Fertility Decline and the Heights of Children in Britain, 1886-1938

In this paper we argue that the fertility decline that began around 1880 had substantial positive effects on the health of children, as the quality-quantity trade-off would suggest. We use microdata from a unique survey from 1930s Britain to analyze the relationship between the standardized heights of children and the number of children in the family. Our results suggest that heights are influenced positively by family income per capita and negatively by the number of children or the degree of crowding in the household. The evidence suggests that family size affected the health of children through its influence on both nutrition and disease. Applying our results to long-term trends, we find that rising household income and falling family size contributed significantly to improving child health between 1886 and 1938. Between 1906 and 1938 these variables account for nearly half of the increase in heights, and much of this effect is due to falling family size. We conclude that the fertility decline is a neglected source of the rapid improvement in health in the first half of the twentieth century.fertility decline, heights of children, health in Britain

The Effects on Stature of Poverty, Family Size and Birth Order: British Children in the 1930s

This paper examines effects of socio-economic conditions on the standardised heights and body mass index of children in Interwar Britain. It uses the Boyd Orr cohort, a survey of predominantly poor families taken in 1937-9, which provides a unique opportunity to explore the determinants of child health in the era before the welfare state. We examine the trade-off between the quality (in the form of health outcomes) and the number of children in the family at a time when genuine poverty still existed in Britain. Our results provide strong support both for negative birth order effects and negative family size effects on the heights of children. No such effects are found for the body mass index (BMI). We find that household income per capita positively influences the heights of children but, even after accounting for this, the number of children in the family still has a negative effect on height. This latter effect is closely associated with overcrowding and particularly with the degree of cleanliness or hygiene in the household, which conditions exposure to factors predisposing to disease. We also analyse evidence collected retrospectively, which indicates that the effects of childhood conditions on height persisted into adulthood.child health, heights, poverty

The Effects on Stature of Poverty, Family Size and Birth Order: British Children in the 1930s

This paper examines effects of socio-economic conditions on the standardised heights and body mass index of children in Interwar Britain. It uses the Boyd Orr cohort, a survey of predominantly poor families taken in 1937-9, which provides a unique opportunity to explore the determinants of child health in the era before the welfare state. We examine the trade-off between the quality (in the form of health outcomes) and the number of children in the family at a time when genuine poverty still existed in Britain. Our results provide strong support both for negative birth order effects and negative family size effects on the heights of children. No such effects are found for the body mass index (BMI). We find that household income per capita positively influences the heights of children but, even after accounting for this, the number of children in the family still has a negative effect on height. This latter effect is closely associated with overcrowding and particularly with the degree of cleanliness or hygiene in the household, which conditions exposure to factors predisposing to disease. We also analyse evidence collected retrospectively, which indicates that the effects of childhood conditions on height persisted into adulthood.child health, heights, poverty

Fertility Decline and the Heights of Children in Britain, 1886-1938

In this paper we argue that the fertility decline that began around 1880 had substantial positive effects on the health of children, as the quality-quantity trade-off would suggest. We use microdata from a unique survey from 1930s Britain to analyze the relationship between the standardized heights of children and the number of children in the family. Our results suggest that heights are influenced positively by family income per capita and negatively by the number of children or the degree of crowding in the household. The evidence suggests that family size affected the health of children through its influence on both nutrition and disease. Applying our results to long-term trends, we find that rising household income and falling family size contributed significantly to improving child health between 1886 and 1938. Between 1906 and 1938 these variables account for nearly half of the increase in heights, and much of this effect is due to falling family size. We conclude that the fertility decline is a neglected source of the rapid improvement in health in the first half of the twentieth century.fertility decline, heights of children, health in Britain

Accurate ab initio anharmonic force field and heat of formation for silane, SiH_4

From large basis set coupled cluster calculations and a minor empirical adjustment, an anharmonic force field for silane has been derived that is consistently of spectroscopic quality ($\pm 1 cm^{-1}$ on vibrational fundamentals) for all isotopomers of silane studied. Inner-shell polarization functions have an appreciable effect on computed properties and even on anharmonic corrections. From large basis set coupled cluster calculations and extrapolations to the infinite-basis set limit, we obtain TAE_0=303.80 \pm 0.18 kcal/mol, which includes an anharmonic zero-point energy (19.59 kcal/mol), inner-shell correlation (-0.36 kcal/mol), scalar relativistic corrections (-0.70 kcal/mol), and atomic spin-orbit corrections (-0.43 kcal/mol). In combination with the recently revised \HVSI{0}, we obtain $\Delta H^{\circ}_{f,0}[SiH_4(g)]=9.9 \pm 0.4 kcal/mol$, in between the two established experimental values.Comment: Mol. Phys., in pres

Preliminary design approach for large high precision segmented reflectors

A simplified preliminary design capability for erectable precision segmented reflectors is presented. This design capability permits a rapid assessment of a wide range of reflector parameters as well as new structural concepts and materials. The preliminary design approach was applied to a range of precision reflectors from 10 meters to 100 meters in diameter while considering standard design drivers. The design drivers considered were: weight, fundamental frequency, launch packaging volume, part count, and on-orbit assembly time. For the range of parameters considered, on-orbit assembly time was identified as the major design driver. A family of modular panels is introduced which can significantly reduce the number of reflector parts and the on-orbit assembly time

Improved Bounds for Drawing Trees on Fixed Points with L-shaped Edges

Let $T$ be an $n$-node tree of maximum degree 4, and let $P$ be a set of $n$ points in the plane with no two points on the same horizontal or vertical line. It is an open question whether $T$ always has a planar drawing on $P$ such that each edge is drawn as an orthogonal path with one bend (an "L-shaped" edge). By giving new methods for drawing trees, we improve the bounds on the size of the point set $P$ for which such drawings are possible to: $O(n^{1.55})$ for maximum degree 4 trees; $O(n^{1.22})$ for maximum degree 3 (binary) trees; and $O(n^{1.142})$ for perfect binary trees. Drawing ordered trees with L-shaped edges is harder---we give an example that cannot be done and a bound of $O(n \log n)$ points for L-shaped drawings of ordered caterpillars, which contrasts with the known linear bound for unordered caterpillars.Comment: Appears in the Proceedings of the 25th International Symposium on Graph Drawing and Network Visualization (GD 2017

Projections for future radiocarbon content in dissolved inorganic carbon in hardwater lakes: a retrospective approach

Inland water bodies contain significant amounts of carbon in the form of dissolved inorganic carbon (DIC) derived from a mixture of modern atmospheric and pre-aged sources, which needs to be considered in radiocarbon-based dating and natural isotope tracer studies. While reservoir effects in hardwater lakes are generally considered to be constant through time, a comparison of recent and historical DI14C data from 2013 and 1969 for Lake Constance reveals that this is not a valid assumption. We hypothesize that changes in atmospheric carbon contributions to lake water DIC have taken place due to anthropogenically forced eutrophication in the 20th century. A return to more oligotrophic conditions in the lake led to reoxygenation and enhanced terrigenous organic matter remineralization, contributing to lake water DIC. Such comparisons using DI14C measurements from different points in time enable nonlinear changes in lake water DIC source and signature to be disentangled from concurrent anthropogenically induced changes in atmospheric 14C. In the future, coeval changes in lake dynamics due to climate change are expected to further perturb these balances. Depending on the scenario, Lake Constance DI14C is projected to decrease from the 2013 measured value of 0.856 Fm to 0.54–0.62 Fm by the end of the century

Guadecitabine, in combination with Cyclophosphamide, promotes anti- cancer immunity in BALB/c mice bearing 4T1 mouse mammary carcinoma

Background: The extremely high mortality rate of patients diagnosed with triple negative breast cancer makes it one of the deadliest forms of cancer. Due to the heterogenous nature of tumors, complete clearance is not achieved and clonal selection occurs resulting in tumor cells evading the immune system. I aim to design a therapeutic intervention that is able to elicit an effective immune response against the tumor and instill immunological memory to eradicate primary and metastatic lesions. I hypothesize that the combination of Guad and Cyp will synergize and promote anticancer immunity via increased expression of neo-tumor antigens and depletion of MDSCs and T-regs. Methods: Guadecitabine (Guad), is a second-generation DNA methyltransferase inhibitor (DMNTi) that has been reported to increase antigenicity and deplete myeloid-derived suppressor cells (MDSC’s). Cyclophosphamide (Cyp) is a chemotherapy that has been shown to deplete regulatory T-cells (T-regs). Both MDSD’s and T-regs suppress antitumor immunity. BALB/c mice were challenged with 4T1 tumor cells subcutaneously in the mammary fat pad region. 4T1-bearing mice were administered low-dose Guad and Cyp for ten consecutive days. Tumor growth curves, tumor-infiltrating lymphocytes (TILs) were measured and MDSC’s and T- regs levels were assessed by flow cytometry. Results: Results from this experiment showed significant synergy between Guad and Cyp with both drugs reducing the tumor size over monotherapy. Conclusions: Further analysis of the data along with future experiments will elucidate if this synergy is driven by the depletion of MDSC’s and T-regs alone or the increase in tumor antigenicity inducing increased numbers of TILs.https://scholarscompass.vcu.edu/gradposters/1078/thumbnail.jp

When it Pays to Rush: Interpreting Morphogen Gradients Prior to Steady-State

During development, morphogen gradients precisely determine the position of gene expression boundaries despite the inevitable presence of fluctuations. Recent experiments suggest that some morphogen gradients may be interpreted prior to reaching steady-state. Theoretical work has predicted that such systems will be more robust to embryo-to-embryo fluctuations. By analysing two experimentally motivated models of morphogen gradient formation, we investigate the positional precision of gene expression boundaries determined by pre-steady-state morphogen gradients in the presence of embryo-to-embryo fluctuations, internal biochemical noise and variations in the timing of morphogen measurement. Morphogens that are direct transcription factors are found to be particularly sensitive to internal noise when interpreted prior to steady-state, disadvantaging early measurement, even in the presence of large embryo-to-embryo fluctuations. Morphogens interpreted by cell-surface receptors can be measured prior to steady-state without significant decrease in positional precision provided fluctuations in the timing of measurement are small. Applying our results to experiment, we predict that Bicoid, a transcription factor morphogen in Drosophila, is unlikely to be interpreted prior to reaching steady-state. We also predict that Activin in Xenopus and Nodal in zebrafish, morphogens interpreted by cell-surface receptors, can be decoded in pre-steady-state.Comment: 18 pages, 3 figure