25 research outputs found
Studies of the renal component of the hypertension in rats with aortic constriction. Role of angiotensin II
Duplex–assisted internal carotid artery balloon angioplasty and stent placement: A novel approach to minimize or eliminate the use of contrast material
Carbon dioxide angiography for endovascular grafting in high-risk patients with infrarenal abdominal aortic aneurysms
Hibiscus sabdariffa extract lowers blood pressure and improves endothelial function
10.1002/mnfr.20130077
Ubiquitous transgenic overexpression of C-C Chemokine Ligand 2: A model to Assess the Combined Effect of High Energy Intake and Continous Low-Grade Inflammation
10.1155/2013/953841Excessive energy management leads to low-grade, chronic inflammation, which is a significant factor predicting noncommunicable diseases. In turn, inflammation, oxidation, and metabolism are associated with the course of these diseases; mitochondrial dysfunction seems to be at the crossroads of mutual relationships. The migration of immune cells during inflammation is governed by the interaction between chemokines and chemokine receptors. Chemokines, especially C-C-chemokine ligand 2 (CCL2), have a variety of additional functions that are involved in the maintenance of normal metabolism. It is our hypothesis that a ubiquitous and continuous secretion of CCL2 may represent an animal model of low-grade chronic inflammation that, in the presence of an energy surplus, could help to ascertain the afore-mentioned relationships and/or to search for specific therapeutic approaches. Here, we present preliminary data on a mouse model created by using targeted gene knock-in technology to integrate an additional copy of the CCl2 gene in the Gt(ROSA)26Sor locus of the mouse genome via homologous recombination in embryonic stem cells. Short-term dietary manipulations were assessed and the findings include metabolic disturbances, premature death, and the manipulation of macrophage plasticity and autophagy. These results raise a number of mechanistic questions for future study