COPD association results in stage 1 and 2 for lung function sentinel variants analysed in stage 2.

<p>COPD association results in stage 1 and 2 for lung function sentinel variants analysed in stage 2.</p

Flow chart of the variant selection process.

<p>Flow chart of the variant selection process.</p

Collapsing methods results for most significant loci in stage 2.

<p>Collapsing methods results for most significant loci in stage 2.</p

Characteristics of Gedling and LRC individuals included in the study.

<p>Individuals with % predicted FEV₁<80% and FEV₁/FVC<0.7 (GOLD stage 2 cases) excluded from cases and controls. ^#Characteristics of cases and controls are shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0084192#pone-0084192-t002" target="_blank">Table 2</a>.</p

Characteristics of Gedling and replication COPD cases and controls.

<p>Characteristics of Gedling and replication COPD cases and controls.</p

Distributions of raw PRT copy number (top) and maximum likelihod integer copy number (bottom) for Gedling (right) and LRC (left) cohorts.

<p>Distributions of raw PRT copy number (top) and maximum likelihod integer copy number (bottom) for Gedling (right) and LRC (left) cohorts.</p

Sample selection for association analyses in Gedling and LRC.

<p>The sampling frame for each cohort is shown centrally with the COPD and asthma association analysis sample subsets indicated above and below for each cohort.</p

Association of DEFB with lung function, asthma and COPD in LRC and Gedling.

<p>P = 0.043 if maximum likelihood DEFB integer copy numbers used ^#controls for each analysis as defined in the method.</p

DEFB copy number in LRC asthma-ICS cases and controls.

<p>DEFB copy number in LRC asthma-ICS cases and controls.</p

Information of the 26 lung function-associated SNPs selected in the present study [13], [14], [15], [16].

<p>Columns 1 to 9 refer to frequencies, beta and p values for the association of SNPs with lung function fenotypes as found in the literature. Columns 10 to 15 refer to the frequencies and total sample sizes of the same or proxy-SNPs that were looked up in IMPROVE.</p><p>SNP ID: rs number for the SNPs selected from literature. Chr: chromosome, A1: coded allele, A1 freq: frequency of the coded allele, Measure reported: phenotype for which the SNP reached genome-wide significant association, SE: standard error, P: p-value for association with measure reported, proxy LD: linkage disequilibrium between SNP ID from literature (column 1) and the proxy used for replication in IMPROVE (column 11), proxy SNP: rs number for the proxy SNPs used for replication in IMPROVE, n: number of individuals tested in IMPROVE.</p