulus flow through a solid channel. The model, for example, represents the flow of oil in petroleum reservoirs. The flow may be forced to break up when passing through a channelâs constriction. Although it has long been observed that the breakup occurs near the neck of the constriction, the exact conditions for the occurrence of the forced breakup and its dynamic theory have not been understood. Here, we test a simple geometric conjecture that the fluid will always break in the constrictions of all channels with sufficiently long wavelengths, regardless of the fluid properties. We also test a theory of the phenomenon. Four constricted glass tubes were fabricated above and below the critical wavelength required for the fluid disintegration. In a direct laboratory experiment, the breakup occurred according to the conjecture: the fluids were continuous in the shorter tubes but disintegrated in the longer tubes. The evolution of the interface to its pinch-off was recorded using high-speed digital photography. The experimentally observed core-annulus interface profiles agreed well with the theory, although the total durations of the process agreed less satisfactorily. Nonetheless, as the theory predicts, the ratio between the experimental and theoretical times of the breakup process tends to one with decreasing capillary number. The breakup condition and the dynamic theory of fluid disintegration in constricted channels can serve as quantitative models of this important natural and technical phenomenon
Restrictive ID policies: implications for health equity
We wish to thank Synod Community Services for their critical work to develop, support, and implement a local government-issued ID in Washtenaw County, MI. We also thank Yousef Rabhi of the Michigan House of Representatives and Janelle Fa'aola of the Washtenaw ID Task Force, Lawrence Kestenbaum of the Washtenaw County Clerk's Office, Sherriff Jerry Clayton of the Washtenaw County Sherriff's Office, and the Washtenaw ID Task Force for their tireless commitment to developing and supporting the successful implementation of the Washtenaw ID. Additionally, we thank Vicenta Vargas and Skye Hillier for their contributions to the Washtenaw ID evaluation. We thank the Curtis Center for Research and Evaluation at the University of Michigan School of Social Work, the National Center for Institutional Diversity at the University of Michigan, and the University of California-Irvine Department of Chicano/Latino Studies and Program in Public Health for their support of the Washtenaw ID community-academic research partnership. Finally, we thank the reviewers for their helpful comments on earlier drafts of this manuscript. (Curtis Center for Research and Evaluation at the University of Michigan School of Social Work; National Center for Institutional Diversity at the University of Michigan; University of California-Irvine Department of Chicano/Latino Studies; Program in Public Health)https://link.springer.com/content/pdf/10.1007/s10903-017-0579-3.pdfPublished versio
Beewild' bundleflower, a new summer-growing perennial legume for central and south Texas and Mexico
Last updated: 10/19/201
Long non-coding RNA SNHG8 drives stress granule formation in tauopathies
Tauopathies are a heterogenous group of neurodegenerative disorders characterized by tau aggregation in the brain. In a subset of tauopathies, rare mutations in the MAPT gene, which encodes the tau protein, are sufficient to cause disease; however, the events downstream of MAPT mutations are poorly understood. Here, we investigate the role of long non-coding RNAs (lncRNAs), transcripts \u3e200 nucleotides with low/no coding potential that regulate transcription and translation, and their role in tauopathy. Using stem cell derived neurons from patients carrying a MAPT p.P301L, IVS10 + 16, or p.R406W mutation and CRISPR-corrected isogenic controls, we identified transcriptomic changes that occur as a function of the MAPT mutant allele. We identified 15 lncRNAs that were commonly differentially expressed across the three MAPT mutations. The commonly differentially expressed lncRNAs interact with RNA-binding proteins that regulate stress granule formation. Among these lncRNAs, SNHG8 was significantly reduced in a mouse model of tauopathy and in FTLD-tau, progressive supranuclear palsy, and Alzheimer\u27s disease brains. We show that SNHG8 interacts with tau and stress granule-associated RNA-binding protein TIA1. Overexpression of mutant tau in vitro is sufficient to reduce SNHG8 expression and induce stress granule formation. Rescuing SNHG8 expression leads to reduced stress granule formation and reduced TIA1 levels in immortalized cells and in MAPT mutant neurons, suggesting that dysregulation of this non-coding RNA is a causal factor driving stress granule formation via TIA1 in tauopathies
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A Comprehensive Resource for Induced Pluripotent Stem Cells from Patients with Primary Tauopathies.
Primary tauopathies are characterized neuropathologically by inclusions containing abnormal forms of the microtubule-associated protein tau (MAPT) and clinically by diverse neuropsychiatric, cognitive, and motor impairments. Autosomal dominant mutations in the MAPT gene cause heterogeneous forms of frontotemporal lobar degeneration with tauopathy (FTLD-Tau). Common and rare variants in the MAPT gene increase the risk for sporadic FTLD-Tau, including progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD). We generated a collection of fibroblasts from 140 MAPT mutation/risk variant carriers, PSP, CBD, and cognitively normal controls; 31 induced pluripotent stem cell (iPSC) lines from MAPT mutation carriers, non-carrier family members, and autopsy-confirmed PSP patients; 33 genome engineered iPSCs that were corrected or mutagenized; and forebrain neural progenitor cells (NPCs). Here, we present a resource of fibroblasts, iPSCs, and NPCs with comprehensive clinical histories that can be accessed by the scientific community for disease modeling and development of novel therapeutics for tauopathies
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