Additional file 1: Figure S1. of MiR-21 is required for efficient kidney regeneration in fish

Trichrome staining of kidney samples treated with antimiR-21 at different time points after gentamicin injection. As positive control old fibrotic fish kidney was used. Blue indicates fibrotic tissue, hematoxylin and eosin was used as counterstain. (PPTX 67880 kb

Additional file 2: Table S1. of MiR-21 is required for efficient kidney regeneration in fish

Clustered differentially expressed genes after treatment of N. furzeri with gentamicin, antimir-21 orgentamicin/antimir-21. (XLSX 429 kb

Image_1_Case report: Management of pediatric gigantism caused by the TADopathy, X-linked acrogigantism.pdf

X-linked acrogigantism (X-LAG) is a rare form of pituitary gigantism that is associated with growth hormone (GH) and prolactin-secreting pituitary adenomas/pituitary neuroendocrine tumors (PitNETs) that develop in infancy. It is caused by a duplication on chromosome Xq26.3 that leads to the misexpression of the gene GPR101, a constitutively active stimulator of pituitary GH and prolactin secretion. GPR101 normally exists within its own topologically associating domain (TAD) and is insulated from surrounding regulatory elements. X-LAG is a TADopathy in which the duplication disrupts a conserved TAD border, leading to a neo-TAD in which ectopic enhancers drive GPR101 over-expression, thus causing gigantism. Here we trace the full diagnostic and therapeutic pathway of a female patient with X-LAG from 4C-seq studies demonstrating the neo-TAD through medical and surgical interventions and detailed tumor histopathology. The complex nature of treating young children with X-LAG is illustrated, including the achievement of hormonal control using a combination of neurosurgery and adult doses of first-generation somatostatin analogs.</p