Correlations of body weight with cardiac function and myocardial wall thickness.

<p>LVPWd = diastolic left ventricular posterior wall diameter; IVSd = diastolic interventricular septal wall thickness; LIMP = left myocardial performance index; RVOT AccT = acceleration time of flow in the right ventricular outflow tract.</p

Correlations of body weight with pulmonary function.

<p>VC = vital capacity. FEV1 = forced expired volume at one second. MEF 25 = Mean expiratory flow 25. P 0.1 = mouth occlusion pressure at 0.1 second.</p

Anthropometric data.

<p>Data are shown as mean ± standard deviation.</p><p>Anthropometric data.</p

Baseline and follow-up data, absolute changes and p values.

<p>Data are shown as mean ± standard deviation. This table shows data of subjects with corresponding data at both timepoints, baseline and follow-up examination.</p><p>Baseline and follow-up data, absolute changes and p values.</p

Baseline data: Bodyplethysmography including mouth occlusion pressure and echocardiography.

<p>Data are shown as mean ± standard deviation.</p><p>Baseline data: Bodyplethysmography including mouth occlusion pressure and echocardiography.</p

Correlations of changes of pulmonary function with changes of body weight and changes of body fat and change of FEV1/VC from baseline to follow-up.

<p>a–c: Correlations of changes of pulmonary function with changes of body weight and changes of body fat (a–c) d: Change of FEV1/VC (%) ratio from baseline to follow-up (d), (data as mean ± SD), p = 0.006. VC = vital capacity. FEV1 = forced expired volume at one second.</p

Prevalence of comorbidities in relation to survival status (survivors: red bars, non-survivors: blue bars).

<p>The figure also denotes those comorbidities with a significantly (*) different prevalence in non-survivors compared with survivors regardless of their absolute prevalence.</p

Graphic expression (comorbidome) of comorbidities with more than 10% prevalence in the entire cohort, and those comorbidities with the strongest association with mortality (hazard ratio [HR] >1; 95% confidence interval >1; p<0.05).

<p>The area of the circle relates to the prevalence of the disease. The proximity to the centre (mortality) expresses the strength of the association between the disease and risk of death. This was scaled from the inverse of the HR (1/HR). All bubbles associated with a statistically significant increase in mortality are fully inside the dotted orbit (1/HR <1). Bubble colours represent organ systems or disease clusters (cardiovascular = red, pulmonary = green, others = orange).</p

Baseline characteristics of the patients in terms of pulmonary function, treatments, GAP stages, survival status, survival duration and death reasons.

<p>Baseline characteristics of the patients in terms of pulmonary function, treatments, GAP stages, survival status, survival duration and death reasons.</p

Impact of idiopathic pulmonary fibrosis and comorbidities on mortality.

<p>Hazard ratios (HR) have been determined using a predictive multivariate Cox proportional hazards regression model.</p