Prevalence of self-reported symptoms at the time of the survey by genotype.

<p>OR, odds ratio; aOR, adjusted OR; 95% CI, 95% confidence interval.</p><p>*Adjusted for age, sex, body mass index and current smoking habits.</p><p>Prevalence of self-reported symptoms at the time of the survey by genotype.</p

Prevalence of osteoarthritis, joint replacement, back pain and sciatica by genotype.

<p>* Adjusted for age, sex and body mass index.</p><p>Prevalence of osteoarthritis, joint replacement, back pain and sciatica by genotype.</p

Prevalence of osteoporosis and associated fractures by genotype

<p>* Adjusted for age, sex, body mass index, menopausal status and smoking habits</p><p>Prevalence of osteoporosis and associated fractures by genotype</p

Computed tomographic scans of the same knee showing osteoarthritis in the medial femoro-tibial compartment on a coronal reformation (A) and in the proximal tibio-fibular joint on a sagittal reformation (B).

<p>Osteoarthritic changes are consistent with multiple osteophytes (white arrows) and subchondral cysts (arrow heads). Articular calcifications are visible in the femoro-tibial compartment.</p

Mean score of cartilage lesion of the tibial plateaus in knees with/without meniscal calcifications, hyaline cartilage calcifications and CT-assessed osteoarthritis.

<p>Mean score of cartilage lesion of the tibial plateaus in knees with/without meniscal calcifications (MC+/MC<b>−</b>), hyaline cartilage calcifications (HCC+/HCC<b>−</b>) and CT-assessed osteoarthritis (CT-OA+/CT-OA<b>−</b>). The percentage of knees is calculated out of the 29 left knees analyzed after dissection and ink staining.</p

Detection of meniscal calcifications, hyaline cartilage calcifications and CT-assessed osteoarthritis in femoro-tibial and proximal tibio-fibular joints.

<p>Detection of meniscal calcifications, hyaline cartilage calcifications and CT-assessed osteoarthritis in femoro-tibial joints and proximal tibio-fibular joints expressed by subjects, knees and femoro-tibial compartments when applicable (<i>N/A</i>: not applicable). Osteoarthritis was considered for CT-assessed Kellgren and Lawrence (KL) grade ≥2.</p

Computed tomography scans of the same knee demonstrating calcifications within the hyaline cartilage (black arrows, arrow heads) and the meniscal segments (white arrows) in the femoro-tibial joint on a sagittal (A) and coronal (B–C) reformations, and in the proximal tibio-fibular joint on a sagittal reformation (D).

<p>Computed tomography scans of the same knee demonstrating calcifications within the hyaline cartilage (black arrows, arrow heads) and the meniscal segments (white arrows) in the femoro-tibial joint on a sagittal (A) and coronal (B–C) reformations, and in the proximal tibio-fibular joint on a sagittal reformation (D).</p

Distribution of calcifications in the hyaline cartilage of the femoral condyles.

<p>Each condyle was divided into inner, middle and outer thirds for analysis.</p

Correlation between CT-assessed osteoarthritis in femoro-tibial joints (OA⁺ FTJ) and proximal tibio-fibular joints (OA⁺ pTFJ).

<p>Correlation between meniscal calcifications (MC), hyaline cartilage calcifications in femoro-tibial joints (HCC FTJ) and hyaline cartilage calcifications in proximal tibio-fibular joints (HCC pTFJ). r = Spearman's correlation coefficient, p = value of Fisher's exact test.</p

Distribution of calcifications within the meniscal segments.

<p>Distribution of calcifications within the menisci. Each medial or lateral meniscus was divided into anterior, middle and posterior segments for analysis.</p