Shared genetic factors underlie migraine and depression

Free to read\ud \ud Migraine frequently co-occurs with depression. Using a large sample of Australian twin pairs, we aimed to characterize the extent to which shared genetic factors underlie these two disorders. Migraine was classified using three diagnostic measures, including self-reported migraine, the ID migraine screening tool, or migraine without aura (MO) and migraine with aura (MA) based on International Headache Society (IHS) diagnostic criteria. Major depressive disorder (MDD) and minor depressive disorder (MiDD) were classified using the Diagnostic and Statistical Manual of Mental Disorders (DSM) criteria. Univariate and bivariate twin models, with and without sex-limitation, were constructed to estimate the univariate and bivariate variance components and genetic correlation for migraine and depression. The univariate heritability of broad migraine (self-reported, ID migraine, or IHS MO/MA) and broad depression (MiDD or MDD) was estimated at 56% (95% confidence interval [CI]: 53-60%) and 42% (95% CI: 37-46%), respectively. A significant additive genetic correlation (r G = 0.36, 95% CI: 0.29-0.43) and bivariate heritability (h 2 = 5.5%, 95% CI: 3.6-7.8%) was observed between broad migraine and depression using the bivariate Cholesky model. Notably, both the bivariate h 2 (13.3%, 95% CI: 7.0-24.5%) and r G (0.51, 95% CI: 0.37-0.69) estimates significantly increased when analyzing the more narrow clinically accepted diagnoses of IHS MO/MA and MDD. Our results indicate that for both broad and narrow definitions, the observed comorbidity between migraine and depression can be explained almost entirely by shared underlying genetically determined disease mechanisms

Familial aggregation of migraine and depression: Insights from a large Australian twin sample

Free to read\ud \ud Objectives: This research examined the familial aggregation of migraine, depression, and their co-occurrence.\ud \ud Methods: Diagnoses of migraine and depression were determined in a sample of 5,319 Australian twins. Migraine was diagnosed by either self-report, the ID migraine™ Screener, or International Headache Society (IHS) criteria. Depression was defined by fulfilling either major depressive disorder (MDD) or minor depressive disorder (MiDD) based on the Diagnostic and Statistical Manual of Mental Disorders (DSM) criteria. The relative risks (RR) for migraine and depression were estimated in co-twins of twin probands reporting migraine or depression to evaluate their familial aggregation and co-occurrence.\ud \ud Results: An increased RR of both migraine and depression in co-twins of probands with the same trait was observed, with significantly higher estimates within monozygotic (MZ) twin pairs compared to dizygotic (DZ) twin pairs. For cross-trait analysis, the RR for migraine in co-twins of probands reporting depression was 1.36 (95% CI: 1.24–1.48) in MZ pairs and 1.04 (95% CI: 0.95–1.14) in DZ pairs; and the RR for depression in co-twins of probands reporting migraine was 1.26 (95% CI: 1.14–1.38) in MZ pairs and 1.02 (95% CI: 0.94–1.11) in DZ pairs. The RR for strict IHS migraine in co-twins of probands reporting MDD was 2.23 (95% CI: 1.81–2.75) in MZ pairs and 1.55 (95% CI: 1.34–1.79) in DZ pairs; and the RR for MDD in co-twins of probands reporting IHS migraine was 1.35 (95% CI: 1.13–1.62) in MZ pairs and 1.06 (95% CI: 0.93–1.22) in DZ pairs.\ud \ud Conclusions: We observed significant evidence for a genetic contribution to familial aggregation of migraine and depression. Our findings suggest a bi-directional association between migraine and depression, with an increased risk for depression in relatives of probands reporting migraine, and vice versa. However, the observed risk for migraine in relatives of probands reporting depression was considerably higher than the reverse. These results add further support to previous studies suggesting that patients with comorbid migraine and depression are genetically more similar to patients with only depression than patients with only migraine

Etiological Histories of 35 Deaf and Hard-of-Hearing Residential School Students with Delinquent Behavior

This paper reviews the etiological histories of deaf and hard-of-hearing juveniles with delinquent behaviors. The etiologies of hearing loss and incidence of secondary or multiple disabilities in students with delinquent behaviors is examined through a review of existing school records for thirty- five (35) students born between the years of 1939-1986. Case studies, percentages, IQ scores, and reading grade level scores are used to provide a description of the neurological and behavioral issues of deaf and hard-of- hearing residential school youth who have experienced criminal legal problems. The purpose is to improve awareness among educators and juvenile Justice professionals of some potential effects of multiple disabilities on delinquency in signing deaf and hard of-hearing youth

Rivers of the Anthropocene, Phase 1: A Comparative Study of the Ohio and Tyne River Systems

poster abstractRivers of the Anthropocene” addresses a fundamental problem facing scholars and policy makers alike: despite important advances in our understanding of the earth as a system — one in which humans and human systems have become recognized as prime agents in effecting changes to the earth — we have yet to create an approach that brings together scholars of earth systems with scholars of human systems. This is to the detriment of our overall understanding of global ecological change and limits our ability to respond to escalating crises. Without integrating methods from the earth sciences, social sciences, and humanities, scholars of the environment lose important tools in tackling some of the biggest issues facing humanity in the 21st century. As humans continue to play an increasingly significant role in altering their planet, it is incumbent upon environmental scholars to understand the human-environment interface in all its complexities. It is not enough that scientists measure what humans have done or what they can do to shift environmental systems; it is necessary that they work hand-in-hand with specialists in human systems to understand the limits and feedback mechanisms that beliefs, practices, ideologies, social structures, and cultural norms impose on human action. A comparative study of international river systems is a good place to begin building more meaningful bridges across the science-humanities divide, and it addresses the pressing issue of global water insecurity, which 80% of the earth’s population faces. The first stage of “Rivers of the Anthropocene” will create a flexible, interdisciplinary methodological and conceptual framework for examining the human-environment interface, one in which specialists in the earth sciences can learn from the approaches of the humanities and human sciences and vice versa

The Influence of Trust and Attitudes on the Purchase Frequency of Organic Produce

Growth in organic food sales is mainly due to consumers becoming more aware of health issues and environmental concerns. Understanding the drivers of organic consumption is crucial to predict future market outcomes. In this analysis, the authors expand previous research by including general and institutional trust variables in addition to consumer attitudes to examine organic food purchases. Food production is unobservable and hence, consumers need to exhibit trust with respect to organic production and certification. A bivariate ordered probit model applied to U.S. survey data confirms that organic purchases are determined by health, nutrition, and taste. In some cases, general trust and trust in media are statistically significant. Trust in institutions that are involved in the organic certification process is not statistically significant. A hierarchical cluster analysis grouping consumers based on trust and attitudes shows that (dis)trust in the organic certification and supply chain does not hinder organic food market growth

Curriculum Materials for Elementary Reading: Shackles and Scaffolds for Four Beginning Teachers

The purpose of this longitudinal study was to learn how beginning elementary teachers understood and used curriculum materials for teaching reading, and how, in turn, these materials shaped teachers\u27 instruction. We followed 4 teachers who worked in markedly different school situations and were provided a variety of curriculum materials, ranging from scripted reading programs to supplemental materials without teaching guides. Data were gathered through classroom observations, interviews, and curriculum artifacts over the teachers\u27 first 3 years on the job. Our analysis suggested that curriculum materials interacted with teachers\u27 knowledge of reading and reading instruction, and with the contexts in which they worked. As a result, curriculum materials both fostered and inhibited teachers\u27 on-the-job learning. We found that the 2 teachers with weak knowledge or more restrictive materials and environments learned the least and were least able to adapt instruction to meet the needs of their students. The 2 teachers with stronger knowledge, access to multiple materials, and support for decision making regarding materials and instructional strategies learned the most and were most able to adapt instruction. Furthermore, early experiences with specific curriculum materials had effects 2 years later on these teachers\u27 instructional practices. Implications for curriculum mandates, material selection, and professional development are discussed