Parental age and ALL.

<p>Adjusted odds ratios for ALL comparing children with older mothers and fathers to children whose parents were aged less than 25 years. All odds ratios are adjusted for maternal and paternal age, respectively, and number of older siblings and socio-economic status. The analyses are based on 425 cases and 3′350 controls, aged 0–14 years. 11 cases (65 controls) were born to mothers younger than 20 years and 3 cases (21 controls) were born to fathers younger than 20 years. Figure footnote: y-axis is log-scaled.</p

Crude and adjusted odds ratios (OR) for ALL comparing children with older siblings to children without older sibling, stratified by age groups.

a<p>univariable conditional logistic regression model.</p>b<p>175 cases, 1382 controls.</p>c<p>130 cases, 1032 controls.</p>d<p>120 cases, 936 controls.</p>e<p>p values for trend were obtained including the variable continuously; the coding for number of older siblings was 0, 1, 2.</p>f<p>multivariable conditional logistic regression adjusted for maternal age, paternal age and socio-economic status.</p

Ft4 measures when TSH falls within the normal range.

<p>FT4 measures when TSH falls within the normal range (0.45–4.5 mU/L); 85% of abnormal fT4 measures are within 2 pmol/l (dashed lines) of the reference range (11.2 to 20.8 pmol/L, solid lines). Abbreviations: Free Thyroxine (fT4) Thyroid-Stimulating Hormone (TSH).</p

Participant characteristics.

<p>Participant characteristics.</p

Number of individuals with low, normal, and high TSH and FT4.

<p>Number of individuals with low, normal, and high TSH and FT4.</p