Lytic bacteriophage is a promising adjunct to common antibiotics across cystic fibrosis clinical strains and culture models of Pseudomonas aeruginosa infection

Bacteriophages (phages) are antimicrobials with resurgent interest that are being investigated for the treatment of antibiotic refractory infection, including for Pseudomonas aeruginosa (Pa) lung infection in cystic fibrosis (CF). In vitro work supports the use of this therapy in planktonic and biofilm culture models; however, consistent data are lacking for efficacy across different clinical Pa strains, culture models, and in combination with antibiotics in clinical use. We first examined the efficacy of a 4-phage cocktail as an adjunct to our CF centre’s first-line systemic combination antibiotic therapy (ceftazidime + tobramycin) for 16 different clinical Pa strains and then determined subinhibitory interactions for a subset of these strains with each antibiotic in planktonic and biofilm culture. When a 4-phage cocktail (4 × 108 PFU/mL) was added to a ceftazidime-tobramycin combination (ceftazidime 16 mg/mL + tobramycin 8 mg/mL), we observed a 1.7-fold and 1.3-fold reduction in biofilm biomass and cell viability, respectively. The four most antibiotic resistant strains in biofilm were very susceptible to phage treatment. When subinhibitory concentrations of antibiotics and phages were investigated, we observed additivity/synergy as well as antagonism/inhibition of effect that varied across the clinical strains and culture model. In general, more additivity was seen with the phage-ceftazidime combination than with phage-tobramycin, particularly in biofilm culture, where no instances of additivity were seen when phages were combined with tobramycin. The fact that different bacterial strains were susceptible to phage treatment when compared to standard antibiotics is promising and these results may be relevant to ongoing clinical trials exploring the use of phages, in particular in the selection of subjects for clinical trials

White Screen/White Noise: Racism on the Internet

The Internet is critical for disseminating information, but it does not discriminate against information it carries. Hate speech and racist representations proliferate in social media, online news comment sections and community forums. What can information workers do to counteract those messages? How can critical race consciousness enhance on- and off-line library services? This article attempts to explore how information in the age of rapid technology innovation contributes to structural racism and what librarians and other information professionals can do about it

White Screen/White Noise: Racism and the Internet

The Internet is critical for disseminating information, but it does not discriminate against information it carries. Hate speech and racist representations proliferate in social media, online news comment sections and community forums. What can information workers do to counteract those messages? How can critical race consciousness enhance on- and off-line library services? This article attempts to explore how information in the age of rapid technology innovation contributes to structural racism and what librarians and other information professionals can do about it

Assessment of health sciences and science and technology librarian e-science educational needs to develop an e-science web portal for librarians

In the summer of 2009, the Lamar Soutter Library at the University of Massachusetts Medical School applied for and was awarded funding from the National Network of Libraries of Medicine, New England Region (NN/LM NER), to begin the construction of an e-science educational web portal specifically for librarians. The e-science web portal team\u27s first task was to assess the region\u27s health sciences and science and technology librarians and their e-science needs and learner preferences in order to help guide and inform the construction of the portal. The objectives of this assessment were threefold. The first was to establish that there was indeed a need for an e-science portal for librarians. The second was to examine what types of e-science and data services were being undertaken by these librarians and their libraries in New England. The third was to identify the background of the region\u27s health sciences and science and technology librarians as well as their educational needs and Web 2.0 tool preferences in order to develop the scope and transmission mechanism of online educational materials concerning e-science. Using feedback from librarian interviews from attendees of an e-science symposium and boot-camp, we researched and developed questions to survey learner needs. The results of the survey clearly show that a small, but significant number of New England libraries serving the health sciences are currently engaged in e-science activities within their institutions or with other institutions and that a larger group of health sciences and science and technology librarians see potential for e-science collaborations in the future. These results, from a sizeable representative sample of respondents, clearly establish that an e-science web portal specifically for librarians is both wanted and needed by New England\u27s library community. These results also show a regional demand for a portal centralizing e-science and data services tools and scientific content tutorials to serve patrons in basic as well as emerging information technology and data-intensive scientific disciplines. Moreover, the results present a community that is comfortable utilizing a variety of educational Web 2.0 tools for its self-guided learning and that is interested in future continuing education and professional development opportunities focusing on e-science

An Assessment of Needed Competencies to Promote the Data Curation and Management Librarianship of Health Sciences and Science and Technology Librarians in New England

Purpose: The purpose of this study was to evaluate health sciences and science and technology librarians’ needed data curation and management (DCM) competencies to support nascent and future patron and institutional eScience research endeavors. The data from this research will be used to align a data curation and management curriculum with the educational needs of an online eScience portal community of users, and create relevant future professional development for librarians interested in data curation and eScience librarianship. Setting/Participants: The study targeted the needed data curation and data management competencies of health sciences and science and technology librarians in six U.S. states who are on a listserv of librarians interested in learning about eScience. The sample for this study was 63 librarians. Methodology: The team created the assessment tool using content analyses of digital curation and management library literature and LIS data management curricula. The survey contained 15 open-ended and closed-ended questions and was distributed to 141 librarians using Survey- Monkey (http://www.surveymonkey.com). Results/Outcomes: The team identified twenty needed competency areas related to data curation and data management. The participants identified the necessary competencies to provide data curation and data management services. Results revealed a small number of librarians engaged in DCM and infrequent data services requests. Findings suggest there is an increase in libraries pursuing strategic plans concerning data management and the library community needs to cultivate a diverse range of technical and non-technical competencies through future professional development. Librarians saw their future roles involving DCM and sought competencies in conducting data interviews with patrons and helping patrons with NSF data management requirements. The survey results indicate the greatest need for librarians is technical hands-on training in the digital description and curation of large data sets. Discussion/Conclusion: Librarians are interested in developing data curation and data management competencies to support eScience. These data indicate that future relevant professional development for librarians interested in eScience should focus on non-technical and technical DCM competencies

Data Curation and Management Competencies of New England Region Health Sciences and Science and Technology Librarians

Objective: To identify specific data curation and management competencies that would aid in the continued development of a data management curriculum and professional development supporting New England health sciences and science and technology librarians, and to gather data on the nature and progress of data services being provided by these librarians and those being demanded by their patrons. Methodology: Based on a content analysis of data services and e-science librarian job postings, selected library and information science schools¹ programs and curricula, and published case studies and related best practices, the team researched and developed questions for the survey. An assessment was created using SurveyMonkey. A small group of medical librarians tested the survey and offered feedback. The survey was revised and then disseminated to New England health sciences and science and technology librarians. After three weeks, the team collected and analyzed the results. Results and Conclusion: A quarter of respondents surveyed stated that they are already managing and curating data sets. This number has nearly doubled since the team\u27s 2009 assessment of New England health sciences and science and technology librarians engaged in e-science. Almost half of respondents will be providing these services in the future; almost three quarters of respondents stated their library has or is in the process of creating a data management policy. Their responses to the competencies suggest that the portal curriculum focus on technical resources that would develop librarians¹ competencies in data literacy, curation and management by teaching skills such as scripting and programming languages and metadata and interoperability standards, as well as skills necessary to administer an institutional data repository. The data also suggest that a curriculum provide resources that address the non-technical competencies necessary to develop a data management policy, understand intellectual property and scholarly communication related to data. This research is helping the University of Massachusetts Medical School Lamar Soutter Library and National Network of National Libraries of Medicine New England Region (NN/LM NER) to develop its E-Science Portal data management curriculum and in-person professional development programming for its regional librarians engaged in e-science activities. In addition, this assessment illuminates the many challenges that health sciences libraries in New England are facing trying to engage in e-science. Thus, an area for future investigation is the strategies that libraries are using to deal with these challenges and overcome these obstacles

A Sample of Research Data Curation and Management Courses

Objective This paper identifies a sample of research data curation and management courses available at American Library Association-accredited Library and Information Science (LIS) Programs in North America. Methods This sample was identified through a content analysis of LIS program course descriptions and syllabi (N=58). Using a framework of research data management and curation competencies, the team gathered a sample of research data curation and management courses offered between fall 2011 and summer 2012. Results Only 13 (22%) of LIS programs currently offer a course focused on the management and curation of research data. Conclusion Although the literature supports LIS professionals adopting new roles and engaging in eScience and data management, most LIS data-related programs do not have a separate course solely focused on research data management. More LIS programs will need to adapt their curricula in order to help students and practicing professionals develop the needed competencies in research data curation and management

Bilateral Internuclear Ophthalmoplegia in a Patient with Devic's Neuromyelitis Optica

An unusual presentation of Devic's neuromyelitis optica (NMO) disease associated with bilateral internuclear ophthalmoplegia (INO) is described. A 32-year-old pregnant patient was diagnosed with NMO. First symptoms were headache and sudden visual loss in her right eye (RE). Eighteen months ago, she reported other neurologic symptoms such as paresthesia. Based on her visual field, fundoscopy and Ishihara test, she was diagnosed with retrobulbar neuritis of the RE. After delivery, new neurologic symptoms resembling transverse myelitis appeared. She was treated with methylprednisolone and plasmapheresis, which improved her visual acuity; however, a sudden bilateral INO appeared, with adduction defect and nystagmus with abduction in both eyes. No improvement was obtained after treatment with azathioprine and rituximab. Paresis of the legs and the right arm persisted, but double vision and OIN gradually disappeared. At the end, the patient had a residual exophoria in the RE and nystagmus with abduction in the left eye. Prevalence of NMO is lower than one case per one million inhabitants, and it is not likely to affect the encephalic trunk; furthermore, bilateral INO in NMO is rare. Two major criteria and at least two of the three minor ones are required to confirm a NMO diagnosis, and our patient fulfilled these diagnosis criteria

Fast selective harmonic mitigation in multifunctional inverters using internal model controllers and synchronous reference frames

This paper presents a fast selective harmonic current mitigation strategy for inverters with active power filter capabilities based in synchronous reference frames and twodegrees-of-freedom internal model controllers. The advantage of this control strategy over the conventional PI solution is a significant increase in the speed of harmonic detection and mitigation. Furthermore, this control strategy reduces the computational burden when applied in a digital controller. These characteristics make this strategy desirable for applications where fast/harmonic detection and mitigation are needed. Mathematical analysis and simulations are presented to corroborate the performance of the proposed controller strategy. Finally, the results of this proposal are verified in a 1kW 3-phase multifunctional inverter with harmonic compensation capabilities up to the 17th harmonic

Building an e-Science Portal for Librarians: A Model of Collaboration

The e-Science Portal for New England Librarians (http://esciencelibrary.umassmed.edu) is an openly accessible website targeted specifically for librarians working in research institutions that generate, share, store and/or use data for basic scientific research in the health, biological, and physical sciences. The portal provides links to information on e-Science, e-Science librarianship, current practices, and science disciplines. The portal’s e-Science Community blog http://esciencecommunity.umassmed.edu serves as a bulletin and discussion forum for the latest news, upcoming events, and commentaries. While the portal was originally developed to provide e-Science information to New England Librarians, its openly accessible content is relevant to librarians interested in networked science worldwide. Content for the e-Science Portal for New England Librarians is contributed by a team of nine content editors who are science and medical librarians from diverse New England research libraries. Each content editor identifies, annotates, and aggregates links to resources for a designated focus area of the portal and submits them to the portal’s project coordinator for further review. Following this review, the project coordinator and the portal development team plan the organization and layout of the content in the relevant subject web pages of the portal. The effective collaboration among the content editors and the portal design team has been crucial to the development of an e-Science Portal that provides the essential resources and tools needed by librarians engaging in networked science. The focus of this paper is the model of collaboration adopted by the portal’s design team and content editors